Research works

Effects of Plant Polyphenols on Obesity-Induced Inflammatory Depression: A Review

Epidemiological and clinical evidence indicates that obesity-associated metabolic dysfunction increases the risk of depression, which is often resistant to conventional antidepressant therapies. Elucidating targeted mechanisms underlying obesity-related depression is therefore es...

CoxFormer enables spatial omics inference with multimodal generative modeling

Gene co-expression maps transcriptome-wide gene-gene relationships, yet high-quality estimates cover less than half the genome. Meanwhile, spatial omics either profiles restricted in situ panels or lacks cellular resolution. Extending co-expression transcriptome-wide could overco...

Factors Associated with Documented Arrhythmia Recurrence After Cryoballoon Ablation in a Low-Risk Atrial Fibrillation Population Without Major Comorbidities

Background: Arrhythmia recurrence after cryoballoon ablation remains a clinically relevant problem in atrial fibrillation (AF). However, factors associated with documented recurrence in low-risk patients without major comorbidities are not well defined. This study aimed to evalua...

The CCHCR1–UBAP2L Interaction Promotes UBAP2L Release from P-Bodies for Stress Granule Assembly

Ribonucleoprotein granules such as processing bodies (P-bodies) and stress granules (SGs) are membrane-less organelles that regulate mRNA metabolism through liquid–liquid phase separation. UBAP2L drives SG assembly and can bridge P-bodies with SGs, yet how it is mobilized between...

Porphyrin-based molecular wires: From polaron delocalization to phase-coherent single-molecule transport — a Woodward Career Award paper

Molecular wires are the most fundamental type of single-molecule electronic device and they are the components of organic semiconductors. Porphyrins are excellent building blocks for constructing molecular wires because their small reorganization energies and rich redox activity...

Quantitative method for evaluating nonstandard tissue absorption characteristics using synergetic near-infrared laser thermography and analytical modeling tools

Abstract The field of laser therapeutic and diagnostic devices has a growing need for innovative experimental and analytical tools to support development of standardized methods for evaluating laser safety and performance. Current laser exposure limits in recognized standards app...

Fitting Accumulated Stock Returns with Tempered Skew t-Distribution

We analyze the distributions of historic S&P500 multi-day returns for the number of days of accumulation from 20 to 120. With the increase in the number of days of accumulation, we observe clear tempering of power-law tails toward a seemingly finite value. To explain this phenome...

The endothelial PECAM1–CXCR4 axis amplifies neutrophil degranulation to exacerbate sleep-deprived periodontitis: a systems-level framework for comorbidity therapy

Sleep deprivation (SD) is a known risk factor for periodontitis (PD), but the molecular bridge connecting this systemic stressor to local inflammation remains elusive. Here, through a systems-level investigation integrating human epidemiology, multi-omics, and disease modeling, w...

Investigating spatial thinking-based puzzle tasks for improving geometric reasoning.

While there is support for the success of spatial training on both spatial ability and mathematics outcomes (Hawes et al., 2022; Uttal et. al., 2013), it is unclear whether spatial training is effective for increasing success on verbal mathematical reasoning tasks or has impacts...

Hypoxia-activated scleraxis a mediates epicardial progenitor differentiation into a unique cardiac perivascular cell type

Abstract The epicardium is a crucial source of progenitor cells and paracrine signals that support heart development and regeneration. However, the molecular mechanisms that guide epicardial cell fate decisions remain incompletely understood. Here, we identify the transcription f...

Reimagining public governance through the commons: prefigurative legality at play?

Abstract This article contributes to the emerging scholarship on prefigurative legality by prompting critical questions on the boundaries of prefigurative legality itself. The article does so by reviewing two selected experiments for creating urban commons in Italy. Both experime...

ConvRML: high-quality lensless imaging with random multi-focal lenslets

Initial public release associated with the accompanying manuscript.

Measurement Report: Quantitative analysis of aerosol acidity and its driving factors in Guanzhong area, Northwest China

Abstract. Aerosol acidity significantly affects atmospheric chemistry and human health, yet its driving factors remain controversial. This study systematically examined a year-long characteristics of water-soluble inorganic ions in PM2.5 in the semi-arid Guanzhong Plain, Northwes...

The impact of authorship and AI attitude on the perception of message credibility and author competence

Generative artificial intelligence (AI) is increasingly changing the way information is conveyed which raises questions about the perception of author competence and message credibility. This study examines the extent to which the type of author (human vs. AI) and the gender of t...

The profinite rigidity of torsion-free lamplighter groups

Abstract We prove that the torsion-free lamplighter group $$\Gamma = \mathbb {Z}^n \wr \mathbb {Z}$$ Γ = Z n ≀ Z of any rank $$n \in \mathbb {N}$$ n ∈ N is profinitely rigid in the absolute sense: the finite quotients of $$\Gamma $$ Γ determine its isomorphism type uniquely among...

The Shortest Path to Zionism: A Network Analysis of the US Nonprofit Industrial Complex

Activists have shown how the nonprofit industrial complex (NPIC) co-opts grassroots social movements, and how the dependence on donors limits what nonprofits can say or do—especially concerning Palestine. Yet the NPIC is rarely analyzed as a whole system. This article analyzes th...

Using LIDAR and SNOTEL data for evaluating the performance of snow water equivalent retrieval using Sentinel-1 repeat-pass interferometry

Abstract. Accurate estimation of snow water equivalent (SWE) at high spatial and temporal resolution remains a critical challenge for hydrologic prediction and climate monitoring. Interferometric Synthetic Aperture Radar (InSAR) provides a promising approach for retrieving SWE by...

AutoEDA: Enabling EDA Flow Automation through Microservice-Based LLM Agents

Electronic Design Automation (EDA) remains heavily reliant on tool command language (Tcl) scripting to drive complex RTL-to-GDSII flows. This scripting-based paradigm is labor-intensive, error-prone, and difficult to scale across large design projects. Recent advances in large la...

Boundaries of Multiply Connected Fatou Components: A Unified Approach

Abstract We analyze the boundaries of multiply connected Fatou components of both rational and transcendental maps by means of universal covering maps and associated inner functions. A unified approach is presented, which includes invariant Fatou components (of any type) as well...

Histopathology and spatial transcriptomics jointly map myofiber-specific pathological programs in mTORC1-driven myopathy

Skeletal muscle is a structurally organized and functionally diverse organ composed of heterogeneous myofiber types and supporting non-myocyte populations that act in concert to generate force, regulate metabolism, and maintain systemic homeostasis. Myopathies occur in many diffe...