Research works

Drosha in mesangial cells regulates glomerular capillary tufts formation through drosha/ribosome/Gata3 axis

Abstract Drosha is a critical regulator of kidney development; its loss or mutation, identified in a subsets of Wilms tumor (WT), a pediatric kidney cancer, leads to nephric cap mesenchyme developmental defects. Here, we investigated the role of Drosha in mesangial cells and its...

Minimal Dispersion on the Sphere

Abstract The minimal spherical cap dispersion $${{\,\textrm{disp}\,}}_{\mathcal {C}}(n,d)$$ disp C ( n , d ) is the largest number $$\varepsilon \in (0,1]$$ ε ∈ ( 0 , 1 ] such that, for every n points on the d -dimensional Euclidean unit sphere $$\mathbb {S}^d$$ S d , there exist...

Extreme Event Aware (η-) Learning

Quantifying and predicting rare and extreme events is challenging because such events are infrequent, severe, and expensive to simulate. Existing data-driven methods often require multiple extremes in the training data or sampling process, leading to accurate predictions in quies...

Neural encoding of symbolic, non-symbolic, and embodied non-symbolic numerical information in young and older adults

Numeracy has important implications across the lifespan, and age-related decline in this ability represents a vulnerability factor for older adults in managing everyday tasks, yet its mechanisms remain poorly understood. This study employed a parity judgment task to examine age-r...

Excited state preparation on a quantum computer through adiabatic light-matter coupling

Abstract Quantum computing has the potential to transform simulations of quantum many-body problems at the heart of electronic structure theory. Efficient quantum algorithms to compute the eigenstates of fermionic Hamiltonians, such as quantum phase estimation, rely critically on...

Unveiling the Immune Mechanisms of Hypertension With Single‐Cell Transcriptome‐Wide Mendelian Randomization

Immune dysregulation is closely implicated in hypertension pathogenesis, yet specific therapeutic targets are lacking. We integrated expression quantitative trait loci (eQTLs) for genes expressed in 14 immune cell subsets (OneK1K) with two-sample Mendelian randomization (MR) and...

Severe Infections as a Novel Risk‐Enhancing Factor for Incident Heart Failure

ABSTRACT Background Severe infections might be a novel risk marker for incident heart failure (HF). We examined the relationship between infection-related hospitalization (IRH) and HF in a large clinical health system and assessed whether adding IRH improved predictive utility of...

High prevalence of resistance to first-line drugs and multidrug resistance in patients with tuberculosis and type 2 diabetes mellitus at a referral hospital in Peru

ABSTRACT Introduction The coexistence of tuberculosis (TB) and type 2 diabetes mellitus (T2DM) poses an emerging public health challenge, especially in high-TB-burden settings such as Peru. This comorbidity has been linked to unfavorable clinical outcomes and a higher likelihood...

Solving Mean-Field Games with Monotonicity Methods in Banach Spaces

Abstract. This paper develops a unified framework for proving the existence of solutions to stationary first-order mean-field games (MFGs) based on the theory of monotone operators in Banach spaces. We cast the coupled MFG system as a variational inequality, overcoming the limita...

Large Language Model for Verilog Code Generation: Literature Review and the Road Ahead

Code generation represents a critical intersection of Software Engineering (SE) and Artificial Intelligence (AI). Within this broader landscape, Verilog, as a representative hardware description language (HDL), is fundamental to Electronic Design Automation (EDA), recent research...

Error Formulas for Block Rational Krylov Approximations of Matrix Functions

Abstract. This paper investigates explicit expressions for the error associated with the block rational Krylov approximation of matrix functions. Two formulas are proposed, both derived from characterizations of the residual of the block full orthogonal method. The first formula...

Bounded diameter monochromatic component covers

Abstract Ryser conjectured that every ‐edge‐coloured complete graph can be covered by monochromatic trees. Motivated by a question of Austin in analysis, Milićević predicted something stronger — that every ‐edge‐coloured complete graph can be covered by monochromatic trees of bou...

Microstructural insights into fast ion transport in solid electrolytes via multiscale modeling

Abstract Improving solid electrolytes is critical for high-performance all-solid-state batteries, yet the microstructural features that enable fast ion transport remain poorly understood. Here, we use multiscale modeling to resolve polycrystalline ion transport from atomic-scale...

A Paley–Wiener–Schwartz Theorem for Smooth Valuations on Convex Functions

Abstract Continuous dually epi-translation invariant valuations on convex functions are characterized in terms of the Fourier–Laplace transform of the associated Goodey–Weil distributions. This description is used to obtain integral representations of the smooth vectors of the na...

Relationships between Arctic sea-ice concentration, temperature, and specific humidity in the lower troposphere during 1980–2021

Abstract. Understanding of the local effects of sea-ice concentration (SIC) variations on the Arctic atmosphere is a prerequisite for assessing the role of Arctic sea-ice decline in the climate system, including its influence on mid-latitudes. In this study, we analysed the relat...

Ergodic control of multi-agent systems under communication constraints

We study decentralised ergodic control for multi-agent systems operating over stochastic, lossy communication graphs. Each agent follows controlled stochastic dynamics with uniformly elliptic noise on a compact domain and aims to align its occupation measure with a prescribed tar...

Gradient Regularity for Double-Phase Orthotropic Functionals

We prove higher integrability for local minimizers of the double-phase orthotropic functional [Formula: see text] when the weight function [Formula: see text] is assumed to be [Formula: see text]-Hölder continuous, while the exponents [Formula: see text] are such that [Formula: s...

Cube structures of the universal minimal system, nilsystems and applications

We propose and develop an approach to study nilsystems and their proximal extensions using cube structures associated with the universal minimal system. We provide alternative proofs for results regarding saturation properties of factor maps to maximal nilfactors in cubes, as wel...

A theory of political divergence and gradual institutional change

Abstract Why do some societies succeed in breaking away from historical traditions while others remain trapped? This paper proposes a formal theory to investigate the interaction between short‐run and long‐run political dynamics, highlighting a co‐evolution of political instituti...

Cobalt-catalyzed construction of spiro scaffolds bearing central and axial chirality via enantioselective (4+1) C–H spiroannulation

Abstract The construction of structurally complex, stereochemically rich spirocyclic frameworks remains a formidable challenge in organic synthesis, particularly when multiple stereoelements installed with precision in a single operation. Herein, we disclose a cobalt/Salicyloxazo...