Research works

The efficacy, immunogenicity and safety of the LZ901 vaccine for herpes zoster virus in adults 40 years of age or older: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

In previously completed Phase 1 and 2 clinical trials, a recombinant gE-Fc fusion protein subunit vaccine adjuvanted with aluminum hydroxide (called LZ901) demonstrated favorable safety profiles and elicited robust immune responses. This randomized, placebo-controlled, double-bli...

Sibling group sex composition and gender-typical educational choices

Educational choices are heavily stratified by gender. In this study we examine whether an important structural factor in the family of origin, sex composition of the sibling group, affects the emergence of the gender-typed preferences that may drive these choices. Using Swedish p...

Predictors of Postsurgical Outcomes in Trigger Finger Release: A Retrospective Analysis

Purpose This study aimed to examine factors associated with recurrent trigger finger and postoperative infection after trigger finger release (TFR) surgery. Methods A retrospective analysis was conducted to examine the variables that impact 4 postsurgical outcomes: postoperative...

Structured Documentary Access and Cross-Session Reconstruction Fidelity in Large Language Models: A Controlled Replication Across Three Agents and Three Domains

Large language models operating without persistent memory must reconstruct project context from whatever is available at query time. We report a controlled comparison of reconstruction fidelity under three conditions: no documentary access (SIN), access to the identical corpus wi...

Does resident–tourist value co-creation matter in promoting tourists’ environmentally responsible behaviour? The chain mediation role of perceived value and destination identification

Since tourists' environmentally responsible behaviour (ERB) has a profound impact on the overall sustainable development of a tourism destination, this research aims to examine the underlying mechanism between resident–tourist value co-creation (RVC) and ERB of tourists based on...

Cancer nanovaccine plus doxorubicin and immune checkpoint blockade overcomes chemoresistance and delays postsurgical recurrence

Chemotherapy for solid tumors has serious limitations due to acquired chemoresistance and frequent postsurgical recurrence. In this study, we developed a chemo-immunotherapy regimen combining a chemotherapeutic agent, a dendritic cell (DC)-activating cancer nanovaccine, and immun...

Comparative assessment of occlusal and proximal caries detection using an intraoral scanner and panoramic radiography

Recently, fluorescence-based caries detection has been integrated into intraoral scanners as a radiation-free adjunctive tool for caries assessment. However, evidence regarding the agreement of these systems with conventional diagnostic methods remains limited. Therefore, the aim...

Experiences of Diagnostic Radiographers Imaging People from Prison in Acute Hospitals in the UK: Phase One Findings from the EXPOSE Study

Introduction People in prison experience significant health disparities and rely on acute hospitals for secondary care, including diagnostic imaging. Despite this, little is known about how diagnostic radiographers experience imaging people from prison in acute hospital settings....

Visual elements in food packaging and consumer choice: a moderated mediation analysis of consumer satisfaction in the tea market

This study examines how consumer satisfaction moderates the relationship between visual packaging elements and purchase intention in low-involvement products. Whilst packaging design’s influence on purchase decisions is well-documented, understanding of boundary conditions remain...

Determining the minimal clinically important difference for EQ-5D-5L scores in patients undergoing primary total knee arthroplasty

Total Knee Arthroplasty (TKA) is a common procedure for knee osteoarthritis, but the Minimal Clinically Important Difference (MCID) for the EQ-5D-5L scale in TKA patients is not established. This study aims to determine the MCID for EQ-5D-5L in TKA patients. A prospective study w...

An engineered helper plasmid generates differential E4orf6 and L4-22/33K gene expression increasing AAV vector production

Helper plasmids that depend on native adenovirus gene expression have long been the standard for transient adeno-associated virus (AAV) production. Here, we demonstrate that engineering the required helper gene expression can greatly increase AAV production relative to the use of...

Identification and validation of CCL28 and CCL5 as chemokine biomarkers and pro-inflammatory mediators in acute pancreatitis: an integrated bioinformatics and experimental study

Acute pancreatitis (AP) is a common inflammatory disease of the exocrine pancreas. Its course ranges from a mild, self-limited illness to severe disease with organ failure. Current clinical tools do not reliably identify patients at risk of progression early in the disease course...

Global cloud phase monitoring from FY-3G multi-angle polarimetric observations using the new MAPLE-CP framework with independent multi-site lidar validation

Global cloud-top phase monitoring is constrained by an observing gap: passive imagers provide broad coverage but limited vertical phase information, whereas active sensors provide stronger physical constraints only along narrow tracks. Here we develop MAPLE-CP, a Multi-Angle Pola...

Integrative network toxicology and computational modeling uncover the mechanism of aflatoxin B1-induced nephrotoxicity

Aflatoxin B1 (AFB1) is a highly toxic mycotoxin that causes severe renal injury, yet the molecular basis of its nephrotoxicity remains poorly defined. Here, we integrated multi-omics data with computational modeling to elucidate the mechanisms of AFB1-induced kidney damage. Three...

Repositioning of cis-flupentixol for the suppression of ovarian cancer cell migration and invasion through ERK5 inhibition

Ovarian cancer (OC) remains the most lethal gynecological malignancy, largely because of its late-stage diagnosis and limited effective screening modalities. Despite therapeutic advances, high relapse rates and therapeutic resistance—particularly in metastatic disease—underscore...

Diagnostic accuracy of cone beam computed tomography in the detection of furcation perforations: an in vitro comparison with periapical radiography and micro-computed tomography

The furcation area is an anatomically complex region where the roots of multirooted teeth diverge. Visualizing pathologies and iatrogenic errors in this region is particularly challenging with conventional radiographic techniques due to factors such as superposition, root morphol...

Genotype-dependent miR-499/SOX5 axis regulation and its association with chronic low back pain risk and severity

The pathogenesis of chronic low back pain (CLBP) is complex and intricately linked to genetic predisposition. This study aimed to investigate the association between the microRNA-499 (miR-499) rs3746444 genetic polymorphism and CLBP, as well as to elucidate the underlying molecul...

A Scalable Cloud-Native Lakehouse Architecture for Epidemiological Forecasting and Constrained Resource Allocation

Disease surveillance systems in resource-constrained public health settings face two distinct challenges: detecting outbreak anomalies in real time, and translating those detections into operationally defensible resource-allocation decisions. Existing approaches typically address...

Decoding non-faradaic signal transduction in organic electrochemical transistor based biosensors

Organic electrochemical transistors (OECTs) combine amplification and transduction, making them attractive for biochemical sensing. Yet, the fundamental mechanisms by which OECTs convert biochemical binding events into electrical signals remain poorly understood, limiting their o...

Navigating intraoperative hypotension: rethinking traditional management for improved patient outcomes

Intraoperative hemodynamic instability and hypotension commonly occur in anesthetized patients and are associated with postoperative morbidity and mortality. A growing body of evidence establishes a strong correlation between intraoperative hypotension (IOH) and adverse events su...