Hospital for Tropical Diseases

Vaccine preparedness for Bundibugyo virus and lessons learned

The ongoing 2026 outbreak of Bundibugyo virus (BDBV) in the Democratic Republic of the Congo and Uganda is the largest so far on record. Despite experience from previous Ebolavirus outbreaks, the current lack of vaccines against BDBV underscores a recurring failure in proactive p...

Autoantibodies neutralizing type I interferons underlie a third of cases of Chikungunya virus encephalitis or myelitis

Abstract Chikungunya virus (CHIKV) infection is typically not life-threatening but may, in rare cases, affect the central nervous system (CNS). In three cohorts of confirmed CHIKV cases from Martinique (French overseas territory) and Brazil (patients aged 0–89 years, n = 245), 20...

Neonatal antibody levels and treatment outcomes following maternal vaccination among NICU infants exposed to COVID-19 during pregnancy

The COVID-19 pandemic has profoundly affected maternal and child health worldwide, with pregnant women being particularly vulnerable to complications. Vaccination during pregnancy has been shown to generate protective antibodies offering passive immunity to neonates, though conce...