Hospital for Tropical Diseases

Urine-based detection of Leishmania donovani antibodies using recombinant aurora kinase and otubain cysteine peptidase for noninvasive diagnosis of visceral leishmaniasis

ABSTRACT Visceral leishmaniasis (VL) is a fatal neglected tropical disease that requires early and accurate diagnosis to reduce mortality and interrupt transmission. Although parasitological confirmation using splenic aspirates is the gold standard, it is invasive and hazardous,...

A systematic review of ultrasound to predict severe disease in patients with dengue and other viral infections associated with hemorrhagic fevers

Background Viral infections associated with hemorrhagic fevers (VaHFs) cause millions of cases each year across a broad geography with severity ranging from asymptomatic cases to clinical disease with a high case fatality rate. Commonalities in pathophysiology across VaHFs includ...

Global prevalence of colistin resistance, mcr gene variants, and sequence types in Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, and Stenotrophomonas maltophilia: a systematic review and meta-analysis

Abstract Background Due to the increasing prevalence of infections caused by multidrug-resistant (MDR) Gram-negative bacteria, colistin has become an important therapeutic option. However, the rapid emergence of resistance to this antimicrobial agent, mediated by mechanisms such...

Beyond traditional criteria: CRP and fibrinogen as biomarkers of metabolic syndrome in ART-treated people living with HIV and their association with HIF-1α rs11549465

Metabolic syndrome (MS) is highly prevalent among people living with HIV (PLWH) receiving antiretroviral therapy (ART) and is driven by persistent low-grade inflammation. Hypoxia-inducible factor 1 alpha ( HIF-1α ) polymorphisms may influence inflammatory pathways underlying MS....

Risk of hepatitis B reactivation following corticosteroids for tuberculous meningitis

Abstract High-dose corticosteroids may cause reactivation or relapse of hepatitis B virus infection. We investigated the virologic and clinical consequences of 6-8 weeks dexamethasone in hepatitis B virus infected/exposed/unexposed HIV-negative adults with tuberculous meningitis...

Subnational Heterogeneity in RSV Seasonality in Tropical Colombia, 2022–2024

Abstract Background RSV transmission in tropical settings is often assumed to occur year-round, and preventive strategies are frequently recommended accordingly. However, sub-national variation in epidemic timing remains incompletely characterized. Granular local surveillance dat...

Growth Parameters in Sudanese Children and Adolescents Living with HIV/AIDS: Findings from a Retrospective Cohort Study

Abstract Background Human immunodeficiency virus (HIV) remains a major global public health problem. Globally, about 39.9 million people are living with HIV (LWHIV), with two-thirds in Africa. HIV infection adversely affects growth in children and adolescents LWHIV. Highly active...

Vaccine preparedness for Bundibugyo virus and lessons learned

The ongoing 2026 outbreak of Bundibugyo virus (BDBV) in the Democratic Republic of the Congo and Uganda is the largest so far on record. Despite experience from previous Ebolavirus outbreaks, the current lack of vaccines against BDBV underscores a recurring failure in proactive p...

Autoantibodies neutralizing type I interferons underlie a third of cases of Chikungunya virus encephalitis or myelitis

Abstract Chikungunya virus (CHIKV) infection is typically not life-threatening but may, in rare cases, affect the central nervous system (CNS). In three cohorts of confirmed CHIKV cases from Martinique (French overseas territory) and Brazil (patients aged 0–89 years, n = 245), 20...

Neonatal antibody levels and treatment outcomes following maternal vaccination among NICU infants exposed to COVID-19 during pregnancy

The COVID-19 pandemic has profoundly affected maternal and child health worldwide, with pregnant women being particularly vulnerable to complications. Vaccination during pregnancy has been shown to generate protective antibodies offering passive immunity to neonates, though conce...