Research works

No difference in alloimmunization of pregnant adults with sickle cell disease exposed to chronic versus on‐demand transfusions: A two‐center retrospective cohort study

Abstract Background Pregnant people with sickle cell disease (SCD) experience high morbidity and mortality, even when RBC transfusion is safe and available. There is a lack of consensus on transfusion use partly due to concern for alloimmunization. This study examined alloimmuniz...

Fibrinogen-to-Albumin, Platelet-to-Albumin, and Creatinine-to-Albumin Ratios in the Assessment of Preeclampsia Severity: A Retrospective Case–Control Study

Background: Preeclampsia (PE) is a multisystem pregnancy disorder associated with endothelial dysfunction, inflammation, and coagulation abnormalities. This study evaluated the fibrinogen-to-albumin ratio (FAR), platelet-to-albumin ratio (PAR), and creatinine-to-albumin ratio (Cr...

A Decade of Progress and Achievements

Purpose/Aim: This report aims to describe the evolution, achievements, and impact of the clinical nurse specialist (CNS) role within cancer services in the State of Qatar from 2011 to 2024. Description: A descriptive design guided by Hamric’s Integrative Framework for Clinical Nu...

ESR1 mutations are associated with enhanced MTORC1 signaling in a context-dependent manner

Abstract ESR1 mutations are a driver of endocrine therapy resistance in breast cancer, however their impact on protein signaling pathways and clinical outcomes remains poorly understood. We analyzed the transcriptomic, proteomic, and phosphoproteomic landscape of tumors harboring...

Engineered MspA Nanopores for Real-Time Detection of Insulin, Its Pharmaceutical Analogues, and Degradation Products

Abstract Nanopore sensors have demonstrated single-molecule resolution for nucleic acids and small molecules, yet the discrimination and detection of folded proteins in complex biological matrices remains a challenge. Insulin is a demanding test case: it circulates in blood at pi...

Targeted genome recovery of under-sequenced microbes from the Sequence Read Archive STAT

Most microbial species are represented by a single genome in public databases. The lack of genomes for these ‘singleton’ organisms limits our understanding of their pan-genome diversity and evolution. Although the Sequence Read Archive (SRA) contains millions of sequencing datase...

Navigating the Unknown: A Surgical Perspective on Thoracic ALK-Positive Histiocytosis With Literature Review

Anaplastic lymphoma kinase (ALK)-positive histiocytosis (APH) is a rare disorder characterized by the accumulation of cells derived from monocyte-macrophage-dendritic cells.Thoracic APH is incredibly unusual and thus creates a diagnostic challenge.In this study, we report a case...

20.8% Peak External Quantum Efficiency of Red (619 nm) InGaN/GaN MicroLEDs

Abstract Red-emitting indium gallium nitride (InGaN) micro-light-emitting diodes (μLEDs) remain challenging due to reduced radiative efficiency at the high indium compositions required for long-wavelength emission. Here, we demonstrate InGaN/GaN red μLEDs emitting at 619 nm that...

Synchronisation analysis for fractional-order discrete-time high-order BAM neural networks with time-varying delays

This paper investigates the problem of quasi-synchronisation (QS) and complete synchronisation (CS) for a class of fractional-order discrete-time high-order bidirectional associative memory neural networks (DFBHONNs) with time-varying delays. Firstly, by employing the Caputo frac...

Prenatal stress reprograms placental signaling and opposes maternal immune activation effects in the fetal brain

Abstract Prenatal psychosocial stress and maternal immune activation (MIA) increase risk for overlapping offspring psychiatric disorders, but whether they influence fetal neurodevelopment through shared or distinct mechanisms is unclear. Positioned at the interface of maternal an...

Heterogeneity and ontogeny of mouse thymic macrophages reveal a requirement for Csf1r-expressing myeloid cells during early T cell development

Thymic macrophages (TMs) maintain tissue homeostasis by clearing the large numbers of apoptotic cells generated during T cell development, but how TM heterogeneity relates to their developmental origin and role in thymocyte maturation remains incompletely understood. Using comple...

Comparative assessment of perennial grasses for restoring degraded semi-arid agroecosystems under contrasting moisture regimes

Although perennial grasses are increasingly recognized for restoring degraded lands, their restoration potential under contrasting moisture regimes in semi-arid agroecosystems remains poorly understood. Identifying grass species that can simultaneously enhance productivity, soil...

A fractional integral ghost-structure method for a space-fractional anisotropic monodomain model in realistic bi-ventricular cardiac electrophysiology

This paper proposes a space-fractional anisotropic monodomain model for simulating action potential propagation in deforming cardiac tissue. The model incorporates an anisotropic conductivity tensor that depends on the local fiber orientation and evolves with tissue motion, there...

Integrated Metabolome and Transcriptome Analyses Reveal Candidate Regulatory Networks of Anthocyanin Biosynthesis in Cinnamomum burmanni (Nees et T. Nees)

Cinnamomum burmanni (Nees et T. Nees) Blume represents an economically valuable evergreen arbor celebrated for its essential oils; nevertheless, its floral and foliar anthocyanin metabolic profile remains largely uncharacterized. In this investigation, integrated LC-MS/MS-based t...

Enhancing debt recovery process of Islamic banks using a Ju’alah -based decentralized model

Purpose This study aims to derive a compatible debt recovery approach for Islamic banks based on Ju’alah contract after identifying the key limitations of currently used approaches, such as inhouse debt recovery, outsourcing debt collection and debt factoring. Design/methodology/...

Effects of Double-Primer Placement on Rock Fragmentation at Kevitsa Open Pit Mine

Abstract To address the lack of systematic production-scale evaluation of the effects of double-primer placement on blasting performance, this study presents a comparative analysis of two primer configurations. The double-primer placement consists of two primers positioned 2 m ab...

Refusing to Harness a River

Abstract This article considers conflict between mid-twentieth-century dryland farmers in Saskatchewan, Canada, and a provincial government intent on irrigation. As part of a high modernist multipurpose water development project undertaken with the Canadian federal government, Sa...

It Must Have Been Love (But It's Over Now): Thematic Changes in Popular U.S. Song Lyrics Across 4+ Decades

Over time, U.S. marriage rates have decreased, as people increasingly expect romantic relationships to satisfy high-level needs. Concurrently, interest in sexualized relationships (e.g., hook-ups; consensual nonmonogamy) has increased. Reflecting these patterns over time, song ly...

Betaine supplementation modulates mitochondrial and redox-related adaptations in premenopausal women with overweight: a randomized controlled trial

The aim of this study was to investigate the effects of betaine supplementation on mitochondrial and redox-associated parameters in premenopausal women with overweight or obesity. We hypothesized that betaine enhances selected mitochondrial enzyme content and improves antioxidant...

Economic Burden of Herpes Zoster Ophthalmicus in New Zealand: A Retrospective Cohort Cost Analysis

Purpose: The aim of this study was to estimate the direct health care cost burden of herpes zoster ophthalmicus (HZO) in New Zealand and to evaluate potential implications for shingles vaccination policy. Methods: This retrospective cohort study analyzed 869 participants with HZO...