Diana Dudziak

How age and sex interaction is associated with immune aging with implications for vaccines and age-related autoimmunity

Immunosenescence is not a uniform decline but a trajectory shaped jointly by age and sex. Using continuous high-dimensional immunophenotyping, we show that aging T cells accumulate a senescent signature of CD28 loss and CD57 gain, and that males reach an inverted CD4:CD8 ratio ea...

Acute effects of the 1-minute sit-to-stand test (STST) on immune-metabolic stress indices

Abstract Characterizing the non-pathological, exercise-induced immune-metabolic stress regulation is important for understanding physiological adaptations and distinguishing them from maladaptive responses. Because such responses are mostly studied with extensive, resource-intens...