Research works

Time‐Aware UNet and Super‐Resolution Deep Residual Networks for Spatial Downscaling

ABSTRACT Satellite observations of atmospheric pollutants are often available only at coarse spatial resolution, which limits their use in local‐scale environmental analysis. Spatial downscaling methods aim to transform such data into high‐resolution fields. In this work, two wid...

Phagocytosis of microbial symbionts supports embryonic nutrition in the sponge Halichondria panicea

Abstract Animals associate with microbial symbionts that play crucial roles in their nutrition and development, yet their function during gametogenesis and embryogenesis remains poorly understood. Here, we investigate host–symbiont dynamics throughout the reproductive cycle of th...

Simulation-based inference of epidemiological and phylodynamic models via neural posterior estimation

Mathematical models play a central role in understanding and forecasting infectious disease dynamics, but parameter inference is often difficult when likelihoods are intractable. Simulation-based inference (SBI) circumvents this limitation by relying on model simulations. Traditi...

Moonlighting and the transition to full-time entrepreneurship

Abstract This paper examines the transition from moonlighting to full-time self-employment using panel data from the Survey of Income and Program Participation. Motivations for moonlighting vary—from financial necessity to entrepreneurial experimentation—and these motivations sha...

A bundled anti-parallel cytochrome nanowire structure suggests roles in cell-cell electron transfer and biofilm formation

ABSTRACT Long-range extracellular electron transfer enables respiring microbes to use minerals, organisms, or electrodes as electron acceptors by transporting electrons microns away from the cell surface. This process is primarily studied in Geobacter sulfurreducens , which produ...

Modeling the influences of non-local connectomic projections on geometrically constrained cortical dynamics

The function and dynamics of the cortex are fundamentally shaped by the specific wiring configurations of its constituent axonal fibers, also known as the connectome. However, many dynamical properties of macroscale cortical activity are well captured by instead describing the ac...

On the non-linear response of Antarctic ice shelf surface melt to warming

Abstract. Surface meltwater can saturate firn, form melt ponds, and trigger hydrofracturing of Antarctic ice shelves, ultimately accelerating grounded ice flow and contributing to sea level rise. Although the response of surface melt to atmospheric warming (expressed by near-surf...

Fusion-driven oncogenic programs shape the immune landscape in translocation renal cell carcinoma

Renal cell carcinomas comprise multiple molecularly distinct cancers but most are treated empirically with therapies designed for clear cell RCC (ccRCC), the most common subtype, due to incomplete understanding of subtype-specific biology. We analyzed single-cell transcriptomes a...

Targeted Analysis of Chondrocyte Central Metabolites in Response to Cyclical Compression and Shear Deformations

Osteoarthritis results in deterioration of articular cartilage, the soft tissue covering articulating surfaces of bones in joints like the knee and hip. Cyclical mechanical stimulation of articular cartilage results in synthesis of cartilage matrix, suggesting that therapeutic me...

Uncovering dynamic human brain phase coherence networks

Abstract Complex cognitive functions rely on coordinated communication between distributed brain regions, yet capturing these interactions as they evolve over time remains challenging. Traditional analyses of functional brain connectivity largely rely on correlations in signal am...

Managing Perishable Inventory Systems with Positive Lead Times: Inventory Position vs. Projected Inventory Level

We study periodic review perishable inventory systems with a fixed product lifetime, positive replenishment lead times, and a general issuance policy under the average cost criterion. The optimal replenishment policy for such systems is notoriously complex and computationally int...

A cortical output channel for perceptual categorization

Abstract Perceptual categorization allows the brain to transform diverse sensory inputs into discrete representations that support flexible behavior [1–7]. Auditory cortex (ACtx) has been implicated in this process [8–14], but the cell-type-specific circuits that implement catego...

Methadone-Based Enhanced Recovery after Surgery Protocol in DIEP Flap Breast Reconstruction: A 4-Year Analysis

Background: This study evaluates the effectiveness of the New York--Presbyterian/Weill Cornell methadone-based enhanced recovery after surgery (ERAS) protocol in reducing postoperative pain and narcotic consumption in patients undergoing deep inferior epigastric perforator flap b...

The MESA Framework: A Four-Altitude Diagnostic Model for Institutional AI Governance

Institutional AI governance is commonly assessed as a single capability and reported as a single grade. That treatment obscures the failure that matters most: an institution can hold current policies, a chartered committee and a complete documentation set while the systems those...

Truthful visualizations for mass spectrometry imaging enable high-spatial-resolution interactive m/z mapping and exploration

Mass spectrometry imaging (MSI) produces high-dimensional molecular data, but practical interpretation remains limited by visualizations that incompletely preserve global structure. We present MSI-VISUAL, an open-source framework for interactive MSI analysis that integrates truth...

The Authorization Boundary Integrity Model

A complete authorization boundary satisfies three independent properties. Most architectures satisfy one or two and present as complete. This work names the construct and the properties, and gives a way to see which one a given architecture is quietly missing. The model is stated...

The Four-Model Theory of Consciousness: A Simulation-Based Framework Unifying the Hard Problem, Binding, and Altered States

The science of consciousness remains in a pre-paradigm state, with no theory simultaneously satisfying the eight core requirements a complete theory must meet: the Hard Problem, the Explanatory Gap, the Boundary Problem, the Structure of Experience, Unity and Binding, Combination...

STcompare: comparative spatial transcriptomics data analysis of structurally matched tissues to characterize differentially spatially patterned genes

Abstract Motivation Comparative analysis of spatial transcriptomics (ST) data is needed to identify genes that spatially change in their expression patterns between conditions, such as in diseased versus healthy tissues. Existing methods generally fail to distinguish changes in s...

Theoretical and Methodological Insights From Five Transcribed and Annotated Daylong Audio Recordings of Young Children’s Language Environments

As we come to appreciate the role that the language environment plays in language learning, there is an increased interest in measuring children’s auditory input. Recording methods that capture a full day’s worth of a child’s auditory environment are increasingly available to res...

Post launch spectral and radiometric performances of MAJIS, the VIS-NIR imaging spectrometer of JUICE

Abstract. The post-launch spectral and radiometric performances of MAJIS, the VISNIR imaging spectrometer of the ESA Jupiter Icy Moon Explorer (JUICE), have been evaluated using observations performed during the Lunar-Earth Gravitational Assist (LEGA) of 19–20 August 2024 and obs...