Research works

Metabolic reprogramming enables transient survival and envelope remodelling in Staphylococcus aureus under dalbavancin treatment

Clinical failure of antibiotic therapy can occur in the absence of measurable resistance, yet the biological basis of this discordance remains poorly understood. Here, we identify a transient survival phenotype that limits dalbavancin efficacy and may contribute to treatment fail...

Spatial Working Memory Across Psychiatric Disorders in Young Adults

Objective: Impairments in spatial working memory (SWM) have been observed in several disparate psychiatric conditions.The present study investigated how SWM varied across a range of psychiatric disorders in a large sample of young adults using the Spatial Working Memory test from...

Pregnancy Ambivalence, History of Pregnancy, Condom Use, and Contraceptive Use Among U.S. Youth Experiencing Homelessness

Youth experiencing homelessness (YEH) are 5–8 times more likely than housed peers to become pregnant. A more nuanced examination of YEH pregnancy desire may better inform pregnancy and pregnancy prevention guidance. This study examined pregnancy ambivalence, pregnancy history, co...

Nonlinear association between platelet distribution width and futile recanalization in acute ischemic stroke patients undergoing mechanical thrombectomy

Platelet distribution width (PDW) is increasingly recognized as a potential biomarker in cardiovascular and cerebrovascular diseases. We, therefore, sought to clarify whether baseline PDW values predict futile recanalization (FR) among acute ischemic stroke (AIS) patients receivi...

Factors associated with oral hygiene practices among pregnant women: a cross-sectional study

This study aims to assess the general and pregnancy-specific oral health knowledge, levels of social support, and dental anxiety in pregnant women, as well as their association with oral hygiene habits. Pregnancy is associated with physiological and behavioral changes that may in...

LIB4RT: Automated generation of reactive-transport formulations from PHREEQC databases for implementation in multiphysics platforms

Reactive transport simulations in multiphysics platforms require accurate geochemical reaction and transport flux terms derived from thermodynamic databases and equilibrium speciation calculations. In practice, building these definitions manually from databases is time-consuming,...

Neuropathological Effects of Early Maternal Separation are Prevented by CORT113176, A Glucocorticoid Receptor Modulator

Early-life stress, such as maternal separation (MS), disrupts the pup´s hypothalamic–pituitary–adrenal (HPA) axis and causes neuropathological changes in several nervous system regions, including the spinal cord. This damage is driven by glucocorticoid receptor (GR) overactivatio...

Lipid accumulation product (LAP): a key indicator for metabolic dysregulation and inflammatory status in obesity

The Lipid Accumulation Product (LAP) is recognized as an indicator of lipid-induced cellular stress. While its predictive value for conditions like diabetes, liver disease, and metabolic syndrome is established, its specific correlations with individual metabolic and hematologica...

Drainage divide dynamics modulated by erosion-driven landscape adjustment in a low-deformation setting

The Vosges Mountains (northeast France) are a mid-altitude mountain range with peaks reaching ∼1500 m a.s.l., in a low-deformation setting. Despite this, they maintain significant topographic relief (up to ∼1000 m), characterized by deeply incised valleys and broad, rounded uplan...

Development and validation of the Paperless Examination Attitude Scale (PEAS) for digital assessment in higher education

Paperless examinations are now part of assessment practice in several Indian higher education institutions. However, institutions still have limited validated evidence on how students view compulsory digital examinations. This gap is important because examination use is different...

Species-specific functions of CSRP3 in satellite cell-driven muscle regeneration and relevance to porcine stem cell therapy

Skeletal muscle function deteriorates with injury, disease, or aging. While stem cell therapies offer therapeutic potential, concerns remain regarding the safety and efficacy of transplanted cells. Satellite cells (SCs), the primary endogenous stem cells responsible for muscle re...

Purely extradural meningioma presenting as an incidental sacro-iliac joint mass

We report the case of an asymptomatic 32-year-old woman in whom a 38-mm right sacroiliac mass was incidentally discovered on computed tomography. Computed tomography demonstrated a well-defined enhancing lesion centered on the right sacral ala and sacroiliac joint with sclerotic...

From fragmentation to integration: rethinking nutrition education in undergraduate medical curriculum in Pakistan through a mixed-methods study

Nutrition plays a central role in the prevention and management of both communicable and noncommunicable diseases, yet its integration within undergraduate medical education remains inconsistent. This study aimed to assess the current status of nutrition education in MBBS program...

Agenda setting in mutual fund markets: news, social media, and fund marketing in China

We analyze the effects of social attention on investment behavior. Using an original dataset covering 3,782 funds and over 240,000 news articles, we show that media attention, separated into traditional news media and social media, is associated with greater fund visibility and n...

Development and reproducible description of a multimodal physiotherapy intervention for pelvic floor health: a methodological report

Female pelvic floor disorders are frequently managed through interventions focused on pelvic floor muscle training (PFMT). However, pelvic floor function is increasingly recognised as being influenced by the interaction between breathing, posture, movement, and lumboabdominopelvi...

Affordances and Challenges of GenAI Feedback in Primary Students’ Scientific Drawing

GenAI can be a potential tool to facilitate students’ scientific practices through automated and real-time feedback. Yet, it is unknown how to design effective GenAI feedback to facilitate students’ progress in scientific practices, particularly at a primary age. In our study, we...

Too warm to play: temperature selectively constrains social behaviour in the Alpine marmot, Marmota marmota

Temperature is an important abiotic factor constraining animal physiology, yet its impact on social dynamics remains largely unexplored in wild endotherms. Here, we investigated the effect of temperature on social interactions of Alpine marmots, a cooperative breeder highly adapt...

Tobacco intercropping with Allium crops reshapes soil microbiome–metabolome interactions and improves plant health and tobacco leaf quality

Intercropping systems play important roles in improving soil conditions, enhancing crop performance and suppressing soil-borne diseases. However, the mechanisms by which tobacco– Allium intercropping regulates soil microecology, tobacco growth and leaf quality remain insufficient...

Identification and phenotypic profiling of subgroups with distinct cognitive aging trajectories

Cognitive aging is shaped by genetic variation, environmental factors, and health-related conditions. Until now, it is largely unclear why some individuals maintain their cognitive function, and others show progressive cognitive decline. This study uncovered determinants of disti...

A dual role of PIEZO2 in neuropathic pain: driving peripheral sensitization and enabling mechanical loading-induced analgesia

Mechanotherapy, a form of mechanical loading (ML), effectively relieves tactile allodynia-associated neuropathic pain by targeting sensitization points stimulated by PIEZO2, a mechanosensitive ion channel. However, the molecular mechanisms underlying peripheral sensitization and...