Research works

Therapeutic NAMPT inhibition reveals a targetable metabolic vulnerability in neuroblastoma

Abstract Background Neuroblastoma (NB) remains a major cause of pediatric cancer mortality for which new therapeutic strategies are needed. Exploitation of reprogrammed metabolic pathways offers an opportunity for cell-type specific anticancer therapeutics. To identify pediatric...

Accelerating ML-based super-resolution for gigapixel-scale acoustic imaging

Abstract Gigapixel-scale acoustic imaging is increasingly used in biology, materials science or industrial failure-analysis to capture fine structural details across large fields of view (FOV). Automated analysis is essential for interpreting these datasets, yet a large pixel-cou...

Integrating Petri net heuristics within MILP for optimizing energy-efficient scheduling of flexible manufacturing systems

Abstract Flexible Manufacturing Systems (FMSs) increasingly need to reconcile flexibility, high productivity and energy efficiency. This paper addresses the energy-efficient scheduling of routing-flexible FMSs with multiple job instances, shared machines and route-level Work-in-P...

From Disclosure Controls to Statutory Enforcement: Regulating Corporate Greenwashing through Forensic Accounting and a Comparative Analysis of HK SFC and UK FCA Regimes

As corporate sustainability disclosures transition from voluntary reporting to statutory mandates, corporate greenwashing presents a structural threat to financial market integrity and sustainable capital allocation. Utilizing a desk-based qualitative framework combining doctrina...

Labor Market Impact Disaggregation: Which Knowledge Work Tasks Are Actually Automated by LLMs

Research article: Labor Market Impact Disaggregation: Which Knowledge Work Tasks Are Actually Automated by LLMs

Ancient genomes of Sitka black-tailed deer show evidence for early postglacial dispersal along the Pacific Northwest Coast of North America

Abstract Background The Pacific Northwestern region of North America is inhabited by two distinct subspecies of black-tailed deer, Columbian ( Odocoileus hemionus columbianus ) and Sitka ( O. h. sitkensis ) black-tailed deer, which exhibit a complex evolutionary history shaped by...

Single-Chain Persistence Theory III: A Tool System for Explaining the Past, Diagnosing the Present, and Conditionally Predicting the Future

the series nomenclature goes live (three-tier architecture I/II/III, abolishing the old labels “narrow/broad/1.5”); implements the sole verdict ofVerification Gate No. 1 for the literature (the fid full-value resurrection in the mathematics chapter is re-marked as [Empirical]); v...

Genotype-dependent growth promotion by Kribbella and Nocardioides in maize under low-phosphorus conditions

Abstract Background and Aims Phosphorus (P) deficiency limits crop productivity. Root hairs are crucial for P acquisition and may influence plant–microbe interactions. We investigated how root-hair defects affect plant responsiveness to beneficial bacteria under low-P conditions,...

Minimal Non-Units, Prime-Support Boundaries, and Batch Unit Testing: A Structural Reformulation and Open Decision Problem for Deterministic Integer Factorization

This audit-corrected preprint consolidates research notes V0.2–V1.0 on deterministic integer factorization. It identifies the least prime factor of a composite integer as the first non-unit in natural order modulo N, separates prime-support information from evaluation circuit and...

Amphiphilic Lipid–PolymerTriblock Architecturesas Nanocarriers for Therapeutic Delivery

Abstract This study investigates the formation and characterization of nanocarriers derived from the self-assembly of amphiphilic lipid-polymer hybrids (LPHs) engineered with a symmetric ABA block copolymer architecture. In this design, the terminal A-blocks comprise branched hyd...

Chirality-Matched Cyclopropenimine–Thiourea Organocatalysis for Regiocontrolled Ring-Opening Polymerization of Methyl Glycolide

Abstract Poly(lactic-co-glycolic acid) (PLGA) is widely used in biomedical applications owing to its high biodegradability and biocompatibility. Although the ring-opening polymerization (ROP) of methyl glycolide (MeG) offers a route to synthesizing alternating PLGA, the comparabl...

Growth-promoting influence of selenium nanoparticles and ulvan derived from Ulva lactuca on the growth of maize during the seedling stage

Abstract Marine algae contain a vast array of bioactive molecules with diverse uses. One of their interests is to apply seaweed-derived nanoparticles or polysaccharides as bio-stimulants of seed germination for plant growth promotion. Two products derived from the green alga Ulva...

Contrasting eruptive dynamics and hazards of two Holocene andesitic sub-Plinian to Plinian eruptions, Lower and Upper Citlaltépetl, at Pico de Orizaba, Mexico

Abstract Pico de Orizaba (Citlaltépetl) stratovolcano, eastern Mexico, preserves a complex Holocene explosive record, yet the eruptive dynamics, source parameters, styles, and hazard implications of individual eruptive episodes remain poorly constrained. Here, we examine the 9600...

Digitalization to Intelligent Insurance: A Longitudinal Study of AI Transformation on Private General Insurance in India

The insurance industry is increasingly leveraging artificial intelligence (AI) to enhance operational efficiency, customer experience, and decision-making capabilities. While existing studies have predominantly focused on AI adoption determinants and specific application areas, l...

Spatiotemporal patterns of ambient NO2 and NO pollution in Kigali Rwanda

Abstract Kigali, like many cities in sub-Saharan Africa, faces rapid urban growth alongside the need to manage air pollution and protect public health. Despite its policy efforts, systematic data on nitrogen oxides (NO x : NO 2 and NO), key indicators of combustion-related pollut...

Galactose-FunctionalRAFT Agent for Biorelevant PolymericMaterials

Abstract In this work, we report a novel chain transfer agent (CTA) derived from d-galactose and evaluate its potential as a reversible addition–fragmentation chain-transfer (RAFT) agent. Using this galactose-based CTA, Gal-RAFT, both hydrophilic and hydrophobic monomers were suc...

Empirical evidence for a trade-off between reproduction and tumour dynamics in the freshwater cnidarian Hydra oligactis

Abstract Reproduction is a key life-history trait but often comes at the expense of somatic maintenance, including ageing and susceptibility to disease. While reproduction–immunity trade-offs have been experimentally demonstrated in the context of infectious diseases, whether rep...

Designing clinical AI for patient-centered support beyond the visit: the PACT framework for health systems

Clinical AI has advanced rapidly for bounded in-visit tasks such as prediction, documentation, and message generation, yet many costly failures in care occur outside the encounter when follow-up, handoffs, and communication break down. We argue that the next challenge for clinica...

Two new species of Diadiplosis (Diptera: Cecidomyiidae), predators of mealybug (Hemiptera: Pseudococcidae) from Brazil

Abstract Predatory cecidomyiids of the genus Diadiplosis Felt, 1911 (Diptera: Cecidomyiidae) are widely distributed throughout the Neotropical Region. Of the 34 species currently known in the genus, 14 have been recorded from Central and South America, making it, thus far, the ge...

Wireless Communication Evolution: A Comprehensive review of the Architecture, Technologies, Applications, Challenges, and Future Prospects of 6G

6G, the sixth generation of wireless communication, is expected to introduce exceptional technologies and use cases that once seemed fictional. Each generation of wireless communication systems has enabled the exchange of messages such as voice, video and other types of data betw...