Research works

Double Trouble: How Unresolved Spectroscopic Binary Stars Skew GALAH DR4 Stellar Parameters

Abstract Unresolved binary stars introduce systematic biases in stellar parameter estimates when analysed assuming a single star. Using ~917,000 spectra from the Galactic Archaeology with HERMES (GALAH) Data Release 4 (DR4), we develop a binary spectral model that fits each obser...

Establishing the role of ZBTB20 mutations in GnRH deficiency and impaired neurogenesis in the subventricular zone: a human cohort and animal model study

Background Congenital hypogonadotropic hypogonadism (CHH) arises from defective development or dysfunction of GnRH neurons. Olfactory bulb (OB) malformations frequently accompany CHH, a condition termed Kallmann syndrome (KS). Nevertheless, approximately 50% of CHH cases remain g...

Performance evaluation of GPS and BeiDou hybrid positioning using a low cost GNSS receiver in Nigeria

This study evaluates the performance of Global Positioning System (GPS)-only, BeiDou-only, and hybridized GPS+BeiDou Global Navigation Satellite System (GNSS) constellations in Nigeria, with emphasis on positional stability and the benefits of multi-constellation integration. A d...

Combined administration of fructooligosaccharides and Clostridium butyricum attenuates bowel cleansing-induced dysbiosis and safeguards mucosal defense in a murine model

Bowel preparation with polyethylene glycol electrolyte solution (PEG-ELS) is indispensable for gastrointestinal endoscopy and related procedures. However, it disrupts gut microbial homeostasis and increases host vulnerability to ensuing infection. In a murine model, we optimized...

Integrating Kidney Imaging for Risk Prediction, Therapeutic Monitoring, and Prognostication Across the Kidney Disease Spectrum: A Review of Emerging Evidence

Abstract Kidney imaging advances are transforming the field of nephrology by allowing non-invasive examination of renal structure, function, and pathology. Traditional measures such as albuminuria and estimated glomerular filtration rate (eGFR) are only partially effective in ide...

The Polymorphic Queen: L-Forms, Bacterial Pleomorphism, and the Underground Medical School

This monographic essay executes a radical forensic and experimental deconstruction of Robert Koch's dogma of linear monomorphism, exposing the greatest logical and technological flaw of institutional microbiology: the methodological deception of the microfilter. Contemporary medi...

Abandoning democracy for the nation

In an era defined by the paradoxical coexistence of popular support for democracy and the practical erosion of its core tenets, Filip Milacic’s Abandoning Democracy for the Nation. arrives as a tim...

Stanislao Cannizzaro: Chimica e rivoluzione

Oliviero Carugo’s book introduces Stanislao Cannizzaro to a broad readership by placing his career within the overlapping histories of chemical research, science teaching, Risorgimento politics, an...

AI-Driven Healthcare Transformation: An Empirical Study of Clinical Innovation, Operational Efficiency, and Patient Outcomes

Objectives: The rapid advancement of artificial intelligence (AI) is transforming healthcare delivery by enabling data-driven clinical decision-making, intelligent automation, predictive analytics, personalised care, and improved resource utilisation. However, the organisational...

In defense of the moral agency principle: abilities, reasons, and the puzzle of collective duties

Abstract The Puzzle of Collective Duties concerns a tension between the moral requirements of non-agential groups and two important principles of ethical theory, namely Ought Implies Can and the Moral Agency Principle. According to the Moral Agency Principle, if A has a moral dut...

High-Efficiency Direct AC LED Driver with Adaptive Constant-Power Architecture

This paper presents a high-efficiency direct-AC LED driver integrating a 14-stage voltage-segmented architecture, digitally coordinated stage selection, and adaptive current-reference regulation. The proposed driver provides finer matching between the rectified bus voltage and th...

A Blockchain-Based Tokenize–Track–Trace (3T) Architecture for Oracle-Anchored Supply Chain Traceability Using Dynamic NFTs and Smart Contracts

This paper introduces an approach based on blockchain and dynamic Non-Fungible Tokens (dNFTs) for transparent supply chain management (SCM) through end-to-end traceability and automation. The approach addresses three recurring limitations of blockchain-enabled SCM: physical-to-di...

Protein-Containing Breakfasts Are Associated with Reduced Postprandial Glycaemic Excursions in Children and Young People with Type 1 Diabetes: A Pragmatic Study

Background/Objectives: This study examined whether adding 10 g of protein to a high glycaemic index (GI) breakfast could attenuate postprandial glycaemic responses in children and young people (CYP) with type 1 diabetes (T1D). Postprandial glucose responses following this modifie...

Novel Antibodies for Managing Cachexia

Cachexia is a complex, multifactorial syndrome driven by anorexia and systemic inflammation, ultimately resulting in a catabolic state characterized by weight loss, decreased muscle mass, and impaired physical function. Many chronic comorbidities are implicated in the pathophysio...

Hypoxia induces microtubule rearrangement in intestinal epithelial cells

Microtubules are integral components of the highly regulated and dynamic cytoskeleton which is vital for cell function and the maintenance of homeostasis. Microtubule disruption is associated with multiple disease states including colorectal cancer and neurodegenerative disorders...

The Challenge of Adapting a Spatial Accessibility Indicator Developed for Primary Care to the Hemodialysis Context

Background: Access to dialysis facilities greatly affects patients' quality of life and healthcare costs. Transportation alone represents 21% of dialysis-related expenses. Going beyond a simple focus on access, this study aimed to evaluate dialysis care accessibility in France by...

Erdős–Straus Project Archive: Residual Divisor Shells, Quotient Surpluses, and Finite Verification

This release consolidates the Erdős–Straus project under its existing concept DOI. The principal paper develops the residual divisor-shell equivalence and its origin counts, proves the Star–Kneser quotient-surplus theorem, and records the exact certificate at p = 12289 with R = 1...

Towards a Digital Twin infrastructure for landslides: users and data requirements

Abstract. The increasing frequency and magnitude of landslides necessitates a fundamental shift from reactive mitigation to proactive, predictive risk governance. To define the necessary tools for this transition, this study conducts a systematic literature review and operational...

"I want to see something different": The Middlebrow Diary Novel and Elizabeth von Arnim's In the Mountains

Abstract: This article reads Elizabeth von Arnim's In the Mountains (1920) as one of the first middlebrow diary novels, an intimate and comedic genre that has received little scholarly attention. I argue that In the Mountains provides an alternative to the modernist postwar lamen...

General Projection Geometry Draft (III): The Major Discovery of 0=1 — From Deng Yu's Mathematical Derivation to Vacuum Ontology

The core hypothesis of General Projection Geometry — "0 = 1, and 1 is in 0" — is grounded in a deep reading of Deng, Hani, and Ma's rigorous derivation from hard-sphere dynamics to the Boltzmann and fluid equations (Hilbert's Sixth Problem). Microscopic reversibility harbors late...