Oxford University Clinical Research Unit

Balancing altruism, risk and ethics: Vietnamese students’ views on human challenge studies

Introduction Human challenge studies (HCS) have been proposed to accelerate the development of health interventions and strengthen research capacity in low- and middle-income countries. However, implementation in settings such as Vietnam, where clinical care facilities and resear...

Risk of hepatitis B reactivation following corticosteroids for tuberculous meningitis

Abstract High-dose corticosteroids may cause reactivation or relapse of hepatitis B virus infection. We investigated the virologic and clinical consequences of 6-8 weeks dexamethasone in hepatitis B virus infected/exposed/unexposed HIV-negative adults with tuberculous meningitis...