Oxford University Clinical Research Unit

Early best available antibiotic therapy for multidrug-resistant gram-negative bloodstream infections: a target trial emulation

Background The effect of timely appropriate antibiotics in multidrug-resistant Gram-negative bacteria (MDR-GNB) bloodstream infections (BSIs) remains uncertain. Robust evidence is needed to inform diagnostic and treatment strategies, especially across settings with high antimicro...

Functional antibody responses and protection against symptomatic dengue

Exposure to dengue virus (DENV) triggers the development of anti-viral antibodies that may contribute to either protection or disease progression. Antibodies exist in different isotypes and subtypes, with diverse specificities and functions. IgG antibodies are produced during pri...

Balancing altruism, risk and ethics: Vietnamese students’ views on human challenge studies

Introduction Human challenge studies (HCS) have been proposed to accelerate the development of health interventions and strengthen research capacity in low- and middle-income countries. However, implementation in settings such as Vietnam, where clinical care facilities and resear...

Risk of hepatitis B reactivation following corticosteroids for tuberculous meningitis

Abstract High-dose corticosteroids may cause reactivation or relapse of hepatitis B virus infection. We investigated the virologic and clinical consequences of 6-8 weeks dexamethasone in hepatitis B virus infected/exposed/unexposed HIV-negative adults with tuberculous meningitis...