Research works

Deciphering Transcriptional Dynamics of Angelica sinensis Seed Development to Define the Optimal Harvesting Stage

The root of Angelica sinensis (Oliv.) Diels is a traditional Chinese medicine. While physiological and biochemical approaches to improve seed quality during maturation have been explored, the regulatory mechanism governing the optimal harvesting stage remains uncovered. Here, tra...

Self-buoyant cell-spheroid culture programming multi-spheroid assembly

Tempo-spatially controlled culture and assembly of cellular spheroids are fundamental in engineering tissue-like assembloids for scalable application, yet remain a technical challenge. Here, we show self-buoyant culture of cell spheroids and programmable assembly of multi-spheroi...

Myeloid cell reprogramming drives enhanced defense against Streptococcus pneumoniae lung infection following exposure to commensal Prevotella

Clinical data link the prevalent respiratory tract anaerobe Prevotella with reduced pneumonia mortality, but the mechanisms directing Prevotella regulation of lung immune homeostasis are unclear. Here, single-cell RNA sequencing was employed to define the transcriptional immune s...

DLP Bioprinting of Bilayer Recombinant Collagen Scaffolds for Immunoangiogenic Microenvironment Remodeling and Diabetic Wound Regeneration

Abstract Chronic diabetic wounds remain difficult to heal because of persistent oxidative stress, chronic inflammation, impaired angiogenesis, and dysfunctional extracellular matrix remodeling. Developing biofabricated living scaffolds that combine structural support with active...

Turning the tables: Repurposing neuroplasticity to defeat cancer

Instead of asking what nerves do to cancer, my work reveals how cancer injures and reprograms peripheral nerves to drive immune evasion and how targeting this process restores immunotherapy responses.

Targeted fine-tuning of machine-learning interatomic potentials for phonons and phase transitions

Abstract Machine-learning interatomic potentials are widely used as computationally efficient surrogates for density functional theory in atomistic simulations, enabling large-scale and long-time modeling of materials systems. Here, we investigate how different fine-tuning strate...

Peptide-Reduced Platinum-Based Nanozymes for Wound Treatment of Methicillin-Resistant Staphylococcus aureus Infection

Abstract Methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds remain difficult to treat because of antibiotic resistance, biofilm formation, and persistent inflammation, highlighting the need for alternative local antibacterial strategies. Herein, we developed a pla...

CiPLDδ2 determines postharvest storage stability of pecan by regulating membrane lipid degradation and the antioxidant system

The high oil content, combined with unsaturation, of pecan ( Carya illinoinensis ) kernels renders them prone to oxidation as well as hydrolysis during storage, thereby causing quality deterioration. Previous evidence indicates that Phospholipase D δ2 in C. illinoinensis ( CiPLDδ...

Small Extracellular Vesicle-Associated Chromosome 14 microRNA Cluster Members Reveal Distinct Molecular Responses to E-Liquid Exposure in Human Lung Cells

Background/Objectives: The adoption of electronic cigarettes and vaping devices worldwide as healthier alternatives to smoking tobacco has led to a new clinical condition termed EVALI—E-cigarette or vaping-associated lung injury. The symptoms of EVALI present large overlaps with...

Macrophage pyroptosis drives luminal senescence and club-cell reprogramming in 5α-reductase inhibitor-treated prostatic hyperplasia

Abstract Benign prostatic hyperplasia (BPH) is a common age-associated disease whose prevalence rises sharply with advancing age. Therapeutic responses to 5α-reductase inhibitors (5-ARIs) in BPH are heterogeneous and may ultimately culminate in the need for surgery; however, the...

Innovative pedagogies for responsible management education: advancing the i5 framework and UKPSF across PRME business schools in the UK and Kazakhstan

Purpose This study investigates how the integration of the UN Principles for Responsible Management Education (PRME) Impactful Five (i5) framework and the UK Professional Standards Framework (UKPSF) can advance responsible management education in higher education. Drawing on PRME...

Comparative Efficacy of Electrical Stimulation Therapies for Bone Healing

Objective: This network meta-analysis aimed to evaluate the effectiveness of electrical stimulation (ES) in promoting bone healing and to identify the optimal modality. Design: This network meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analy...

Mitigating urban tunneling risks: Detecting adverse geology with a tunnel-surface-borehole observation system using TBM drilling noise source

Accurately forecasting adverse geological conditions ahead of the tunnel face is a critical challenge for the safety and efficiency of mechanized urban tunneling. Unforeseen features such as faults and karst cavities often pose significant geohazards, including collapse, ground d...

The selective IGF-1 fusion protein scp776 targets apoptotic cells and promotes recovery of ischemia/reperfusion injured tissues: Engineering and preclinical validation

Acute myocardial infarction (AMI) and acute ischemic stroke (AIS) continue to be substantial burdens on global health, despite recent advances in care. Current treatment strategies focus on blockage removal and establishment of reperfusion, but there are no approved treatments to...

DMC-YOLO: An improved YOLOv12-based approach for ship detection in distributed acoustic sensing images

Ship detection plays a vital role in ensuring maritime transportation and navigation safety. However, achieving accurate and efficient detection in distributed acoustic sensing (DAS) images remains challenging due to unique linear texture features, complex hydroacoustic backgroun...

Unified Analytical Model for Circular Confined Concrete Stub Columns with Solid, Hollow, and Double-Skin Tubular Column Sections under Axial Compression

Abstract The design of circular concrete columns confined by steel or fiber-reinforced polymer (FRP) tubes critically depends on the accurate estimation of the stress state within both the concrete core and the confining materials (steel and FRP). A precise understanding of these...

KSHV K15 genetic heterogeneity is associated with Kaposi sarcoma aggressiveness through modulation of the host inflammatory microenvironment

Kaposi sarcoma (KS) exhibits profound clinical heterogeneity, yet current risk assessment remains constrained by anatomical staging systems that lack universality across diverse KS variants. This study characterized the functional impact of Kaposi’s sarcoma-associated herpesvirus...

Areths and the Provisional Polythetic Areth Classification System (PPACS): a hierarchical and nomenclatural framework for Martian soil classification

The absence of a formally defined and operationally robust classification system for Martian soil material represents a critical gap in planetary science. While substantial compositional and remote sensing data exists, these datasets have not yet been integrated into a coherent,...

Supply Chain Management Capabilities and Organizational Sustainability in Universities: Pandemic Preparedness Mixed Methods Evidence

Background The coronavirus disease (COVID-19) pandemic demonstrates the importance of organizational sustainability across all sectors, and universities are no exception. It revealed deep-seated fragilities in institutional supply chains, revealing that the ability to sustain cor...

CoRSEER: the calculator of rock surface exposure age and erosion rates for luminescence rock surface exposure dating

Luminescence rock surface exposure dating (LRSED) estimates the duration of rock surface exposure and the rate of erosion by analysing changes in luminescence with depth below the surface. The wider use of this method has been slowed by limitations in mathematical analysis, such...