Research works
The research papers we track — the newest first. Works with a plain-language summary link to it.
78092 work(s)
- Health & MedicineOpen access
SUMMARY While nucleoside DNA methyltransferase inhibitors (DNMTi) such as decitabine and azacitidine are effective in treating myelodysplatic syndrome (MDS)/leukemia, they have had limited utility for the majority of other cancers. Through a chemical library screen, we identified...
- BiologyOpen access
Background and aimsEscapism is a key gaming motive associated with both psychological relief and Gaming Disorder. Yet, existing models often neglect the dynamic role of goal attainment in shaping gaming outcomes. Drawing on Goal Systems Theory, we introduce the construct of Post-...
- Society & EconomicsOpen access
Freud's Oral Fixation as Self-Projection: A Carlo-Domain Reconstruction of Psychoanalytic Error
This work presents the first structural, mechanistic reinterpretation of Freud’s oral fixation theory using Carlo-domain mapping. Drawing directly from Freud’s own symbolic emissions, the paper demonstrates that what Freud believed to be universal developmental laws were in fact...
- BiologyOpen access
The Variant Call Format (VCF) is the de facto standard for reporting genomic variants, but its permissive specification and the length of the sequencing-to-variant-calling pipeline leave room for malformed, internally inconsistent, or reference-discordant files to propagate into...
- Health & MedicineOpen access
Abstract Purpose Reliable biomarkers for tracking Parkinson’s disease (PD) progression remain an unmet clinical need. Quantitative susceptibility mapping (QSM), an MRI technique sensitive to iron-related susceptibility changes, has emerged as a promising candidate biomarker; howe...
- AI & ComputingOpen access
Learned world models increasingly empower autonomous agents to predict transitions, imagine rollouts, and plan behaviors in complex environments. However,conventional continual world modeling paradigms predominantly formulate lifelong adaptation along a single parametric axis: up...
- Society & Economics
WHEN DO BOUNDARY SPANNERS TRANSFER AND CREATE KNOWLEDGE?: THE ROLE OF NETWORK CENTRALITY
Innovation requires not only the exploitation of existing knowledge but also the exploration of new knowledge across organisational boundaries. However, when firms differentiate their research and development (R&D) organisations and different norms are consequently formed, invent...
- Health & MedicineOpen access
Abstract Purpose To evaluate and compare six-month clinical outcomes between uveitis patients with positive versus negative Interferon-Gamma Release Assay (IGRA) results, focusing on treatment success and complication rates. Methods This prospective exploratory cohort study enrol...
- Health & MedicineOpen access
Abstract Background This study examines whether migration background, health literacy, and religious–spiritual orientation are associated with the use of traditional, complementary and integrative medicine (TCIM). In addition, the relationship between religious–spiritual orientat...
- AI & ComputingOpen access
Hamilton Cycles and Paths in the Noncrossing Partition Refinement Graph
Let NCR(n) be the cover graph of the refinement order on the noncrossing partitions of an n-element cyclically ordered set. We determine exactly when this graph has a Hamilton cycle and when it has a Hamilton path. The graph has a Hamilton cycle exactly for n in {0,1} or even n a...
- BiologyOpen access
A Minimal Machine Thesis of the Functional Present
ENGLISH Conceptual hypothesis; not empirical evidence. This bilingual technical note proposes a minimal functional architecture for a machine “present.” The present is modeled as a single active, body- and energy-bound focus organized relative to a persistent, content-empty deict...
- BiologyOpen access
A rigorous analysis of the current technological landscape (as defined by mainstream institutional and corporate projections in 2026) compared to the operational V-PRIMA architecture reveals a severe chronological and ontological divergence. The standard development vector relies...
- Engineering & Technology
Abstract The increasing occurrence of ground sinking in metropolitan cities due to excavation-induced backfill instability has raised significant safety concerns. Conventional compacted soils used for backfilling underground utilities often fail to provide adequate support, leadi...
- Biology
Context The expansion of the agricultural frontier in northwestern Argentina occurred at the expense of deforestation of native forests, particularly in the Dry Chaco. This land-use change alters soil physical properties and soil organic carbon (SOC), compromising sustainability....
- AI & ComputingOpen access
Repeated-Endpoint Canon Permutations: Cone Walks and Spectral Geometry
This preprint solves the intermediate repeated-endpoint enumeration for canon permutations by a multichain recurrence and cone-walk model. It proves upper-boundary non-D-finiteness and exact asymptotics, and develops the associated harmonic-kernel and higher-dimensional spectral...
- AI & ComputingOpen access
Open Quantum: An Open Infrastructure Layer for Quantum Computing
Open Quantum is a platform that provides researchers and developers with access to quantum processing units (QPUs) from multiple hardware providers through a unified API and native integrations with widely used quantum programming frameworks, including Qiskit and PennyLane. The p...
- BiologyOpen access
Abstract Autistic children and adolescents often encounter social, sensory, and environmental barriers to participation in group-based physical activity. This study evaluated the feasibility, safety, and participation-related processes of a community-based inclusive physical acti...
- Society & EconomicsOpen access
Freud's Oral Fixation as Self-Projection: A Carlo-Domain Reconstruction of Psychoanalytic Error
This work presents the first structural, mechanistic reinterpretation of Freud’s oral fixation theory using Carlo-domain mapping. Drawing directly from Freud’s own symbolic emissions, the paper demonstrates that what Freud believed to be universal developmental laws were in fact...
- Health & MedicineOpen access
G3BP1 depletion, observed in Parkinson’s Disease, drives Golgi–lysosome–autophagy defects
Abstract The RNA binding G3BP1 is depleted in several neurodegenerative diseases, yet its functional consequences at the cellular level remain poorly understood. While best known for its critical role in stress granule formation, we demonstrate that G3BP1 also stabilises the COPI...
- Health & MedicineOpen access
Abstract Physical inactivity and increasing obesity among college students are major public health concerns. Although physical fitness is closely related to body mass index (BMI), the combined predictive value of multiple fitness components remains unclear. Purpose: This study in...