University of Utah

Health Literacy and Other Factors Associated With Recent Dental Care Utilization Among Mexican-American Adults

Introduction and Aims Health literacy (HL) plays a role in determining whether patients can successfully navigate dental care systems and access needed care. This study examines the association between HL on recent dental care utilization among Mexican-American young adults durin...

Infant hippocampal and amygdala volume in an observational follow-up from a randomized clinical trial for maternal prenatal depression

Abstract Prenatal maternal depression may have intergenerational effects on offspring brain development, with potential socioemotional consequences. This observational follow-up study examines brain development and subsequent negative emotionality among 109 infants born to mother...

Star Wars at Fifty

This symposium celebrates the 50th anniversary of Star Wars (1977) with nineteen short essays from scholars who discuss its meaning, impact, and legacy. The essays examine the migrations and manifestations of the Star Wars universe across media, including animation, video games,...

Cosmological Constraints from Full-scale Clustering and Galaxy–Galaxy Lensing with DESI DR1

Abstract We present constraints on cosmic structure growth from the analysis of galaxy clustering and galaxy–galaxy lensing with galaxies from the Dark Energy Spectroscopic Instrument (DESI) Data Release 1. Our analysis includes four samples drawn from the Bright Galaxy Survey (B...

The impact of non-medical determinants of health on patient-reported outcomes in pediatric lupus: A CARRA registry study

Objectives Social determinants of health (SDOH) and race are associated with disease activity, including lower achievement of the low lupus disease activity state (LLDAS), but it is unknown whether these factors are associated with patient-reported outcomes (PROs). Among a cohort...

Effect of Vasopressin Initiation Threshold on Septic Shock Mortality

Importance The optimal vasopressor dose at which to initiate a second vasopressor in patients with septic shock is uncertain. Objective To compare the effects of hospital-level strategies initiating vasopressin infusion at a lower threshold vs a higher threshold on outcomes in pa...

Dietary and lifestyle quality and endometrial cancer: Incidence and survivorship outcomes—An umbrella review of systematic reviews and meta-analyses

Composite dietary and lifestyle indices capture the combined effects of multiple health-related behaviours and may better reflect real-world cancer risk and survivorship than single exposures. This umbrella review aimed to evaluate and grade the strength of evidence for associati...

Exploration of the genetic architecture of ANCA-associated vasculitis

Background Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a complex autoimmune disease with distinct clinical and serological subtypes. Previous genome-wide association studies (GWAS) have identified several susceptibility loci, particularly within the major h...

Development of a Screening Workflow for the Halogenation of Nitrogen Heterocycles with Vanadium-Dependent Haloperoxidases

Abstract The halogenation of nitrogen heterocycles is a privileged transformation for accessing important synthetic intermediates and biologically active targets in medicinal chemistry. Despite the importance of N-heterocycle halogenation, current methods rely on reagents or cata...

Interim Update on Reactive Infectious Mucocutaneous Eruption ( RIME )

ABSTRACT Reactive infectious mucocutaneous eruption (RIME), a term describing blistering skin and mucosal lesions, is a term coined by a group of Pediatric Dermatology Research Alliance (PeDRA) researchers and first published in 2021. Since that time, the literature has grown wit...

The effectiveness of targeted visuals: Improving awareness of acral lentiginous melanoma among Hispanic and African American participants

Acral lentiginous melanoma (ALM) is an aggressive type of melanoma that disproportionally impacts people of color, with rising incidence among Hispanic/Latino populations and the highest mortality rate among African Americans. Given these disparities, innovative strategies for co...

The use of real‐world data in health services research for dementia care: A scoping review

Abstract Health services research (HSR) is critical to informing dementia care and often relies on real‐world data (RWD); however, RWD use in HSR has not been systematically mapped in the United States. Following previous researchers and Preferred Reporting Items for Systematic R...

Variation in High Value Care for Low Back Pain Among Older Adults Enrolled in Medicare Advantage Plans

IMPORTANCE: Low back pain (LBP) is a major cause of disability and poor quality of life among older adults. Clinical guidelines recommend non-pharmacological therapies, such as physical therapy (PT), as the first-line treatment for high-value care. Despite the fact that more than...

Experimental snowball earth viscosity drives the evolution of motile multicellularity

During the 70-million-year Cryogenian Snowball Earth glaciations, low ocean temperatures beneath global sea ice increased water viscosity over 3-fold. Unicellular eukaryotes in this environment would have faced severe constraints on movement and nutrient uptake, while nascent mul...

Predicting the clinical course of advanced systemic mastocytosis on treatment with avapritinib or midostaurin

Abstract Advanced systemic mastocytosis (AdvSM) is driven by KIT D816V in approximately 95% of cases. Accurate assessment and prediction of clinical course and disease outcome before and during treatment with the KIT inhibitors midostaurin and avapritinib may facilitate optimizat...

Use of Anticoagulation Among Patients With Atrial Fibrillation or Atrial Flutter in the United States

BACKGROUND: Oral anticoagulation (OAC) remains underused in patients with atrial fibrillation or flutter at high risk of ischemic stroke. We aimed to characterize documented OAC prescribing at diagnosis and during 1-year follow-up and identify factors associated with baseline OAC...

Current opinion on simulation in family planning

Purpose of review We aim to review novel family planning simulation models published since 2017. We will focus primarily on models for simulating abortion care, given the increased need for simulation education in this area post-Dobbs. Recent findings Since the last current opini...

Effects of one night of sleep deprivation on single- and dual-task gait

Abstract Sleep deprivation (SDEP) impairs cognitive control, which may affect movements that rely on these processes, such as walking. To test whether gait changes after one night of SDEP reflect reduced cognitive capacity, we compared its effects with those of dual-task walking...

Determination of inter-individual differences in humeral head centre translations in subjects with healthy shoulders

Abstract The aims of this study were to (i) quantify glenohumeral (GH) joint translations in healthy shoulders, (ii) assess subject-specific variability in GH translations, (iii) determine whether bony joint geometry (glenoid height, width, retroversion, inclination, GH aspherici...

Multivariate analysis identifies distinct latent components and highlights the contribution of motor cortex neurochemistry to clinical variance in amyotrophic lateral sclerosis

Abstract Amyotrophic lateral sclerosis (ALS) is marked by substantial clinical heterogeneity across motor and extramotor domains, yet how different neuroimaging modalities jointly relate to this heterogeneity remains poorly understood. Prior ALS neuroimaging studies have largely...