Isfahan University of Medical Sciences

How age and sex interaction is associated with immune aging with implications for vaccines and age-related autoimmunity

Immunosenescence is not a uniform decline but a trajectory shaped jointly by age and sex. Using continuous high-dimensional immunophenotyping, we show that aging T cells accumulate a senescent signature of CD28 loss and CD57 gain, and that males reach an inverted CD4:CD8 ratio ea...

The effects of royal jelly consumption on glycemia indices, lipid profile, and blood pressure in patients with acute ischemic stroke: a randomized, triple-blind trial

Abstract Aims The effects of royal jelly (RJ) on cardiometabolic risk factors in patients with acute ischemic stroke have not been previously reported from this trial. Therefore, we conducted a secondary analysis to investigate the effects of RJ consumption on glycemic indices, l...

The effect of a self-management training based on the 5As model on the sexual satisfaction of Iranian women: A randomized clinical trial

Sexual satisfaction is associated with sexual health and overall quality of life. This study aimed to determine the effect of self-management training based on the 5As model on the sexual satisfaction of Iranian women. This randomized clinical trial enrolled 82 women of reproduct...

Policy options for strengthening health technology assessment in Iran

Abstract Since health technology-related issues pose ongoing challenges for health systems, ensuring proper Health Technology Assessment (HTA) and its efficient and effective use for health care is essential. After more than a decade since the start of this system in the Iranian...

Incidence and clinical characteristics of amyotrophic lateral sclerosis during the post-COVID-19 Period: a population-based study from Isfahan, Iran

AIMS: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder. Understanding the underlying causes would help further studies on the pathogenesis and treatments. Recent interest has emerged in evaluating whether the COVID-19 pandemic and vaccination have a...

Accuracy of Rome IV questionnaire: a population-based study on diagnostic definitions and clinical validity

Rome IV questionnaire is widely used for diagnosing disorders of gut-brain interaction (DGBIs), but was developed in Western populations and may not generalize to other regions. This study aimed to validate the Persian version of this questionnaire and develop population-adapted...

PPE-Associated Skin Lesions Among ICU Healthcare Workers: Clinical Characteristics and Anatomical Distribution

Background: Personal protective equipment (PPE) is essential in intensive care units, especially when caring for patients with severe respiratory infections. At the same time, prolonged use of respirators, gloves, gowns, and face shields, together with frequent hand hygiene, can...

The utility of trehalose and niclosamide in modulating autophagy to inhibit Leishmania major infection in macrophage cells in vitro

Leishmaniasis is classified as a neglected tropical disease that the available anti-leishmanial medications are limited, often accompanied by side effects, high costs, and the necessity for prolonged treatment. Factors such as the diversity of species, drug resistance of the para...

Cognitive performance evaluation under exposure to heat and light color temperature: a bayesian network modeling approach in laboratory conditions

Indoor environmental quality significantly affects cognitive performance in educational and occupational settings. While the effects of ambient temperature and correlated color temperature (CCT) have been independently investigated, their mixed effect remains unclear. This experi...

Survival and biological and technical complications of veneered zirconia-ceramic versus metal-ceramic restorations: a systematic review and meta-analysis

This systematic review and meta-analysis aimed to critically assess and compare the survival rates and the spectrum of biological and technical complications associated with veneered zirconia-ceramic versus metal-ceramic restorations. By synthesizing evidence from randomized clin...

Expanded newborn screening for inborn errors of metabolism in Isfahan Province: the first two-year report from Central Iran

Abstract Background Inborn errors of metabolism cause significant infant morbidity and mortality. Birth prevalence is elevated in the Eastern Mediterranean region, influenced by consanguinity. This study presents the first findings of an expanded newborn screening program for IEM...

Comparative effects of glucagon-like peptide-1-based regimens on peripheral arterial and limb events in type 2 diabetes: a network meta-analysis of randomized trials

Peripheral artery disease (PAD) is a disabling condition in patients with type 2 diabetes mellitus (T2DM), yet lower-extremity outcomes are rarely prespecified in trials of GLP-1-based therapies. We compared individual GLP-1-based regimens for PAD-related vascular and limb events...

Development and psychometric validation of substance abuse prevention questionnaire based on the multi-theory model: construct validity and reliability

Substance abuse is one of the major social challenges worldwide. To address this issue, health promotion specialists are striving to overcome the limitations of existing health education models in promoting unhealthy behaviors. The relatively new Multi-Theory Model (MTM) has been...

Epidemiology and prevalence patterns of head lice infestation in Isfahan Province, central Iran based on a surveillance study (2017–2024)

This study aimed to describe the demographic, temporal, spatial, and treatment-related epidemiology of head lice ( Pediculosis capitis ) infestation in Isfahan Province, central Iran, using population-based surveillance data. A retrospective population-based analysis was conducte...

Silent allies: non-living microbes shaping the future of cardiometabolic health

Background Metabolic syndrome and its components constitute significant global health challenges, and growing evidence links their development to gut microbiota disturbances and altered microbial metabolites. Postbiotics have emerged as promising alternatives to traditional probi...

Mechanical stability of endotracheal tube fixation: a performance comparison between two tube holders and a conventional method

Accidental extubation remains a significant clinical concern in airway management, particularly in emergency and anesthetic settings. While commercial tube holders have shown improved fixation stability over adhesive tape, cost and availability limit their use in many healthcare...