Research works

Clonal lineage tracing and parallel multiomics profiling reveal transcriptional heterogeneity induced by ARID1A deficiency

Transcriptional heterogeneity drives malignant progression, yet how it emerges within tumors remains unclear. By combining genetic perturbation and lineage tracing with parallel single-cell multiomics, we tracked the consequences of ARID1A loss within individual clonal lineages....

Multivariate analysis identifies distinct latent components and highlights the contribution of motor cortex neurochemistry to clinical variance in amyotrophic lateral sclerosis

Abstract Amyotrophic lateral sclerosis (ALS) is marked by substantial clinical heterogeneity across motor and extramotor domains, yet how different neuroimaging modalities jointly relate to this heterogeneity remains poorly understood. Prior ALS neuroimaging studies have largely...

Twelve-Hour Dynamic Monitoring of Microalgae Response to Oxidative Stress by Single-Cell Metabolomics Analysis

Abstract Cellular metabolism is inherently dynamic during stress responses, yet conventional single-cell metabolomics workflows remain largely limited to isolated snapshots. Here, we implemented an online, label-free CyESI-MS-based workflow for the continuous monitoring of single...

Interval type-3 fuzzy control with optimized active tuned mass dampers for seismic response reduction in high-rise buildings

This study proposes an Interval Type-3 Fuzzy Logic Controller (IT3-FLC) integrated with an Active Tuned Mass Damper (ATMD) for seismic vibration mitigation in an eleven-story high-rise building. The building–ATMD system is formulated in state-space form, while the fuzzy-controlle...

Lean tool selection in the context of Industry 4.0: a hybrid Pythagorean fuzzy multi-criteria decision-making method

Purpose Lean 4.0 tools have been developed by integrating digital technologies with lean philosophy to support autonomous process improvement. This development addresses the limitations of traditional lean tools, which rely on manual observation and human effort and may be insuff...

Multimodal deep learning architecture for gym exercise recognition and real-time posture error detection using LSTM and RAG-based expert chatbot

The growing popularity of home fitness has led to an increase in home-based fitness training. Still, the lack of supervision by a trained professional has resulted in improper form, thereby increasing the risk of injury during exercise. Automated computer vision systems have also...

Diagnoses associated with reimbursement of cannabis for medical purposes among Canadian Veterans, 2016-23

Introduction : Canadian Veterans who are authorized to access cannabis for medical purposes (CMP) by a health care practitioner may be reimbursed for the cost by Veterans Affairs Canada (VAC). To assess eligibility for reimbursement, VAC receives and reviews medical authorization...

Perceived Time Availability for Self-Care and Quality of Life in Patients with Major Depressive Disorder: A Cross-Sectional Study in Ho Chi Minh City, Vietnam

Background: Major depressive disorder (MDD) severely impairs quality of life (QoL), yet contextual constraints such as perceived time availability for self-care remain underexplored in low- and middle-income countries. This study evaluated multidimensional QoL and identified its...

Herpes simplex virus type 2 induces S-phase entry and arrest to regulate the cell cycle for efficient replication

Viruses often hijack core host cell processes to optimize their replication. In the current study, we conducted comparative proteomics analyses of epithelial cells infected by the prevalent human pathogen herpes simplex virus type 2 (HSV-2), followed by experimental validation. T...

Introduction of a digital care companion to facilitate patient reported outcome measures and breast care nurse-led survivorship

As part of the Breast Cancer Survivorship program in the Royal Melbourne Hospital (RMH), a new electronic platform, Care Companion was designed to facilitate resource access, appointments and monitoring of breast cancer patients using patient-reported outcome measures (PROMs). Th...

Optimizing pre-listening activities with AI-assisted priming for L2 listening comprehension

As second language (L2) listening presents significant real-time processing challenges for less competent L2 learners, pre-listening activities provide them with the much-needed mental scaffolding. Recent research has suggested that augmenting top-down predictive processing could...

Multilevel Resource Capacity and Inequality in Community Eldercare Access Among Older Adults in China: Household Living Arrangements as Conditional Contexts

Background/Objectives: Access to community eldercare reflects the joint distribution of economic resources, social protection, local infrastructure, and household circumstances. Drawing on the capability approach, this study examined whether multilevel resource capacity was assoc...

Repurposing Antibody-Drug Conjugates for Theranostic Targeting of Nectin-4 and TROP2 in Bladder Cancer

Abstract The application of antibody-drug conjugate (ADC) therapies in advanced bladder cancers may be improved through non-invasive molecular imaging and therapy with targeted radiation. Enfortumab and Sacituzumab, the antibody components for the ADCs PADCEV (Nectin-4 targeting)...

Dual-docking robotic total proctocolectomy for familial adenomatous polyposis with synchronous rectal and sigmoid carcinomas: a methodology of port placement and docking strategy

Abstract Dual-docking robotic total proctocolectomy (TPC) for familial adenomatous polyposis (FAP) with synchronous carcinomas presents technical challenges in port placement, and a detailed methodology is currently lacking. This article reports a case of dual-docking robotic TPC...

Provenance and competence for CHIKV and DENV of Aedes albopictus populations

Aedes albopictus is one of the world’s most hazardous invasive species, increasingly implicated in the autochthonous transmission of Chikungunya (CHIKV) and Dengue (DENV) viruses in newly colonized areas. Since invading the Mediterranean Basin several in the early 1980s, recurren...

Contrasting macro- and meso-litter accumulation in managed and unmanaged beach sectors of the northwestern Adriatic Sea

Abstract Beach management practices are widely implemented in coastal environments, yet their association with litter size structure remains poorly understood. We evaluated macro- and meso-litter across vegetated (unmanaged) and non-vegetated (managed) beach areas along the north...

Electrically Programmable Polarization‐Resolved Photodetector Platform for Filterless Computational Spectroscopy and Imaging

ABSTRACT Conventional spectrometers and polarization‐resolved imagers rely on dispersive optics or filter stacks, significantly limiting their miniaturization and system integration. Herein, a compact perovskite/organic blazed‐grating photodetector that functions as a bias‐encode...

Early Life Adversity and Prosocial Behavior in Adolescence: The Mediating Role of Childhood Empathy

ABSTRACT Introduction Extensive evidence demonstrates that early life adversity (ELA) has enduring contributions to psychological and physical problems, yet little research has examined how ELA may potentially influence positive adaptation. In this longitudinal, multi‐method stud...

Metal nanoparticles incorporated MIL-101(Cr) for enhanced hydrogen storage at room temperature

MIL-101(Cr) is considered a potential material for hydrogen (H 2 ) storage, but its H 2 uptake at room temperature was found to be low. However, incorporating metal nanoparticles (MNPs) into the framework helps enhance its H 2 uptake. Platinum (Pt) is the commonly used MNP to inc...

Engineering antifouling UiO-66-NH₂ mixed matrix membranes for geothermal brine pretreatment: Fouling prediction, techno-economic analysis, and environmental assessment

This study develops polysulfone/UiO-66-NH₂ mixed-matrix membranes (MMMs) for silica removal from geothermal brine and evaluates their antifouling behavior, fouling mechanisms, techno-economic feasibility, and environmental implications. Incorporation of UiO-66-NH₂ improved membra...