Research works

Data-driven safety certificates of infinite networks with unknown models and interconnection topologies

Infinite networks are complex interconnected systems comprising a countably infinite number of subsystems, for which no fixed upper bound on the number of participating subsystems is specified a priori since it may vary over time as agents join or leave (e.g., vehicles in traffic...

Reversible Switching due to Attraction and Repulsion: Clusters, Gaps, Sorting, and Mixing

Abstract. We describe a phase transition in continuum limits of interacting particle systems that exhibits a vertical bifurcation diagram. The transition is mediated by a competition short-range repulsion and long-range attraction. As a consequence of the transition, infinitesima...

A Rockafellar Theorem for cyclically quasi-monotone maps: the regular non-vanishing case

We study the connection between cyclic quasi-monotonicity and quasi-convexity, focusing on whether every cyclically quasi-monotone (possibly multi-valued) map is included in the normal cone operator of a quasi-convex function, in analogy with Rockafellar's theorem for convex func...

Two Sample Testing for High-dimensional Functional Data: A Multi-Resolution Projection Method

It is of great interest to test the equality of the means in two samples of functional data.Past research has predominantly concentrated on lowdimensional functional data, a focus that may not hold in high-dimensional scenarios.In this article, we propose a novel two-sample test...

Tmem117, an oligodendrocyte-enriched regulator of NCX activity, links myelin homeostasis to counterregulation and metabolic health

Abstract The counterregulatory response (CRR) to hypoglycemia is a fundamental, evolutionarily conserved homeostatic mechanism orchestrated by the central nervous system (CNS) to ensure survival during glucose scarcity. In individuals with diabetes, this response is frequently im...

The DLX/Notch axis is necessary for spatiotemporal regulation of neural cell fate

Neuronal-glial cell fate switch during forebrain development is highly regulated. DLX transcription factors are necessary for promoting GABAergic interneuron differentiation and migration but the mechanisms for concomitant repression of glial fate in neural progenitors remain elu...

Lateral internal sphincterotomy with skin grafting for chronic anal fissure: protocol of a multi-center randomized controlled trial

Abstract Background: Anal fissure, a prevalent anorectal disorder, is defined as a longitudinal tear in the anoderm distal to the dentate line.Chronicity develops in a substantial fraction of anal fissures despite initial conservative success, resulting in significant quality-of-...

Both CD8+ and CD4+ T regulatory cells are associated with poor survival in colorectal cancer

Abstract Previous studies in colorectal cancer have linked high levels of FoxP3 + regulatory T-cells (Treg) (CRC) to favourable prognosis. However, this contradicts the well-established immunosuppressive function of Treg. We resolved this conundrum using multiplex immunohistochem...

Viral commitment to infection depends on host metabolism

Viral infection begins with attachment to host surface structures such as receptors, pili, or porins. While prior research has focused on structural compatibility and recognition, the role of host physiology, particularly metabolic state, on viral commitment to infection remains...

To profit or not to profit? Evidence from Chile’s for-profit voucher schools

This note examines whether for-profit management affects educational outcomes in Chile’s voucher system. Using administrative panel data for all voucher-subsidised primary schools from 2010 to 2014, we compare for-profit and nonprofit schools in terms of inputs and student perfor...

Insights into the development and key factors of five European governance innovations for forest ecosystem service provision

Climate change and biodiversity loss necessitate the forestry sector to adapt its management practices to provide forest ecosystem services (FES) sustainably. However, there is a limited understanding of influences that foster novel governance approaches in forest management syst...

Development of a Targeted Choroidal Injury Model for the Study of Retinal Degenerations and Therapeutic Cell Replacement

Purpose: Choroidal loss is an important pathophysiological step in many retinal diseases, but few reliable translational models of choroidal injury exist. Here, we report a new targeted choroidal injury model using bioconjugated saporins and compare it models of systemic sodium i...

Differential associations between social determinants of health and the initiation of medications for opioid use disorder across care settings

Abstract Objective This study investigated associations between social determinants of health (SDoH) and time to MOUD initiation across care settings, providing insights for targeted interventions to promote equitable care for OUD patients. Material and Methods We linked patient-...

Discrete adjoint gradient computation for multiclass traffic flow models on road networks

Abstract This paper applies a discrete adjoint gradient computation method for a multi-class traffic flow model on road networks. Vehicle classes are characterized by their specific velocity functions, which depend on the total traffic density, resulting in a coupled hyperbolic s...

Existence of minimal surfaces in infinite-volume hyperbolic 3-manifolds

Abstract The existence of embedded minimal surfaces in non-compact 3-manifolds remains a largely unresolved and challenging problem in geometry. In this paper, we address several open cases regarding the existence of finite-area, embedded, complete, minimal surfaces in infinite-v...

Decarbonizing construction: a multi-level perspective analysis of green concrete transition in the Netherlands

Purpose The Netherlands is one of the frontrunners in green concrete with innovative pilot projects and institutional settings (e.g. concrete agreement). However, mainstreaming green concrete needs to further overcome economic, institutional, technical and social barriers. Especi...

A serotonergic mechanism is involved in the pro-cognitive effect of AM6545 treatment in a mouse model of fragile X syndrome

Abstract Fragile X syndrome (FXS) is the principal monogenic syndrome leading to inherited intellectual disability and autism. It is caused by the silencing of FMR1 gene that leads to the loss in the expression of its encoded protein, the fragile X messenger ribonucleoprotein 1 (...

Equidistribution of orbits at polynomial times in rigid dynamical systems

We study the distribution of orbits sampled at polynomial times for uniquely ergodic topological dynamical systems ( X , T ) (X, T) . First, we prove that if there exists an increasing sequence ( q n ) (q_n) for which the rigidity condition \[ max t > q n + 1 4 / 5 sup x ∈ X d (...

Flow of power-law fluids in thin straight tubes of non-uniform cross-section

Abstract We analyze the asymptotic behavior of solutions to a boundary value problem describing the flow of a non-Newtonian so-called power-law fluid in a thin tube with a variable cross-section depending on a small parameter $$\varepsilon$$ , representing the ratio between the c...

Volume renormalization of higher-codimension singular Yamabe spaces

Abstract Given an embedded closed submanifold Σ n \Sigma^{n} in the closed Riemannian manifold M n + k M^{n+k} , where k < n + 2 k , we define extrinsic global conformal invariants of Σ by renormalizing the volume associated to the unique singular Yamabe metric with singular set...