Research works

Secondary prevention of cancer therapy-induced thrombocytopenia with hetrombopag in breast cancer: a multicenter, randomized, exploratory phase II trial

Abstract Background: Cancer therapy-induced thrombocytopenia (CTIT) is a common complication of anti-tumor therapy, leading to treatment delays or interruptions, increased bleeding risk and compromised outcomes. In the present study, we aimed to evaluate the efficacy and safety o...

From regular to random: a unifying framework for step-pool spacing

Abstract. Steep streams frequently display a distinctive step-pool structure where water crests over a near-vertical drop and plunges into a deeper depression in a repeated pattern. Because they naturally moderate the flow of water and sediment in hazardous mountain catchments, s...

Multi-model high-resolution analysis of Tropical-Like Cyclone Daniel with WRF and ICON: peculiarities and sensitivity to convection schemes

Abstract. Medicane Daniel (September 2023) featured a rapid transition from a baroclinic disturbance to a compact tropical-like vortex, challenging short-range prediction. This study delivers a side-by-side, high-resolution (∼2 km) assessment of Daniel using two state of the art...

Updating the holomorphic modular bootstrap

A bstract We update the holomorphic modular bootstrap incorporating a recent result that computes the exact S -matrix within the Modular Linear Differential Equation (MLDE) setting. Further, using knowledge of the allowed exponents modulo one, we obtain admissible solutions to al...

Constraining new physics in charm quark associated Higgs boson production events using the Standard Model effective field theory approach

A bstract As the search for observable deviations from the Standard Model of particle physics remains to be of significant interest, effective field theory (EFT) continues to be a popular method to parametrize such effects. In this work, a first-time investigation is performed of...

Artificial Intelligence and Machine Learning for Identifying Social Determinants of Health in Low‐Income Populations Within United States Health Systems: A Scoping Review

ABSTRACT Background and Aims Low‐income populations in the United States experience disproportionate exposure to adverse social conditions. This scoping review examined artificial intelligence (AI) and machine learning (ML) approaches used in United States health systems to ident...

Pre-Operative Education in Breast Surgery: a Quality Improvement Project

OBJECTIVE: Effective patient education before surgery is a critical component of care that impacts patient outcomes, satisfaction, and overall surgical success. Lack of standardization of this education and prolonged time between pre-operative consults and surgery could result in...

An $$A_4$$ model to accommodate maximal $$\theta _{23}$$ and maximal $$\delta $$ consistent with $$\mu $$–$$\tau $$ reflection symmetry

Abstract In this work, we construct an $$A_4$$ A 4 -based flavor symmetry model within the framework of the type-I seesaw mechanism to realize a light neutrino mass matrix consistent with $$\mu $$ μ – $$\tau $$ τ reflection symmetry. The entire framework is based on the Standard...

The influence path of the homogenization management level of medical services in county-level medical communities on the medical service capabilities of township health centers

Abstract Objective This study elucidates the relationship between the level of homogeneity management in county-level community healthcare services and the medical service capacity of township health centers. and constructs an influence path model. It aims to promote the coordina...

Interhemispheric perspective on the most extreme surface winds in the storm tracks

Abstract. Extratropical cyclones occur most frequently over the oceans, where they cause the strongest extreme surface winds. In this study, we investigate extreme surface winds during winter months in the Northern and Southern Hemispheres, when the wind storms are the strongest....

Assessing financial risk to property portfolios from physical rainfall extremes

Abstract. Physical climate risk from extreme rainfall is often poorly understood by financial investors, potentially extending to pension funds that manage assets of substantial societal importance. There is a growing need for investors to better understand these risks to ensure...

Cardiac tertiary immune niches drive immune activation in immune checkpoint inhibitor myocarditis

Immune checkpoint inhibitor (ICI) myocarditis is a rare but frequently fatal immune-related adverse event of cancer immunotherapy. Understanding the mechanisms of this toxicity is critical to balancing treatment with maintenance of antitumor immunity. Using integrated spatial and...

Optimal sequential change-point detection for Markov models under probability criteria over short time intervals

In this paper, we study sequential change detection problems in the Bayesian framework under the probability delay risk according to which the detection goal is to minimize the probability that the detection delay will exceed some admissible delay level. To do this, we represent...

Perspective Shift Technique: A Clinical Method for Perspective-Based Memory Updating in Hypnotherapy

This paper introduces the Perspective Shift Technique (PST; 人格移動, jinkaku idō), a clinical method developed by the present author, in which a client experientially inhabits a perspective attributed to another person from within a hypnotherapeutic context while simultaneously...

Cell-type-specific eQTLs underlie the genetic architecture of complex traits

Genetic effects on complex traits primarily act by regulating gene expression; however, this process is not well understood1. Studies of genetic effects on gene expression (expression quantitative trait loci (eQTLs)) can inform as to the gene regulatory layer between genetic vari...

Clinical Application of the Perspective Shift Technique in Persistent Grief: From Grief Care to Grief Therapy

Grief has long been understood primarily as a domain of care rather than therapy: a naturalresponse to loss that unfolds over time, with the supporter’s role being to accompany theprocess rather than to intervene in it. The Continuing Bonds framework (Klass, Silverman,& Nickman,...

Dual dimensions of productivity in cross-community mathematics teacher dialogue

Abstract While scholars have been calling for cross-community teacher dialogue, it remains relatively rare, both in research and in practice, and its potential productivity is unclear. We propose a dual framework distinguishing between pedagogical productivity and boundary produc...

The Three-Layer Rational Consciousness Zone Theory: A Clinical Framework for the Consciousness Conditions of Memory Reconsolidation in Hypnotherapy and Psychotherapy

This paper introduces the Three-Layer Rational Consciousness Zone Theory (TLRCZT) — a novel theoretical framework that defines the consciousness conditions under which memory reconsolidation most reliably occurs in clinical practice. While memory reconsolidation research has esta...

Public perceptions of polygenic testing and embryo selection for non-medical traits

Abstract Some advances in reproductive technologies raise substantial ethical and psychological challenges, for example, the use of preimplantation genetic testing to select embryos based on non-medical traits. While studies have explored public willingness to use preimplantation...

Bethe Ansatz with a Large Language Model

We explore the capability of a Large Language Model (LLM) to perform specific computations in mathematical physics: the task is to compute the coordinate Bethe Ansatz solution of selected integrable spin chain models. We select three integrable Hamiltonians for which the solution...