Research works

Large-scale array of squeezed light and synchronization using atomic vapor

Abstract Quantum light sources such as squeezed light are essential for quantum information science and technologies, but the scalable production of multiple beams of them remains a challenge. Here, we experimentally demonstrate a novel approach to the generation of a large spati...

HO-1 Nuclear Interactome Implications in Neuroendocrine Transdifferentiation in Prostate Cancer

Neuroendocrine prostate cancer (NEPC) is characterized by androgen receptor (AR) independence and poor response to conventional therapies, highlighting the need to unveil the molecular mechanisms behind NEPC. We previously showed that heme oxygenase 1 (HO-1, encoded by HMOX1) tra...

Dashboard to support emergency department management

Emergency departments are complex, high-pressure settings that must deliver rapid, accurate and safe care to patients with widely varying levels of acuity, often under severe resource constraints. Dashboards have been proposed as decision-support tools to mitigate overcrowding an...

Engineering a terephthalate-responsive PobR biosensor for discovering PET-degrading microbes via cell-to-cell communication

Abstract Background Poly(ethylene terephthalate) (PET) is one of the most widely used synthetic plastics, yet its environmental accumulation continues to outpace effective recycling. Although PET-degrading enzymes and microorganisms have been reported, discovery of new PET-degrad...

Molecular overview of major salivary gland carcinomas in chilean patients: 2 case reports

Abstract Background Salivary gland tumors (SGTs) are rare neoplasms that account for 8.5 % of head and neck cancers and comprise a highly heterogeneous group of benign and malignant subtypes, according to the World Health Organization. In Chile, epidemiological and molecular data...

Seder Cognitivo And The Universe Of Instants: Why The Asymmetry Of Memory Is Not A Physical Problem But A Problem Of The Mind

This preprint introduces the concept of Cognitive Seder (from Hebrew seder, meaning order) as an active principle of the mind that scans and organizes static instants (Nows) into meaningful temporal sequences. Building on Julian Barbour's timeless universe of configurations, the...

EditQL: A query language for evolving models

Abstract Context: Technically sophisticated systems are the result of the joint work of several domain experts. However, the more people collaborate, the more important it becomes to make the model evolution and its single edit operations accessible and comprehensible for involve...

Metabolic control of smooth muscle cell phenotype switching in atherosclerosis

Abstract The loss of smooth muscle cell (SMC) contractile phenotype contributes to various diseases including atherosclerosis. However, its metabolic basis is not entirely elucidated. Since the transforming growth factor beta (TGFβ) signaling is among principal regulators of SMC...

Spontaneous segmentation of slow slip events on a homogeneous planar fault

Abstract Slow slip events (SSEs) are transient aseismic fault slip events that often display segmentation along strike. While fault segmentation is commonly attributed to physical heterogeneities, numerical studies have shown that segmentation can also occur on homogeneous planar...

Prefoldin function links meiotic chromosome segregation with cellular remodeling and reveals tubulin sensitivity of the meiotic spindle

Abstract Faithful chromosome segregation is essential for producing viable gametes during meiosis, a specialized type of cell division compared to mitosis. Unlike mitosis, meiosis involves two consecutive chromosome segregation events without an intervening round of DNA replicati...

A sustainability index for strategic mine planning: integrating closure and environmental costs into phase prioritization

Abstract This paper proposes a phase-based evaluation workflow for strategic mine planning in which environmental and closure costs associated with each project phase are quantified after a base-case block sequencing and then compared with the economic performance of the resultin...

A Scoping Review of Virtual Reality in Blue Space Research

This study aims to systematically review the current applications and development trends of virtual reality (VR) technology in blue space research. It clarifies the main research methods, technical pathways, application scenarios, and existing knowledge gaps, and integrates the a...

Parental niche construction buffers microbial and competitive challenges and drives offspring dependence in burying beetles

Parents across diverse taxa modify the biotic or abiotic environments of their offspring. Such modifications may constitute ecological inheritance and are central to developmental niche construction, whereby organisms shape developmental conditions and selective pressures experie...

An efficient cross-chain interaction mechanism for large-scale multichain environments

Abstract To address the scheduling difficulties, high verification overhead, and insufficient transaction processing efficiency encountered in cross-chain interactions under high-concurrency scenarios, an efficient cross-chain interaction mechanism is proposed. First, a cross-cha...

Data-driven styling optimization of an intelligent medical waste recycling robot using AHP-CRITIC and SSA-ELM

Abstract To improve the attractiveness and practicality of intelligent medical waste recycling robots, this study proposes a data-driven styling optimization framework integrating Kansei Engineering, AHP-CRITIC weighting, and a Sparrow Search Algorithm-optimized Extreme Learning...

Crimean-Congo hemorrhagic fever virus protein GP38 from isolate M18-China confers broad immunological breadth

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne, negative-strand RNA virus that causes outbreaks of lethal hemorrhagic fever. No approved vaccines or specific antiviral treatments are available. CCHFV glycoprotein GP38 is an integral component of the pre-fusion glyc...

Expert Consensus Develops Multidisciplinary Pathway for Cancer Pain Management in Italy: A Delphi Study

Background: Cancer pain remains highly prevalent and undertreated despite established guidelines. In Italy, Law 38/2010 mandates systematic pain assessment, yet only 26% of clinicians routinely evaluate pain at each clinical visit, and fewer than one-quarter have received formal...

A Systematic Transparency Assessment Framework for Life Cycle Background Database to Address Three-Level Black Boxes

Life cycle background database (LCBD) is central to carbon footprint and life cycle assessment (LCA) modeling, yet transparency remains inconsistent across mainstream (ecoinvent, GaBi, USLCI) and emerging (TianGong, HiQLCD) databases. A lack of unified disclosure standards result...

POLIS V13: A Universal Tensional Conservation Theory – Unification of Matter, Energy, Information, Gravity, Light, Life, Consciousness and Cosmology

POLIS V13 is the complete formulation of the tensional conservation framework, generalising V12 while preserving all its empirical validations. The theory replaces fixed physical analogies (solid, liquid, gaseous) with neutral tensional layers identified solely by their normalise...

Mercury–carbon relationships in environmental media near artisanal gold mining sites in Guyana

Elevated atmospheric mercury (Hg) concentrations from artisanal gold mining increase Hg exposure in adjacent forest canopies. Although pools and fluxes of Hg and carbon (C) within environmental media are connected, it is unclear how these Hg/C patterns may differ between areas ex...