Research works

Geometric inverse semigroup theory: a note on the Milnor–Schwarz lemma for inverse monoids

Abstract We generalise the Milnor–Schwarz lemma to inverse monoids acting on presheaves of geodesic metric spaces. We provide two proofs of this fact: one only uses elementary techniques, inspired by the arguments for group actions on metric spaces; the other involves a version o...

Optimised murine model of influenza-induced respiratory sepsis for studying acute kidney injury

Abstract Background Viral respiratory sepsis, driven by influenza and COVID-19, is increasingly prominent clinically. However, there is a lack of preclinical models that reliably replicate its associated acute kidney injury (AKI), a major contributor to morbidity and mortality. M...

E-values as statistical evidence: a comparison to Bayes factors, likelihoods, and p-values

Abstract A recurring debate in the philosophy of statistics concerns what, exactly, should count as a measure of evidence for or against a given hypothesis. P-values, likelihood ratios, and Bayes factors all have their defenders. In this paper we add two additional candidates to...

A striking mismatch between genomic and phenotypic selection responses– the role of pleiotropy in complex environments

Abstract Background A major focus of evolutionary biology is the characterization of the genetic basis of adaptation. A widely used approach builds on the comparison of allele frequencies among populations adapted to different environments, reasoning that differentiated loci unco...

TCOM-CFC11 and TCOM-CFC12: a gap-free, observationally constrained global dataset of stratospheric CFC-11 and CFC-12 profiles (v2.0)

Abstract. Understanding the long-term trends of ozone-depleting substances (ODSs), particularly CFC-11 (CFCl3) and CFC-12 (CF2Cl2), is essential for evaluating the effectiveness of the Montreal Protocol. However, reliably estimating these trends is complicated by the inherent spa...

Ecosystem services and livelihood pathways: the nexus between biodiversity governance and environmental justice in rural Eastern Cape, South Africa

Mountain ecosystems in sub-Saharan Africa provide critical services such as water regulation, soil fertility, and biodiversity conservation, yet they face increasing vulnerability from climate variability and weak governance. This study examined how climate change, governance str...

Mucosal IgA to pre-fusion F protein predicts protection from RSV infection in a high burden setting

ABSTRACT Respiratory syncytial virus (RSV) causes over 100,000 annual deaths, predominantly in low-and middle-income countries, yet immunological correlates of protection remain poorly defined in high-burden settings. We conducted an intensively sampled prospective household coho...

Geodesic costs on a scalar field over the periodic table predict diatomic bond dissociation energies

Abstract We construct a scalar configuration field $$\Phi $$ on the periodic table lattice from z -score-normalized first ionization energy and covalent radius, with a single coupling parameter $$\lambda $$ fixed a priori . Geodesic costs computed on this field via Dijkstra’s alg...

Functional Evolution and Modular Behaviour in the Carnivoran Mandible

The relationship between form and function holds a central spot in evolutionary biology, as the changes in such relationship through time, are likely to deeply influence how organisms adapt to the surrounding environment. However, anatomical structures may be interpreted as a com...

Normalization as Query: The Geometric Essence of Neural Network Representations

Normalization layers (LayerNorm, BatchNorm, RMSNorm) are commonly regarded as engineering tricks for stabilizing training. This paper proves that normalization layers mathematically enforce a decomposition of hidden states into direction and magnitude, thereby establishing the No...

Families of Two-Impulse Optimal Rendezvous Transfers Between Elliptic Orbits

Abstract The classical fuel-optimal two-impulse rendezvous problem between Keplerian orbits is revisited from a family-based perspective. Conventional approaches often yield isolated optimal solutions whose mutual relationships remain unclear; yet, when re-parameterized appropria...

Organic carbon pathways across the fluvial-marine transition zone of the Mackenzie River Delta – Beaufort Sea region and implications on ocean color remote sensing

Abstract. Arctic warming and hydrological intensification are accelerating permafrost thaw and increasing the export of terrestrial organic carbon (OC) and sediments from land via rivers and shallow coastal waters into marine waters, yet the fate of these materials in deltaic and...

Magma-induced midcrustal flow and high-temperature metamorphism: Insights from the early Mesozoic Yunkai massif (South China) and tectonic implications

The way in which partial melting weakens the middle continental crust and triggers lateral flow is fundamental to understanding orogenic processes, yet the specific roles of magmatic heat and deformation remain debated. We addressed this issue through an integrated study of the e...

ODIN: Confirmation and 3D Reconstruction of Six Massive Protoclusters at Cosmic Noon

Abstract Protoclusters represent sites of accelerated galaxy formation and extreme astrophysical activity characteristic of dense environments. Identifying massive protoclusters and mapping their spatial structures are therefore crucial for understanding how large-scale environme...

Numerical simulations of inorganic HTL-free perovskite Cs2PtI6 solar cell using SCAPS-1D

Abstract This study utilizes the SCAPS-1D to conduct a numerical simulation of lead-free solar cell device based on Cs 2 PtI 6 . We aim to explore the impact of eliminating hole transport materials (HTL) on the device's performance while ensuring high efficiency and stability. Th...

Transferable Optimization Network for Cross-Domain Image Reconstruction

Abstract. We develop a novel transfer learning framework to tackle the challenge of limited training data in image reconstruction problems. The proposed framework consists of two training steps, both of which are formed as bilevel optimizations. In the first step, we train a powe...

Development of a Photostable pH Biosensor Based on mStayGold

Fluorescent proteins (FPs) that are pH-sensitive play a crucial role in investigating pH-related cellular processes, such as endocytosis and exocytosis. Existing pH-sensitive FPs generated from Aequorea victoria green fluorescent protein (GFP), such as superecliptic pHluorin (SEP...

Outcomes of modified pneumatic retinopexy with transscleral subretinal fluid drainage for primary rhegmatogenous retinal detachment

Abstract Background Primary rhegmatogenous retinal detachment (RRD) occurs when a retinal tear or break causes fluid from inside the eye to seep behind the retina, which pushes it away from the wall of the eye. This can cause permanent vision loss if not treated. Which of three c...

OncoRAG: graph-based retrieval enabling clinical phenotyping from oncology notes using local mid-size language models

Abstract Oncology notes contain the richest clinical detail, yet they remain largely inaccessible at scale because extracting structured phenotypes requires either substantial language model infrastructure, curated training data, or cloud computing under regulatory constraints. W...

System-size dependence of charged-particle suppression in ultrarelativistic nucleus-nucleus collisions

High-energy partons lose energy while propagating through the hot, strongly interacting medium produced in ultrarelativistic nucleus-nucleus collisions, leading to a suppression of particle production at high transverse momentum (p(T)). The dependence of this energy loss on the s...