Research works

Clinical infection and molecular characteristics of carbapenem-resistant organisms among children in China, 2016-2025

Carbapenem-resistant organisms (CROs) pose a severe health threat to pediatric patients. We aimed to investigate the epidemiology, clinical infection, and molecular profiles of CROs in Chinese children from 2016 to 2025. We retrospectively analyzed 3655 non-duplicate CRO strains...

Pseudomonas aeruginosa-derived volatile organic compounds modulate AhR signaling to dysregulate airway mucus homeostasis

Pseudomonas aeruginosa frequently infects chronically diseased lungs and exacerbates airway mucus hypersecretion and failure in clearance. P. aeruginosa is metabolically versatile and secretes multiple volatile organic compounds (VOCs), which have been scrutinized as potential bi...

Emergency obstetric referrals in public primary health care centres in Benin City, Nigeria: a qualitative study

The aim of this study was to assess the mechanisms, procedures, and processes of the referral system for emergency obstetric care (EmOC) in public primary health care centres (PHCs) in Benin City, Edo State, Nigeria, with recommendations offered to address the challenges. A quali...

Advanced lung cancer inflammation index predicts in-hospital mortality and refines risk stratification in patients with cirrhosis

Conventional prognostic scores for liver cirrhosis frequently overlook the nutritional and systemic inflammatory status of patients. The Advanced Lung Cancer Inflammation Index (ALI) is a novel biomarker that integrates these two dimensions. This study aimed to investigate the cl...

Exploring socio-demographic factors associated with school attendance in Somaliland: A multilevel analysis

Despite persistent educational challenges in Somaliland, nationally representative evidence on factors associated with school attendance remains limited. Regular school attendance is a cornerstone of Sustainable Development Goal 4, which seeks to ensure inclusive and equitable qu...

Geometry-guided 3D Gaussian Splatting

This study proposes a novel 3D Gaussian splatting framework that maximizes the stability of scene reconstruction by integrating metric depth priors from UniDepthV2. While recent Gaussian Splatting-based techniques like self-supervised pose-free 3D Gaussian splatting (SPFSplat) ha...

Integrated inference of cellular compositions and gene expression programs by deconvolution

While computational deconvolution is routinely used to estimate cell-type proportions from tissue mixtures, reconstructing cell-type-specific transcriptomes at single-sample resolution remains a fundamentally underdetermined algorithmic challenge. Consequently, accurate single-sa...

A Study on LLM-based Method for deriving Critical Safety Items to Enhance Submarine Operational Safety

Submarines pose a high risk of catastrophic incidents that may result in significant loss of life and severe degradation of strategic capabilities. In this context, the systematic management of Critical Safety Items (CSIs) is a fundamental requirement throughout the design, const...

Molecular Flux Density Distribution at the Pump Flange of a Test Dome for Measuring the Speed of a High Vacuum Pump

A numerical analysis has been obtained on the distribution of the molecular flux density qo(r) at the pump aperture of a test dome for measuring the speed of a high vacuum pump. The caluculation was carried out based on solving Clausing's integral equation by using iterative appr...

Trauma burden, coping patterns, and psychological symptoms in Ahiska Turkish children and adolescents displaced following the Ukraine war: a cross-sectional study

War-related displacement may affect youth mental health through direct trauma exposure, family-level trauma burden, and coping processes. Ahiska Turkish families displaced after the Ukraine war are a historically important group because recent displacement may occur against a bac...

Research on intelligent content generation and adaptive presentation in virtual simulation scenarios

Virtual simulation technologies have become indispensable in education, medical training, psychological therapy, and industrial applications. However, traditional virtual systems rely heavily on static pre-designed content and simple rule-based adaptations, resulting in limited p...

School-based sexual violence prevention: A systematic review

Purpose Sexual violence profoundly affects the health and development of children, adolescents, and young adults, representing a persistent challenge to public policy. This systematic review examined the effectiveness of school-based interventions aimed at prevention. Methods Eig...

Dynamic Capabilities May Not Be Efficient: A Multiyear Econometric Analysis of Multiple Performance Dimensions Shows the Robust Absence of Systematic Relationships

Although dynamic capabilities (DCs) theoretically constitute the evolution of a firm’s capabilities, the research tends to examine this phenomenon from a static perspective. This paper presents a methodology for capturing dynamic capabilities to understand their longitudinal effe...

Inborn Errors of Immunity Genotype: A Retrospective Study from the United Arab Emirates

Inborn errors of immunity (IEI) contribute substantially to morbidity in the Middle East and North Africa (MENA), particularly in the United Arab Emirates (UAE), where high consanguinity increases the prevalence of autosomal-recessive and complex genetic disorders. Regional IEI g...

Prolonged indolent clinical course in a high-risk chronic phase-CML patient without cytogenetic or molecular response: a case challenging established response paradigms

Chronic-phase chronic myeloid leukemia (CP-CML) is currently treated with tyrosine kinase inhibitors (TKIs), and the early achievement of cytogenetic and molecular milestones is strongly associated with improved clinical outcomes. Here, we describe the case of a 55-year-old woman...

Residual Neural FIR Filtering for Robust State Estimation

Finite impulse response (FIR) filters are inherently robust owing to their finite-memory structure and independence from initial state statistics. However, they often lack the adaptivity required for time-varying environments. While recent neural-network-based FIR approaches addr...

Postural risk factors for work-related musculoskeletal disorders during manual versus device-assisted lower-limb stretching

Work-related musculoskeletal disorders (WMSDs) are prevalent among physiotherapists and occupational therapists due to the physically demanding and repetitive nature of manual therapy techniques. Stretching requires therapists to exert substantial force while holding static postu...

A CNN-based Unsupervised Learning System for Detecting Stator Pin Insertion Defects in Blower Motors for Industrial Environments

This study proposes a system for detecting defective automobile blower motors based on deep one-class classification (DOCC). DOCC determines defects by learning only normal data to overcome the limited data environment experienced in the actual industrial sites where it is diffic...

Exploring the role of place visitation big data on small area health measure estimation

Population-level health measures at small geographic scales (e.g., census tracts), including health conditions, preventive behaviors, risk factors, and overall health status, are crucial for guiding effective health planning and policymaking. It has been well established that dem...

Two Cases of Type 2 Thyroplasty Performed during Pregnancy (First to Second Trimester)

痙攣性発声障害（spasmodic dysphonia：SD）に対する甲状軟骨形成術2型（type 2 thyroplasty：TP2）は有効性が確立された手術であるが，妊娠中の施行に関する報告はない。今回我々は，音声障害により日常生活・業務に支障をきたした2例の妊婦に対し，局所麻酔下TP2を妊娠初期～中期に実施し，良好な母...