Research works

Celestial amplitudes on electromagnetic backgrounds: T-duality from S-duality

Abstract What is the boundary holographic dual of S-duality for gauge theories in asymptotically flat space-times? Celestial amplitudes, by virtue of exhibiting holographic properties of the S-matrix, appear well-suited for studying this question. We scatter electrically and magn...

Automated optimization of force field parameters against ensemble-averaged measurements with Bayesian inference of conformational populations

Accurate force fields are essential for reliable molecular simulations. These models are refined against quantum mechanical calculations and experimental measurements, which are subject to random and systematic errors. Bayesian Inference of Conformational Populations (BICePs) is...

Urbanization and electoral success: lawyers and workers in interwar France

This study argues that urbanization altered the relationship between candidates’ occupation and their electoral success. To identify the causal effect of local variation in urbanization, we exploit exogenous changes in the boundaries of electoral constituencies in the 1928, 1932,...

ValuesML: A new multilingual dataset for values detection in news and political manifestos

Abstract Values are important building blocks of political ideologies and are frequently invoked in political debates. Yet, because values are abstract, understanding how they are expressed in real-world discourse, and how this varies across contexts, remains a challenge. In this...

Bayesian model discovery for reverse-engineering biochemical networks from data

Abstract The reverse engineering of gene regulatory networks based on gene expression data is a challenging inference task. A related problem in computational systems biology lies in identifying signalling networks that perform particular functions, such as adaptation. Indeed, fo...

Improved specificity of a probe-based real-time PCR for the detection of Dirofilaria immitis in canine blood

Abstract Background Dirofilaria immitis is a vector-borne filarioid nematode distributed worldwide and endemic across most of North America. In dogs, it is considered the most important parasite and a known cause of acquired cardiomyopathy. Clinically, canine heartworm disease ca...

PPARG directs trophoblast cell fate and establishment of the uterine-placental interface

Abstract The expansion and differentiation of trophoblast stem (TS) cells are critical for defining fundamental properties of the placenta. Specialized trophoblast cells called extravillous trophoblast (EVT) cells in human and invasive trophoblast cells in rat, exit the placenta,...

A simple demonstration of a privacy-preserving de-centralised genotype imputation workflow

Abstract Recently, a number of studies have looked at the problem of privacy and data-sharing restrictions in the context of missing genotype imputation servers. This relates to the most typical imputation pipelines which involve a whole-genome sequenced haplotype reference panel...

Data and context matter: towards generalizing AI-based software vulnerability detection

AI-based solutions demonstrate remarkable results in identifying vulnerabilities in software, but research has consistently found that this performance does not generalize to unseen codebases. In this paper, we specifically investigate the impact of model architecture, parameter...

MARLOWE: taxonomic characterization of unknown samples for forensics using de novo peptide identification

Abstract We present a computational tool, MARLOWE, for source organism characterization of unknown, forensic biological samples. The intent of MARLOWE is to address a gap in applying proteomics data analysis to forensic applications. MARLOWE produces a list of potential source or...

Accelerating protein design by scaling experimental characterization

Abstract Recent advances in de novo protein design have greatly outpaced standard protein biochemistry workflows, and experimental testing has been a bottleneck in the validation of new designs and methodologies. Here, we describe experimental and computational workflows to addre...

NEXUS Personalized Health, One platform to make your biomedical research possible

We are NEXUS Personalized Health at the ETH Zurich. Our friends call us NEXUS. We offer highly customizable services and collaborations in the field of biomedical research and development. A pool of professional scientists in bioinformatics, data science, statistics, software eng...

NEXUS Personalized Health, One platform to make your biomedical research possible

We are NEXUS Personalized Health at the ETH Zurich. Our friends call us NEXUS. We offer highly customizable services and collaborations in the field of biomedical research and development. A pool of professional scientists in bioinformatics, data science, statistics, software eng...

Tetrahydrocurcumin ameliorates depression-like behaviors in chronic restraint stress mice by modulating neuroinflammation and neurotrophic balance via the SIRT1/NF-κB pathway.

OBJECTIVES: the SIRT1/NF‑κB pathway. METHODS: experiment, BV2 microglial cells were stimulated with lipopolysaccharide (LPS) and treated with THC with or without the SIRT1 inhibitor EX-527 for validating the pathway mediating the effect of THC. RESULTS: cells and increased SIRT1...

SPN 313: Advanced Communication Skills

This syllabus for SPN 313 (Advanced Communication Skills) at the College of Staten Island, CUNY, presents a zero-textbook-cost, OER-based course in advanced academic writing in Spanish designed for a mixed population of heritage speakers and advanced second-language learners. The...

The Missing Link in ERP Customization

Enterprise Resource Planning (ERP) systems provide organizational stability but often lack the flexibility needed for specific process adaptations. While Low-Code platforms (LCP) enable domain experts to design extensions, the integration of business process libraries (BPLs) with...

The Physicality of Scales: An Emergent Hierarchy from Minimal Axioms in Quantum-Geometry Dynamics

This paper proposes physically grounded definitions of object and scale within the framework of Quantum-Geometry Dynamics (QGD) and the Minimal Physically Derivable Theories (MPDT) programme established by the Uniqueness Theorem. Both definitions have been absent from the existin...

Human Resource Management Reform in Fragile State Bureaucracies: Challenges and Opportunities in the 2020s

This article examines Human Resource Management Reform in Fragile State Bureaucracies: Challenges and Opportunities in the 2020s with a focused emphasis on Uganda within the field of Law. It is structured as a conference paper that organises the problem, the strongest verified sc...

Human Resource Management Reform in Fragile State Bureaucracies: Challenges and Opportunities in the 2020s

This article examines Human Resource Management Reform in Fragile State Bureaucracies: Challenges and Opportunities in the 2020s with a focused emphasis on Uganda within the field of Law. It is structured as a conference paper that organises the problem, the strongest verified sc...

A Theoretical Framework for Sustainable Enterprise Governance in the Cape Verdean Archipelago, 2020–2026

The unique archipelagic context of Cape Verde presents distinct challenges and opportunities for sustainable enterprise governance, which remain under-theorised in the African behavioural finance literature. Existing frameworks often fail to account for the interplay between smal...