Angkor Hospital for Children

Community perceptions, trust, and experiences of malaria clinical research and participation in rural Cambodia

INTRODUCTION: Understanding community perspectives on malaria treatment and research participation is important for designing ethically appropriate community engagement strategies, strengthening informed consent, and improving the conduct of clinical research while supporting dis...

Persistence of immune responses 5 years after vaccination with a single dose of typhoid conjugate vaccine (TCV) in Nepalese children

Background A single-dose typhoid conjugate vaccine (TCV) has been recommended in endemic settings. Here we report the 5-year immunogenicity results post a single dose of TCV in Nepal. Methods We conducted a participant- and observer-blinded randomised trial (RCT) in Lalitpur, Nep...

Snakebite Envenoming in Zambia: From Neglect to National Public Health Priority

Snakebite envenoming (SBE) remains a major yet neglected public health challenge that disproportionately affects poor rural and agricultural communities in Zambia. Despite increasing recognition of SBE as a neglected tropical disease by the World Health Organisation (WHO), the co...

Risk of hepatitis B reactivation following corticosteroids for tuberculous meningitis

Abstract High-dose corticosteroids may cause reactivation or relapse of hepatitis B virus infection. We investigated the virologic and clinical consequences of 6-8 weeks dexamethasone in hepatitis B virus infected/exposed/unexposed HIV-negative adults with tuberculous meningitis...

Estimating enteric fever seroincidence in rural western Cambodia: Findings from a population-based cross-sectional serosurvey

Background: Enteric fever, caused by Salmonella enterica serovars Typhi and Paratyphi, remains an important cause of febrile illness in low- and middle-income countries (LMIC). However, the exact burden is difficult to estimate due to limitations in diagnosis and surveillance.Met...

A novel framework for quantifying the clinical impact of substandard and falsified antimicrobials: Application to typhoid fever

Substandard and falsified (SF) medicines are a neglected public health threat, with an estimated 7% of antimicrobials in low- and middle-income countries being SF. However, quantifying their clinical impact remains challenging. We developed a general framework for estimating popu...