Research works

Epidemiology and prevalence patterns of head lice infestation in Isfahan Province, central Iran based on a surveillance study (2017–2024)

This study aimed to describe the demographic, temporal, spatial, and treatment-related epidemiology of head lice ( Pediculosis capitis ) infestation in Isfahan Province, central Iran, using population-based surveillance data. A retrospective population-based analysis was conducte...

Volcanic earthquake swarms at Izu-Oshima in 2023

Earthquake swarms are known to reflect underground fluid movement and stress changes. However, their occurrence patterns and the mechanisms underlying hypocenter migration remain poorly understood. In this study, we focused on two earthquake swarms that occurred at Izu-Oshima in...

Genomic, transcriptomic, and molecular predictors of response to neoadjuvant therapy in locally advanced rectal cancer: a narrative review

Total neoadjuvant therapy (TNT) has emerged as a key treatment paradigm for locally advanced rectal cancer, reducing distant metastasis rates and facilitating organ preservation in selected patients. However, treatment response remains heterogeneous, highlighting the need for bio...

Species discordance in diatom testing for drowning diagnosis: a biological passive sampling hypothesis with forensic implications

Diatom testing is a key technique for forensic drowning diagnosis, yet species discordance between diatom taxa in victim tissues and water samples from the recovery site remains a major medico-legal challenge, often misattributed to technical errors or post-mortem contamination....

Protocol to generate human T cell progenitors that repopulate the thymus

Human pluripotent stem cells (hPSCs) provide a powerful platform for generating T cell progenitors and investigating hematopoietic stem cell (HSC)-independent T cell development. Here, we present a protocol for the directed differentiation of hPSCs to generate early progenitors o...

Green synthesis, characterization, and antimicrobial evaluation of jackfruit seed starch-capped copper oxide nanoparticles in cold creams

Copper oxide nanoparticles (CuO NPs) were synthesized via a green approach by reacting copper sulfate with jackfruit seed starch in its native, annealed, and pregelatinized forms, and were characterized by UV–visible spectrophotometry, Fourier-transform infrared (FTIR) spectrosco...

Fusion at scale: Critical enablers in global energy transitions

Fusion is a promising sustainable energy source that can potentially contribute to achieving the most ambitious climate goals with firm carbon-free baseload electricity. Due to recent advancements, fusion is transitioning from a purely research stage to a pre-commercialisation ph...

MicroRNA-205-5p: a candidate biomarker and mechanistic mediator in polycystic ovary syndrome

The objective of this study was to investigate the impact of microRNA-205-5p (miR-205-5p) on clinical outcomes in patients with polycystic ovary syndrome (PCOS). Eighty PCOS patients and sixty-five healthy individuals were enrolled in this retrospective study. Serum levels of miR...

Latent profiles and predictors of fear of childbirth in late pregnancy: a parity-specific analysis

Fear of childbirth (FoC) is a common psychological concern among women in late pregnancy. Variation in reported prevalence and associated factors across studies reflects methodological heterogeneity and highlights the need for person-centred approaches to identify clinically mean...

RPPH1 drives ovarian cancer cells proliferation via CDK9-c-Myc axis

Dysregulation of the proto-oncogene c-Myc is a critical driver of ovarian cancer progression, yet the mechanisms governing its expression remain incompletely characterized. A systematic bioinformatic analysis was used to screen long non-coding RNA involved in the regulation of c-...

The impact of different learning modalities on dental students: a comparison of video, visual-text, and text-based instruction

Effective teaching methods are essential for improving dental students’ understanding of periodontal surgical procedures. Coronally advanced flap (CAF) surgery requires comprehensive knowledge of anatomical structures, surgical instruments, procedural steps, and possible complica...

Giant Well-Differentiated Liposarcoma of the Spermatic Cord Associated With Inguinal Hernia: Clinical Insights From a Case Report

Patient: Male

Anthropometric PHV-prediction models versus skeletal age in elite Chinese U12–U13 male soccer players: a cross-sectional study

Assessing biological maturity in youth soccer helps reduce maturity-related selection bias. Anthropometric peak height velocity (PHV) prediction models provide non-invasive, repeatable tools for maturity monitoring, but their performance relative to skeletal-age (SA) indicators r...

Frontal spectral entropy as a candidate individual-difference correlate of within-session accuracy change in youth soccer: an exploratory fixed-order study

Choking under evaluative pressure is often described in sport, yet its within-session neural and behavioural correlates in youth athletes remain poorly characterised. In this exploratory, fixed-order study we asked whether changes in soccer decision accuracy over the course of a...

Lifetime Concussions and Head Impact Exposure During Collegiate Athletics: A CARE Consortium Study

OBJECTIVE: Despite a growing interest in the long-term effects of concussion and repetitive head impacts (RHIs) on brain health, understanding is limited regarding the clinical and cognitive changes that may accrue during collegiate athletics. METHODS: Collegiate student-athletes...

Post-translational modifications in metabolic reprogramming: implications for metabolic therapy and immunotherapy in cancer

Cancer metabolism is characterized by profound reprogramming, yet the mechanisms enabling rapid and precise adaptation remain incompletely understood. This review establishes post-translational modifications (PTMs) as the central processing unit of oncogenic metabolic reprogrammi...

SERPINC1-mediated hereditary antithrombin deficiency with refractory pulmonary embolism: successful treatment with VA-ECMO and interventional thrombus aspiration

Venous thromboembolism (VTE) carries substantial global morbidity and mortality, with 50%–60% of disease variability attributed to genetic factors. Hereditary antithrombin deficiency (HATD), caused by pathogenic variants in the SERPINC1 gene, is an autosomal dominant thrombophili...

Intraprocedural cardiac computed tomography-fluoroscopy image fusion guided structural heart intervention: a proof of concept experience during transcatheter aortic valve implantation

Intraoperative image guidance using cardiac CT with fluoroscopy image fusion has been shown to facilitate structural heart interventions. However, there has been limited experience on CT image fusion with fluoroscopy using aortic root calcifications from intraoperative 3D cone-be...

Tissue-specific transcriptome analysis uncovers phenylpropanoid biosynthetic genes in Althaea officinalis

Althaea officinalis is a medicinal plant, rich in mucilage and polyphenols and traditionally used to relieve inflammation and irritation of respiratory, digestive, and urinary tissues. This study presents the first comprehensive transcriptomic analysis of A. officinalis revealing...

Rising burden and deepening inequalities: a national study of high BMI-related uterine cancer in the United States using GBD and NHANES data

OBJECTIVE: Uterine cancer mortality is rising in the U.S. while other cancer deaths decline, posing a major public health challenge. High BMI is the strongest modifiable risk factor, but its full burden and associated inequalities remain poorly characterized. METHODS: Using data...