Research works

Identification of potential breast cancer therapeutics from non-phenolic diarylheptanoids of Curcuma xanthorrhiza using network pharmacology and in silico methods

Abstract Background Curcuma xanthorrhiza , a widely recognized medicinal plant, contains three non-phenolic diarylheptanoids (NPDs) that exhibit diverse biological properties. Despite their known bioactivities, the precise molecular mechanisms underlying their therapeutic potenti...

Police Narratives on Ethical Issues of Big Data: A Sociotechnical Approach

Despite increasing integration of Big Data into law enforcement globally, few studies have examined how police officers construct ethical narratives around it. Drawing on Science and Technology Studies (STS), this article adopts a sociotechnical perspective to analyze how police...

Representing the entrepreneurial process with design in mind: walking the artefactual journey in space and time

Purpose This article synthesizes two strands of entrepreneurship discourse: the entrepreneurial design lens and the entrepreneurial narratives perspective to empirically reveal an introduced notion of an “artefactual journey” taken by a single entrepreneur. Design/methodology/app...

Cardiomyopathies in Pregnancy

Cardiomyopathies are uncommon but potentially life-threatening causes of cardiovascular disease in pregnancy. Pregnancy-associated hemodynamic changes may reveal unrecognized cardiomyopathy or exacerbate existing myocardial dysfunction. This review summarizes the diagnosis and ma...

Biotin-Functionalized Multi-Stimuli-Responsive Polymeric Prodrug for Receptor-Mediated and Mitochondria-Targeted Codelivery of Camptothecin and Protocatechualdehyde

Abstract Triple-negative breast cancer (TNBC) remains difficult to treat because of limited molecular targets and multidrug resistance. Here, we develop CPB, a biodegradable poly(ε-caprolactone)-polymeric prodrug nanoplatform integrating biotin-mediated uptake, triphenylphosphoni...

Temporal, Geographic, and Polysubstance Patterns in Orphine Analogue Detections

This cross-sectional study examines the temporal, geographic, and polysubstance patterns in orphine analogue detections.

Integration of ChatGPT to enhance English speaking skills among secondary school students in Pakistan

Abstract The integration of Artificial Intelligence (AI) into education is expanding rapidly, particularly in language learning. This study evaluated the effectiveness of a ChatGPT-assisted learning module in enhancing English-speaking proficiency in terms of range, accuracy, flu...

The choice of product strategy and marketing strategy for serial crowdfunders

Purpose Serial crowdfunding is a common phenomenon, and serial crowdfunders face multiple decisions. Most crowdfunding platforms implement one-time payments, while some platforms implement deferred payments. This paper explores the product and marketing strategies of serial crowd...

A Magnitude–Variability Framework for Dynamic River Water Quality Characterization

Continuous river water-quality monitoring increasingly captures short-term fluctuations that are poorly represented by conventional static assessments, yet frameworks for translating high-frequency observations into interpretable dynamic water-quality states remain limited. In th...

El español en Portugal. Dinámicas migratorias y educativas

Este trabajo actualiza la caracterización demolingüística del español en Portugal durante el periodo 2020-2026 a partir del análisis integrado de indicadores demográficos, migratorios y educativos. Se examina la evolución de la inmigración procedente de los países hispanohablante...

A randomized, controlled experimental medicine study of the novel Kv7 channel opener azetukalner in individuals with major depressive disorder and anhedonia

Abstract Major Depressive Disorder (MDD) is a common and debilitating disease. Kv7 potassium channels are relevant to reward processing and represent a novel target for depression and anhedonia. Azetukalner is a positive allosteric modulator of Kv7 channels. This phase II, random...

From pathogenesis to non-medical therapy: A review of exploring sensory and multi-sensory stimulation as a non-invasive treatment approach for Alzheimer’s disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, marked by the accumulation of amyloid-beta plaques, tau pathology, and synaptic dysfunction, ultimately leading to memory loss, cognitive decline, neuropsychiatric symptoms and neuronal degeneration that impair...

Maternal SARS-CoV-2 exposure and neonatal metabolic maturation during the first month of life: a longitudinal urinary metabolomics study

Abstract The first month of life is characterized by rapid metabolic adaptation as neonates transition from intrauterine to extrauterine life. Whether maternal SARS-CoV-2 infection influences these developmental trajectories remains largely unexplored. In this longitudinal study,...

grmcor : An R Package for Range-Restriction Bias Correction of Discrimination Parameters in the Graded Response Model

The Graded Response Model (GRM) is widely used for analyzing polytomous response data from attitude, personality, and character measurement instruments. However, when response data are collected from a range-restricted sample such as selected applicants, screened participants, or...

Embracing artificial intelligence in European auditing: the role of familiarity, motivation, organizational support and education in shaping perceived effectiveness

Purpose This study aims to examine how familiarity with artificial intelligence (AI), motivation and organizational support for AI, and demographic characteristics influence the perceived AI effectiveness among a sample of European auditors, as well as the moderating role of educ...

The Process of Customization in Shoulder Arthroplasty: Advancements in 3D Design and Manufacturing

Three-dimensional (3D) printing has emerged as a powerful tool in joint replacement surgeries, enabling the creation of custom implants that address complex anatomical deformities. In shoulder arthroplasty, particularly in cases involving severe glenoid bone loss or fracture, cus...

Netnography in accounting and accountability research: methodological application and future directions

Purpose This study reviews the use of netnography as a methodological approach within accounting and accountability research, focusing on how the method is operationalised in empirical studies. While netnography has gained increasing visibility in the field, limited attention has...

A trust-aware computational framework for mental health risk amplification and propagation in online social networks

Computational social systems are facing big challenges because of the rapid dissemination of inaccurate information, evidenced by the growing number of negative impacts on individual and collective mental health. Although extensive research has investigated the dissemination of f...

Carbohydrate-to-fat ratio is positively associated with comprehensive frailty across protein-intake levels in older adults

Abstract Purpose Diet influences frailty, and protein intake has been a prime focus of prevention. However, frailty remains prevalent, even among older adults with relatively high protein intake, suggesting the influence of remaining energy distribution between carbohydrates and...

Combined effects of kombucha consumption and aerobic exercise on oxidative stress and metabolic parameters in Wistar rats

Abstract Background Kombucha, a fermented tea containing symbiotic bacteria and yeast, and aerobic exercise each confer distinct health benefits, but their combined effects remain poorly understood. This study investigated the combined effects of consuming kombucha fermented for...