Research works

Comprehensive genetic counseling in pediatric cancer: Overcoming challenges and setting standards

Comprehensive genetic counseling in pediatric oncology is a complex and evolving field with unique challenges and considerations. There is a need for specialized genetic counseling services, particularly in cancer predisposition surveillance. The article emphasizes the crucial ro...

Governing the right to leisure: migrant leisure citizenship in São Paulo

Research on migrant leisure has documented constraints, discrimination, place-making and belonging, yet less attention has been paid to leisure as a social right that entails public responsibilities. This Research Note asks how Brazil's constitutional recognition of leisure, and...

Morphological and biochemical characterization of Capsicum annuum landrace Durgada for potential geographical indication status in Andhra Pradesh, India

Durgada chilli (also known as Potti mirchi ) is a traditional landrace of Capsicum annuum L., cultivated exclusively in Gollaprolu mandal of East Godavari district (presently in Kakinada district), Andhra Pradesh, India. This landrace is conserved and propagated by local farmers...

Patient-Reported Burden and Clinical Spectrum of Rheumatic Immune-Related Adverse Events After Immune Checkpoint Inhibitor Therapy in Lung Cancer: A Real-World Cohort Study

Background: Rheumatic immune-related adverse events (R-irAEs) after immune checkpoint inhibitor (ICI) therapy in lung cancer can be difficult to distinguish from cancer-related or degenerative musculoskeletal symptoms. Methods: In this single-center retrospective cohort, we analy...

The Bokkenrijders: Gangs of Drunkards or Military Operatives?

This article examines the Bokkenrijders—criminal gangs that raided Looz, the Lands of Overmaas, and parts of Germany between circa 1734 and 1795. It draws on sources, including trial records from the schepenbanken of communities in Belgian Limburg and critically analyses the soci...

Addition of low-load blood flow restriction training to conventional physiotherapy improves handgrip strength and function in patients with lateral epicondylitis at the short-term: A single-blind randomized clinical trial

Background Evidence regarding Blood Flow Restriction (BFR) training for the management of lateral epicondylitis (LE) remains limited and conflicting, although BFR has shown potential to improve muscle strength in other musculoskeletal rehabilitation settings. Objective To investi...

Student and surgeon perceptions of a robotic theatre live-link within the undergraduate curriculum

Abstract Explore student and surgeon perceptions of robotic theatre live-links as part of an undergraduate medical degree programme. During the surgical block, in the fourth year of a five-year medical programme at the University of Dundee, a robotic live-link session was introdu...

Combustion characteristics and mechanisms of highly ignition-sensitive Al-Si-Li/PTFE energetic materials in low-pressure environments

As aerospace technologies advance globally, the application fields of energetic materials have expanded from ground and near-ground levels to high altitudes. The decrease in ambient pressure associated with increasing altitude significantly affects the ignition reliability and st...

Size-Normalized Fecundity Reveals Reversed Geographic Patterns in the Porcelain Crab Pachycheles laevidactylus (Crustacea: Decapoda: Porcellanidae)

Fecundity in pleocyemate crustaceans is defined as the number of eggs produced per spawning event and is strongly dependent on female body size, which can limit direct comparisons among populations. To address this limitation, we evaluated geographic variation in fecundity in the...

VAEBAC: A representation-learning framework for proteome-scale prediction of amyloidogenic proteins and functional stratification of nucleic-acid-binding proteins

Abstract Motivation Nucleic-acid-binding proteins (NABPs) govern transcription, replication and genome organization, yet the distribution of aggregation susceptibility within regulatory proteomes remains unresolved. Here, we systematically examine amyloidogenic potential across t...

Investigating the anticancer potential of phytochemicals from the mangrove Rhizophora mucronata as inhibitors of lung cancer-associated proteins: Insights from multiscale computational and in silico analyses

Lung cancer remains the leading cause of cancer-related mortality worldwide, with a five-year survival rate of approximately 20–25% despite advances in targeted therapy and immunotherapy. There is a continuous need for novel, low-toxicity compounds capable of modulating key oncog...

Round versus tape sutures with interference fit anchors perform similarly in cadaveric glenoid and greater tuberosity biomechanical testing

Abstract Purpose To determine whether suture shape (flat-tape vs. round-wire) influences biomechanical performance at the suture-anchor–bone interface in interference-fit anchors used for rotator cuff and glenoid labrum repair. Methods Four matched pairs of human cadaveric should...

Mobilizing Dynamic‐Capability Microfoundations for Sustainability‐Oriented Innovation: The Role of Innovation Champions

ABSTRACT Organizations face growing pressure to respond to environmental and social challenges, yet research has not sufficiently explained how organizational actors mobilise dynamic‐capability microfoundations across the development of sustainability‐oriented innovations. Drawin...

Numerical simulation of motor neural system transmission models driven by multiplicative white noise: mean-square stability and convergence analysis

The signal transmission of motor neural system is inherently subject to random perturbations. Understanding the regulatory role of such noise in neural information encoding remains a central challenge in computational neuroscience and applied mathematics. This paper develops a pr...

Copper(II)/4‐Dimethylaminopyridine‐Mediated Oxidative Cyclization in Low‐Melting Mixtures: Access to Cyclopropane‐Fused Aza‐Heterocycles

A simple and efficient one‐pot approach has been developed for the stereoselective synthesis of 3‐azabicyclo[n.1.0]alkane derivatives, employing a low–melting mixture (LMM) composed of choline chloride (ChCl) and N , N ‐dimethylurea (DMU). This green and sustainable protocol faci...

Manufacturable topology optimization for thin-walled cross-sectional design

Thin-walled cross-sections are widely used in lightweight engineering structures because of their excellent stiffness-to-weight and torsional resistance characteristics. However, topology optimization of thin-walled cross-sections remains challenging because conventional density-...

Consumer preferences for vehicle types informed by direct and indirect emission estimates

As financial incentives for EVs wane and price parity approaches, engaging mainstream adopters is critical to sustaining market growth. While early adopters are driven by environmentalism and proactive information-seeking, the broader market remains hesitant due to knowledge gaps...

LED dimming and nonlinearity effects on link selection in hybrid VLC/RF networks

Abstract The codeployment of visible light communication (VLC) and radio frequency (RF) technologies has attracted research interest for indoor capacity enhancement. Many existing hybrid VLC/RF link selection schemes assume that the LED behaves as a perfectly linear device, an as...

Evaluation of surface roughness, microhardness, staining, and antimicrobial properties of zinc oxide–coated orthodontic thermoformed retainers – an in vitro study

Vacuum-formed retainers (VFRs) are the most commonly used removable orthodontic retention appliances owing to their esthetics, comfort, and ease of fabrication. However, they are prone to discoloration, microbial colonization, and reduced mechanical durability when used intraoral...

Validating Type 2 Diabetes Diagnoses Across the Madrid Hospital Network: Evidence for Secondary Use of the CMBD in the European Health Data Space

Background/Objectives: Hospital discharge data are increasingly reused for research and within health data spaces, but their value depends on accurate diagnostic coding. The validity of type 2 diabetes mellitus (T2DM) coding in the Spanish hospital discharge database (CMBD) had n...