Research works

Data-Driven Digital Twin for Amylosucrase from Deinococcus geothermalis : Accelerating Acceptor Discoveryin Transglycosylation Reactions

Abstract Enzymatic transglycosylation by Deinococcus geothermalis amylosucrase (DgAS) offers a cost-effective route for enhancing the physicochemical properties of bioactive flavonoids. However, predicting DgAS acceptor specificity remains challenging due to complex structure–act...

From Disclosure Controls to Statutory Enforcement: Regulating Corporate Greenwashing through Forensic Accounting and a Comparative Analysis of HK SFC and UK FCA Regimes

As corporate sustainability disclosures transition from voluntary reporting to statutory mandates, corporate greenwashing presents a structural threat to financial market integrity and sustainable capital allocation. Utilizing a desk-based qualitative framework combining doctrina...

Endoscopic versus catheter-based minimally invasive evacuation of spontaneous supratentorial intracerebral hemorrhage: a systematic review and meta-analysis

Abstract Minimally invasive surgery (MIS) for spontaneous supratentorial intracerebral hemorrhage (sICH) includes endoscopic evacuation and catheter-based evacuation (aspiration or drainage ± thrombolysis), but comparative performance remains uncertain. We performed a systematic...

Mental Health Disorders, Suicide Attempts, Substance Use, and Substance Use Disorders in Adults with Fetal Alcohol Spectrum Disorders: A Gender-Separated Study

Abstract Fetal alcohol spectrum disorders (FASD) are a group of neurodevelopmental disorders caused by alcohol exposure during pregnancy. FASD is associated with various neurocognitive disorders over the entire lifespan. Comorbid mental health disorders seem to be highly prevalen...

Single-session therapeutic plasma exchange as salvage therapy for pegaspargase-induced severe acute pancreatitis accompanied by multiple organ dysfunction in a pediatric patient with B-cell precursor acute lymphoblastic leukemia: a case report

Abstract Background Pegaspargase-related severe acute pancreatitis (SAP) combined with persistent multiple organ dysfunction syndrome (MODS) is a life-threatening adverse reaction in children receiving acute lymphoblastic leukemia (ALL) chemotherapy. Standard intensive supportive...

Cross-Sector Pattern from Two Constants: Eight Standard-Model Observables Constrained by p and q

We report an empirical pattern in which eight Standard Model observables—the Higgs mass, the top-quark mass, three PMNS mixing angles, two CP-violating phases, and the strong coupling constant—are constrained to within ±1% by two constants, p≈0.5437 and q=1/5, with zero adjustabl...

p38β-mediated BiP phosphorylation drives stemness and chemoresistance by suppressing UPR activation in hepatocellular carcinoma

Abstract Tumor-initiating cells (TICs) promote tumor initiation and therapy resistance, yet the kinase regulators that sustain TICs remain incompletely defined. Here, we identify the stress kinase p38β (MAPK11) supports TIC maintenance and drug resistance in hepatocellular carcin...

Integrative multiomic analysis identifies transcription factors and target proteins in renal cell carcinoma

Abstract Renal cell carcinoma risk is partly shaped by germline genetic variants that often reside in regulatory regions. However, the transcription factors (TFs) and downstream proteins via which they shape RCC susceptibility remain incompletely characterized. Here we show that...

Design, Synthesis,and Evaluation of Alkoxyamine AnticancerProdrugs Bearing Galactoside as an Enzyme-Activated Trigger

Abstract Enzyme-induced cytotoxicity can be considered the main challenge in modern cancer therapy that provides unique opportunities for targeted apoptosis. To address this challenge, we implemented enzyme-triggered activation of alkoxyamine–galactose conjugates with the formati...

Associations of beans, bean products, and soy isoflavone intake with chronic kidney disease: a cross-sectional study

Abstract Background Current evidence on the association between beans and bean products intake and chronic kidney disease (CKD) remains limited. In vitro and animal studies suggest that soy isoflavones exhibit antioxidant and anti-inflammatory properties, potentially conferring r...

DECIDER-2: Prospective randomized multicenter phase III trial of decitabine and venetoclax administered in combination with all-trans retinoic acid or placebo in patients with acute myeloid leukemia who are ineligible for induction chemotherapy

Abstract Background Acute myeloid leukemia (AML) is predominantly a disease of older patients with a poor long-term survival. Approval of the combination of venetoclax (VEN) with azacitidine (AZA) or decitabine (DAC) in the European Union in 2021 for the treatment of patients wit...

“I Wasn’t Alone in How I Am”: Psychological Inquiry Into Players’ Experiences With Queer Representation in Gone Home

While there has been an explosion of research around the psychological dynamics of video game play, comparatively little work has been to explore the many divergent approaches video games take to create identification and connection within it’s players, especially around LGBTQ+ r...

Finite Partition-Function Curvatures

Let $Z(\beta)=\sum_{j=1}^{m}g_j e^{-\beta e_j},\qquad$ $0<g_j,\quad e_1<\cdots<e_m,$ be a primitive finite weighted canonical partition function, and let \(K=(\log Z)''\) be its log-partition curvature. Physically, \(K\) is the canonical energy variance and satisfies \(C_V=k_B\be...

Assessing acuity in pediatric emergency department triage: performance of a large language model

Pediatric triage performance varies across emergency departments (ED), contributing to ongoing challenges in pediatric emergency care. There is growing interest in using large language models (LLMs) to support more consistent triage decision-making in children. We evaluated an LL...

The Role ofPolyQ in Global Conformational Dynamicsand Stability of Huntingtin

Abstract Huntington’s disease (HD) is known for its abnormal polyQ stretch in the first exon of the HTT gene. HD is listed among the fatal autosomal dominant neurodegenerative disorders targeting the central nervous system and interfering with motor, cognitive, and psychiatric fu...

Macrophage-to-myofibroblast transition-derived itaconate promotes bone metastasis in lung cancer through targeting of HSPA8

Abstract Lung cancer bone metastasis carries a poor prognosis, yet the metabolic determinants driving tumour–stroma crosstalk remain largely elusive. Despite extensive investigations into itaconate, a prominent immunometabolite implicated in macrophage polarization, the precise m...

The Garden That Left No Trace: Virtual Reconstruction at the Evidential Minimum — a Conjectural Renaissance Kitchen Garden for Burg Schönebeck

Gardens are the most perishable class of built heritage. A demolished building leaves foundations, fragments, andusually documents; a garden leaves soil. When the garden in question was a working kitchen garden at a minorWestphalian castle — never painted, never engraved, never d...

Extracellular Matrix-InspiredElectrospun Nanofiber-Coated3D-Printed Polylactic Acid Scaffolds for Bone Regeneration

Abstract Three dimensional (3D)-printed polylactic acid (PLA) scaffolds have gained significant attention for bone tissue regeneration due to their excellent biocompatibility, tunable architecture, and mechanical strength. However, the hydrophobic and bioinert surface of PLA limi...

Auricular Neurostimulation: A Novel Therapy for Abdominal Pain-Related Disorders of Gut-Brain Interaction

Disorders of gut-brain interaction (DGBI) are highly prevalent in the pediatric population. DGBI are heterogeneous disorders with presumed multifactorial pathophysiology. Emerging studies document autonomic nervous system alterations in at least a subset. There is significant sym...

Weight status, percent body fat, eating habits, depression, and food addiction in Palestinian university students: a cross-sectional study

Abstract Background Obesity and excess adiposity among university students are important public health concerns. This study aimed to determine the prevalence of overweight and obesity among Al-Quds University students using both body mass index (BMI) and percent body fat (PBF), a...