Research works

Characterising caregivers’ contingent responses: Short, slow, and clear speech facilitates infant turn-taking

Bidirectional temporal contingency in infant-caregiver interaction is believed to be instrumental in shaping the development of turn-taking and speech. Likewise, caregivers are known to modulate their voices in a distinctive register when speaking to infants. Yet, less is known a...

The Effectiveness of the Discovery Learning with an Ethnomathematics Focus on Ratu Boko Temple on Students' Learning Achievement and Self-Efficacy

The purpose of this study was to examine the effect of a discovery learning approach with an ethnomathematics focus on students’ learning achievement and self-efficacy. This study was conducted during the 2024–2025 school year with eighth-grade students at a junior high school in...

Al-Ghayb, A Formal Mathematical Definition of the Unseen

The Qur'anic concept of al-ghayb (the Unseen) is central to Islamic theology, but scholarship usually treats it through exegetical, theological, mystical, or anthropological analysis. This paper develops a formal, time-indexed model separating actual discovery from accessibility...

Photometallobiocatalytic Asymmetric Radical‐Mediated Cross‐Coupling of Organotrifluoroborate Salts and Pyridotriazoles

ABSTRACT The cooperative integration of photoredox catalysis and metalloenzyme catalysis has emerged as a powerful strategy for enabling stereoselective radical transformations beyond the capabilities of either catalytic mode alone. Herein, we report a photometallobiocatalytic en...

Institutionalizing LLM-assisted decision support for malaria risk-focused ITN reprioritization in Nigeria: Digital competency, workplace resource profiles, experiences, and pathways to routine integration

Background In Nigeria, the country with the greatest global malaria burden, funding constraints increasingly require insecticide-treated net (ITN) reprioritization to target those at highest risk. Large language models (LLM)- assisted decision-support tools may facilitate risk-in...

Pre-Governance in Production: A Single-Operator Case Study of Constraint-First Governance at the Deployment Decision Surface

v1.1 (2026-08-22) withdraws this study's expiry findings. The status recorded as EXPIRED in the governance trace denotes a consumed approval, not an unadjudicated timeout: it is written when an escalation is approved, to spend a one-time approval. The timeout path writes a differ...

Concurrent Peripheral Arterial Disease Predicts Re-Intervention Following Abdominal Aortic Aneurysm Repair: A Single-Centre Propensity Matched Retrospective Study

Purpose: Abdominal aortic aneurysm (AAA) and peripheral arterial disease (PAD) share common risk factors and may co-exist in patients undergoing AAA repair. The impact of concomitant PAD on clinical outcomes post AAA repair remains unclear. This study aims to evaluate whether con...

Comparing the readability of AI-generated and society-authored patient information leaflets in orthopaedics

Abstract Introduction Effective patient education is critical in orthopaedic care, influencing satisfaction, adherence, and outcomes. Artificial intelligence (AI), particularly large language models (LLMs), could offer the potential to improve patient information leaflets (PILs),...

Understanding bowel cancer screening behaviour and intention across British, Indian, and Indian-Immigrant populations: A qualitative cross-cultural comparison

Bowel cancer screening reduces mortality, yet uptake remains suboptimal across many populations. While disparities in participation are well documented, limited qualitative research has explored how cultural and healthcare contexts shape attitudes towards screening and preventive...

Delay Differential Equation Approach to Oligomerization Reveals the Delay Dynamics Underlying Oscillations in Mitochondrial Fission

Abstract Disruptions in the balance of mitochondrial fission and fusion are implicated in a host of diseases including cardiovascular, metabolic, and neurodegenerative, as well as cancer. Leinheiser et al. proposed a mechanistic model for mitochondrial fission which relies on the...

Bacterial quorum sensing signals reshape phycosphere functions to regulate colony morphology in Phaeocystis globosa

Phaeocystis globosa exhibits a complex life cycle alternating between solitary cells and colonial forms. Although phycosphere bacteria have been implicated in bloom dynamics, the factors that mediate bacterial behaviour to influence colony formation, as well as how bacterial quor...

How Does Motion-to-Photon Latency Influence the Perception-Action Loop

The perception-action loop plays an essential role in sports performance. Virtual reality is increasingly used to train this loop because it provides a controlled setting. However, motion-to-photon latency, the delay between the user’s real and virtual motion, may disrupt user ex...

Gender Bias in Clinical Diagnosis of Borderline Personality Disorder and Autism Spectrum Disorder: A Retrospective Cohort Study

Background: Autism spectrum disorder (ASD) and borderline personality disorder (BPD) share overlapping clinical features including social cognitive differences, interpersonal difficulties, emotional dysregulation, and alexithymia. The two conditions show different gender prevalen...

Behaviorally Free, Ontologically Determined: Consciousness and Decision as Self-Directed Modelling Residual in Quantum-Geometry Dynamics

Quantum-Geometry Dynamics (QGD) admits no exception to bottom-up determinism: Axiomatic Localism establishes that every causal succession is exhaustively fixed by local preonic configuration. There is no causal slack and no abstract causal layer through which mental states, inten...

Existing molecular biology indicates a path to biological immortality

This preprint argues that complementary single strand lesions (CSSLs) are the primary irreversible form of nuclear DNA damage driving aging. A simple Bayesian model using average literature values for daily new damage (~70,000 lesions/cell) and steady damage (~38,000 lesions/cell...

The Embodied Relational Constructivist Self-Framework (ERCS): An Integrative Conceptual Framework for Developmental Psychology

This theoretical review introduces the Embodied Relational Constructivist Self-Framework (ERCS), an integrative developmental framework linking constructivist, self-psychological, attachment-theoretical and embodied-cognition traditions. The paper is the first article in a planne...

ALDH2 inhibition reprograms tubular epithelial cell metabolism and promotes renal injury susceptibility

Fatty Acid Oxidation (FAO) dysfunction induces pro-fibrotic transition in tubular epithelial cells (TECs) and contributes to renal fibrosis in chronic kidney disease (CKD); however, the drivers of metabolic reprogramming in TECs remain unclear. We investigate the role of aldehyde...

Strategic roadmap for delivery of clinical trials in rare childhood central nervous system (CNS) tumours: a multi-stakeholder consensus

Abstract Rare paediatric central nervous system (CNS) tumours comprise a biologically-heterogeneous group of low-incidence diseases that present significant challenges to both therapeutic development and clinical research, limiting the availability of high-quality evidence to gui...

Pressure Gradient Driven Multistage Leak Localization for Multiple Simultaneous Leaks in Water Distribution Networks under Uncertainty

Abstract Leak localization in water distribution networks (WDNs) is inherently challenging due to the nonuniqueness of solutions, where different leak configurations can produce similar pressure responses at monitoring sensors. These challenges are further exacerbated by uncertai...

Asian summer monsoon orbital variability directly paced by CO2 and precession, not eccentricity

Abstract The pacing and intensity of the Asian summer monsoon have long been debated. Geological records indicate either a dominant precession or eccentricity variability, while modelling studies have largely emphasised monsoon intensity rather than its temporal pacing. Here, we...