University of Rochester Medicine

Early PROMIS Outcomes After Cubital Tunnel Release With and Without Anterior Transposition

BACKGROUND: Cubital tunnel syndrome is the second most common upper extremity neuropathy and is treated surgically with either in situ decompression or anterior transposition of the ulnar nerve. Although both approaches achieve comparable long-term outcomes, variation persists in...

Plasma Phosphorylated Tau 217 Percentage by Race and Ethnicity in Preclinical Alzheimer Disease

Importance In trials targeting preclinical Alzheimer disease (AD), defined as amyloid pathology without cognitive symptoms, racial and ethnic differences in plasma phosphorylated tau 217 percentage (%p-tau217) may influence screening eligibility. Objective To characterize racial...

A living systematic review, meta-analysis, and open data resource of trials of MDMA-assisted therapy for PTSD

Abstract 3,4-Methylenedioxymethamphetamine (MDMA) has emerged as a potential treatment for post-traumatic stress disorder (PTSD). However, rapidly changing evidence in a fast-moving field can be challenging to integrate. Here, we present a living systematic review and open-data m...

Well-Being and Occupational Engagement in Breast Cancer Survivors

Date presented: April 25, 2026 Primary Author and Speaker: Christine A. Linkie, chrislinkie@hotmail.com

Enhancing Postpartum Care for Incarcerated People With Opioid Use Disorder: A Multimodal Intervention for Jail Staff

Incarcerated postpartum individuals with opioid use disorder (OUD) are vulnerable to poor health outcomes, but care provision in custody for this population is variable. Addressing their distinct needs is crucial for improving correctional health care for postpartum people. In th...

Nicotine replacement therapy sampling for cigarette cessation in dental care: A National Dental Practice‐Based Research Network cluster randomized clinical trial

BACKGROUND AND AIMS: Cigarette smoking is detrimental to oral health. Oral health professionals rarely prescribe smoking cessation medications. Nicotine replacement therapy sampling (NRTS), providing brief starter courses of NRT, could improve provision of NRT and promote cessati...

Impact of on-site mobile CT imaging on prehospital patient management during the Munich Oktoberfest: a retrospective observational before–after study at a mass gathering

Abstract Background Mass gatherings such as the Munich Oktoberfest increase demand on Emergency Medical Services (EMS), particularly for trauma patients requiring imaging. Suspected mild traumatic brain injury (mTBI) often necessitates hospital referral and diagnostic imaging, pl...

Jaw Dimensions, Skeletal Maturation, and Salivary Hormones in Adolescents With Normal and Increased Body Mass Index: A Cross‐Sectional Study

ABSTRACT Objective To evaluate jaw dimensions, skeletal maturation, and salivary hormonal and adipokine levels in adolescents with normal and increased body mass index (BMI). Setting and Sample Population This cross‐sectional study included 50 adolescents (mean age 13.54 ± 1.39 y...

Characterizing the B-cell senescence signature in driving the disease phenotype in COPD/emphysema

Increased cellular senescence is a key mechanism underlying chronic inflammation and airway remodeling in chronic obstructive pulmonary disease (COPD). Yet, the cellular composition and molecular features of the senescent microenvironment in COPD remain poorly understood. To addr...

Brain signatures of body mass index predict cardiometabolic and respiratory disease status

Abstract Despite advances in brain biomarkers using neural networks, the effects of body mass on brain structure have been neglected, particularly in connection with noncommunicable diseases. Here, we isolated brain biomarkers of body mass index (BMI) and evaluated their associat...

Cyclic nucleotide signaling through phosphodiesterase 1 inhibition and its interaction with the competing endogenous RNA network regulates cognition

Background Phosphodiesterase 1 (PDE1) has been demonstrated to be a potential drug target for a variety of diseases, ranging from peripheral system disease (PSD) to central nervous system disorders (CNSD). However, how cyclic nucleotide signaling, regulated by PDE1, particularly...

Infections in MonumenTAL-1: a plain language summary of talquetamab treatment for relapsed/refractory multiple myeloma

Plain Language SummaryWhat is this summary about?This summary describes infection and immune cell data of participants receiving talquetamab for relapsed/refractory multiple myeloma (RRMM) in the MonumenTAL-1 study.What were the results?Almost 60% of participants receiving talque...

Older Patients and Conservative Kidney Management

Importance In the US, dialysis remains the reflexive treatment option for end-stage kidney disease. Conservative kidney management (CKM), a nondialytic pathway, is infrequently utilized despite the burden dialysis often imposes on patients, caregivers, and health care systems. Ob...

Local Adaptations of Hospital in Home: Variations in Structure and Implementation Across Six VA Programs

ABSTRACT Background The VA Hospital in Home (HIH) model of care delivers acute‐level hospital care to Veterans at home across the country. We aim to examine the similarities and differences in the structure and implementation of existing HIH programs across sites to identify best...

Real‐world outcomes of nivolumab‐ AVD and brentuximab vedotin‐ AVD in paediatric and adult advanced‐stage Hodgkin lymphoma

Summary Brentuximab vedotin (BV)‐doxorubicin, vinblastine and dacarbazine (AVD) and nivolumab (N)‐AVD have transformed the frontline treatment of advanced‐stage Hodgkin lymphoma (HL), yet real‐world comparative data remain limited. In this multicentre retrospective study across 1...

Association of Eplet Mismatch Load and Allograft Injury in Kidney Transplant Recipients

Abstract Introduction Eplet mismatch load is a molecular measure of donor–recipient histocompatibility that has been associated with alloimmune outcomes after kidney transplantation. However, its relationship with comprehensive markers of early allograft injury remains incomplete...

Susceptible perinatal windows to arsenic exposure and serum antibody levels in children

Several cohorts have documented potential immunotoxic effects of arsenic in pediatric populations, however, the identification of susceptible windows to arsenic exposure remains poorly investigated in relation to vaccine-specific antibody responses. The present study examines per...

Antibody-Drug Conjugate-Associated Oral Toxicities

Aim: Antibody-drug conjugates (ADCs) are an emerging class of anti-cancer therapies, designed to specifically target cancer cells while minimizing impact on healthy tissues; however, they are associated with a broad spectrum of toxicities. The goal of this paper is to review the...

An Investigation of Sleep Macro‐ and Microarchitecture by APOE Genotype

Objectives Apolipoprotein E ε4 ( APOE ε4 ), a robust genetic risk factor for Alzheimer's disease (AD) is associated with functional connectivity deficits and amyloid pathology in brain regions involved in sleep regulation. Thus, alterations in sleep architecture may be one pathwa...

Care of the Infant With Congenital Cytomegalovirus Infection: Clinical Report

This clinical report addresses recognized knowledge gaps regarding congenital CMV infection (cCMV) in infants and expands on information present in the 2024-2027 Red Book. The clinical report reviews the epidemiology of cCMV, clinical manifestations of cCMV disease and cCMV with...