Research works

Tirzepatide and the risk of atherosclerotic cardiovascular events: population based cohort study

Abstract Objective To estimate the magnitude of reduction in major adverse cardiovascular events (MACE) that would be observed in clinical practice from adding tirzepatide to standard of care treatment. Design Population based cohort study, using a design, data, and analytical ap...

Dissent enhances the credibility of groups of Bayesian conformist decision-makers

When making a decision, individuals use their private information to evaluate the available options. In a group, they can also learn from other group members' choices, which partially reveal their own private information. Bayesian estimation provides tools for modelling decisions...

Reimagining digital literacy and virtual identity in the Age of AI” - Special Collection Editorial

This special collection reflects on the need to reimagine teaching and learning spaces in the age of artificial intelligence (AI). Understanding digital literacy and virtual identity is essential to engaging with our contemporary society, which is defined by the fast pace of soci...

Decolonization vs Enhanced Cleaning for Multidrug-Resistant Organism Reduction in Nursing Homes

Importance Universal decolonization and enhanced cleaning are strategies to prevent multidrug-resistant organism (MDRO) transmission. Whether their associations with MDRO burden are overlapping, additive, or synergistic remains unknown. Objective To evaluate independent and combi...

The rise of carnivoran mammals in Europe through the lens of body mass

Carnivoran mammals (cats, dogs, bears, seals, etc.) and their kin radiated during the Palaeogene, among other carnivorous clades (hyaenodonts, mesonychians, and oxyaenodonts). This radiation has often been framed as a competition ultimately won by carnivorans, but the data suppor...

Extensive binding of poorly characterized human transcription factors to genomic dark matter

Abstract The functional impact of a large portion of the human genome known as “dark matter DNA”, which is composed mainly of repeat sequences, remains unknown. The genome also encodes many putative and poorly characterized transcription factors. Here, we determine genomic bindin...

An expanded codebook of human transcription factor DNA-binding specificity

Abstract Gene expression is regulated by transcription factors (TFs), which recognize specific DNA sequence motifs. Several hundred putative human TFs, identified mainly by an apparent DNA-binding domain, lack known binding motifs 1 . Furthermore, even for well-characterized TFs,...

Carrying Firearms and Suicide Risk Among Adolescents

Importance Firearms are the most lethal method of suicide across all ages, with case fatality rates exceeding 90%, warranting urgent public health concern. Understanding how carrying of firearms by adolescents and suicide risk vary by race and ethnicity and by stringency of state...

Accelerating biomass loss from forest disturbances across Europe

Abstract Forest disturbances are rising globally due to climate change and land-use pressures, weakening the terrestrial carbon sink. However, declines in aboveground biomass from tree cover loss remain poorly quantified, limiting our understanding of the role of disturbances in...

A dependency map enhanced with next-generation 3D cancer models

Despite advances in precision oncology, effective personalized treatments are still lacking for most patients with cancer1. The Cancer Dependency Map (DepMap) accelerates this field by systematically identifying cancer vulnerabilities in diverse preclinical models. Data from over...

Making sense of the extraordinary – An investigation of the content and prevalence of appraisals of nonordinary experiences

Individuals around the world report nonordinary experiences that stand out to them compared to their day-to-day or ordinary experiences. Yet, they can be appraised in very different ways, resulting in wellbeing and personal growth, or in marginalization and mental health problems...

A tumour-derived organoid biobank maps cancer gene dependencies

Abstract Cancer cell lines remain foundational for research and drug discovery, yet they incompletely capture tumour diversity, lack linked patient context, and have undergone adaptation to culture. Tumour organoids are three-dimensional cultures derived from patient tissue that...

A compendium of next-generation patient-derived models for diverse cancers

Abstract The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models 1,2 . However, existing collections represent only a fraction of the diversity observed in human cancer 2–4 . Recent technologies have enable...

Review of Particle Physics *

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,200 new measurements from 903 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and b...

Ontosystematics: Foundations of a Systematic Science of Ontological Nodes

Ontosystematics is the positive conceptual science of ontological nodes: their identity, composition, difference, inheritance, migration, transformation, and recombination across the habitats that host them. Its founding distinction separates a habitat — any historically occurrin...

Spatial surface gravity of small bodies from polyhedral shape models: slope, geopotential, and the resolution robustness of geopotential dispersion

Three companion papers established that the area-weighted mean surface gravity ⟨g⟩ of a small body can be estimated from a polyhedral shape model, without an independently determined density (Papers I–III). A single scalar, however, cannot say where on a body the gravity is high...

The Observer's Distortion Coefficient (Part II): Digital Topology and Computational Latency as a Replacement for Dark Matter: A 98% Predictive Fit for NGC 2403 and an Unfiltered 90.83% Universal Global Audit

The flat rotation curves of spiral galaxies remain one of the most prominent mysteries in astrophysics, traditionally attributed to hypothetical dark matter halos. In this paper, we expand our topological framework to a rigorous global ensemble analysis using the entire SPARC (Sp...

Geometric and Spectral Desingularization

There are two seemingly independent paradigms for resolving singularities: the geometric route — Arnold's σ-process, or blow-up, which replaces the singular point by the space of directions through it — and the spectral route — the Möbius transform, which turns sign-flipping (two...

Flexural–Torsional Buckling Behavior of FGP Curved Beams Based on a Modified Variational Method

Abstract This study presents a modified variational modeling method for the flexural–torsional buckling of functionally graded porous (FGP) curved beams. Unlike conventional methods that rely on strictly admissible functions, the proposed framework accommodates arbitrary orthogon...

Synergistic Constructionof Composite Conductive Networksand Particle Size Gradation toward High-Volumetric-Energy-DensityLiMn x Fe1– x PO4 Cathodes

Abstract The commercial deployment of LiMnxFe1–xPO4(LMFP) cathodes is hindered by the Mn3+ Jahn–Teller effect, low electronic conductivity, and low compacted density resulting from intensive gas evolution during conventional pyrolysis. Herein, a comprehensive modification strateg...