How age and sex interaction is associated with immune aging with implications for vaccines and age-related autoimmunity
Abstract
Immunosenescence is not a uniform decline but a trajectory shaped jointly by age and sex. Using continuous high-dimensional immunophenotyping, we show that aging T cells accumulate a senescent signature of CD28 loss and CD57 gain, and that males reach an inverted CD4:CD8 ratio earlier and more severely than females. We argue that age-by-sex stratification should guide vaccination and geroprotective strategies in an aging population.
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Authors: Reza Gheitasi, Mahnaz Rezaei, Parvaneh Nafisi Fard, Daniela Roel, Sabine Baumgart, Diana Dudziak, Norman Rose, Simon M. Petzinna, Thomas Kamradt, Carsten Watzl, Mathias W. Pletz, Valentin S. Schäfer
Institutions: Jena University Hospital, Friedrich Schiller University Jena, University of Augsburg, Isfahan University of Medical Sciences, TU Dortmund University, University Hospital Bonn, Leibniz Research Centre for Working Environment and Human Factors