Risk of hepatitis B reactivation following corticosteroids for tuberculous meningitis

Abstract

Abstract High-dose corticosteroids may cause reactivation or relapse of hepatitis B virus infection. We investigated the virologic and clinical consequences of 6-8 weeks dexamethasone in hepatitis B virus infected/exposed/unexposed HIV-negative adults with tuberculous meningitis enrolled into a placebo-controlled trial. Dexamethasone was not associated with viral reactivation or increased liver injury.