Research works

An Exact Non-Symmetric Strong Spectral Criterion for Root-Loop Spider Matrices

For an arbitrary real root-loop bidirected spider matrix, we prove that the non-symmetric strong spectral property holds exactly when the characteristic polynomials of the root-deleted arms are pairwise coprime. The criterion permits non-symmetric weights, negative directed edge...

Integrating deep learning and pangenomics to recover missing heritability from wild structural variations

Crop domestication has induced a severe genetic bottleneck that reduces the adaptive diversity present in modern cultivars. Standard intra-population genomic prediction models reliant on linear reference genomes and SNPs fail to capture the full spectrum of phenotypic variance hi...

The hDPSC-CM-derived peptide P1DC promotes osteogenic differentiation by regulating the p38/MAPK pathway

Human dental pulp stem cells (hDPSCs) are dental-derived mesenchymal stem cells with robust multipotent differentiation potential, indicating that they are promising for bone tissue engineering (BTE). We previously screened a secreted peptide, P1DC, derived from differentiated hD...

AGV: a web-based visualization tool for reconstructed ancestral genomes

The ancestral genome is the genome of the common ancestor of extant species. Ancestral genome reconstruction infers evolutionary events from extant genomes to recover the genomic states of extinct ancestors. Although this approach provides a powerful framework for studying genome...

Exploration and practice of a DeepSeek‑enhanced, scenario‑based teaching model integrated with a multidisciplinary team approach in gastroenterology residency training

The first year of standardised residency training is a critical transition from medical student to clinical practitioner, during which trainees struggle to integrate theoretical knowledge with clinical competencies. Traditional teaching often lacks active learning and authentic c...

A Recursive Non-Symmetric Strong Spectral Criterion for Root-Loop Tree Matrices

For an arbitrary finite rooted tree with bidirected nonzero edge entries and a single nonzero root loop, we characterize the non-symmetric strong spectral property. It holds exactly when, at every vertex, the characteristic polynomials of the complete child subtrees are pairwise...

Behavioral and neural effects of right temporoparietal junction itbs during empathy processing in women

The right temporoparietal junction (rTPJ) is one neural region that has been implicated in empathy in previous studies. However, prior findings regarding its role have been inconsistent. Moreover, methodological limitations in earlier research, including the use of suboptimal emp...

Effect of Angulated Screw Channel (ASC) design on the fracture resistance of implant-supported monolithic zirconia and lithium disilicate crowns: an in vitro study

Ti-base abutments with angulated screw channel (ASC) designs have been developed to address the esthetic challenges associated with labial screw access in anterior implant-supported single crowns, as well as the ergonomic limitations caused by restricted mouth opening in posterio...

Ajuga reptans L. from Romanian flora as a promising candidate for novel food applications

The increasing demand for natural ingredients with both functional and sensory properties has stimulated the exploration of underutilised plant species as potential sources for novel food applications. Ajuga reptans L. (Lamiaceae) remains relatively underexplored despite its phyt...

Predictors of hysterectomy during myomectomy: a retrospective cohort study

This study aimed to determine the risk of unplanned hysterectomy during myomectomy and identify factors associated with this risk. A total of 1,368 patients who underwent myomectomy at four hospitals in Osmaniye Province, Türkiye, between January 2014 and December 2025 were retro...

Neutropenia events with androgen receptor pathway inhibitor-containing versus control therapies in prostate cancer patients: a systematic review and meta-analysis

To systematically evaluate the risk of neutropenia associated with androgen receptor pathway inhibitor (ARPI) intensification in patients with prostate cancer across phase 3 randomized controlled trials. This systematic review and meta-analysis was conducted in accordance with PR...

Impact of Menopause and Menopausal Hormone Therapy on Liver–Kidney–Metabolic Health

Menopause is associated with unfavorable metabolic changes that may contribute to the development of metabolic dysfunction-associated steatotic liver disease (MASLD), chronic kidney disease (CKD), and increased cardiometabolic risk. Within the evolving cardiovascular-kidney-metab...

3D-printed biochemical–biomechanical gradient scaffolds from high internal phase Pickering emulsion with dual gelatin-modulated gelling kinetics for enhanced osteochondral regeneration

Three-dimensional (3D) printing enables the precise design of biomaterials at predefined spatial locations, representing a promising strategy for constructing highly organized osteochondral tissue with multiple morphogen gradients. However, most current 3D printing strategies lim...

Alcohol reshapes liver zonal plasticity and immune-metabolic reprogramming in metabolic-syndrome associated hepatocellular carcinoma

Hepatocellular carcinoma (HCC) commonly arises in metabolic dysfunction-associated steatohepatitis (MASH), alcohol-related liver disease (ALD), and metabolic dysfunction-associated ALD (MetALD), yet how zonal metabolic programs govern tumor lineage and immune responses remains un...

MRI-derived lumbosacral cerebrospinal fluid volume influences both the extent and persistence of spinal anesthesia: a prospective observational study

Considerable interindividual variability exists in the spread and duration of spinal anesthesia despite standardized anesthetic techniques. Lumbosacral cerebrospinal fluid (CSF) volume has been proposed as an important anatomical determinant of neuraxial block characteristics. Ho...

Acute toxicity and tissue deposition of graphene oxide decorated with platinum nanoparticles following intraperitoneal administration in rats

Recently developed novel graphene oxide decorated with platinum nanoparticles (GO/PtNPs) has been recognized for its anticancer properties. Therefore, in vivo studies assessing the toxicity and tissue deposition of these particles are needed. Using a fixed-dose acute toxicity des...

Feasibility and acceptability of adding peer support to a school-based nurse-led smoking cessation intervention among male adolescents in Pakistan: a pilot cluster-randomized trial

Reducing adolescent smoking is a global health priority. School-based, nurse-led interventions show promise, yet most studies have been conducted in Western and other high-income countries. This study assessed the feasibility and acceptability of a school-based, nurse-led smoking...

Integration of principal component analysis and supervised classification for mineral alteration mapping using satellite imagery, Kafta Humera, Ethiopia

Remote sensing is an important technique for lithological mapping and hydrothermal alteration detection; yet, achieving high classification accuracy remains difficult in complex geological environments. This study addresses the difficulty of delineating lithological units and alt...

Geometric Dynamics Unified Theory (GDUT)

Current physics faces several fundamental unresolved problems: the lack of direct observational evidence for dark matter; a discrepancy of approximately 120 orders of magnitude between predicted and observed values for dark energy; unresolved tensions in the Hubble parameter; and...

Entropy aware EnKF framework for reliable power quality prediction in smart grids

In this paper a novel predictive technique is proposed for power quality (PQ) event classification in smart grid. Here Ensemble Kalman filter (EnKF) based approach and Entropy based trust modelling are utilized to design hybrid learning model that can classify PQ events during no...