Jena University Hospital

Prognosis of acute symptomatic seizures and impact of prolonged treatment with anti‐seizure medication

Abstract Objectives Acute symptomatic epileptic seizures (ASySs) occur in temporal proximity to acute brain insults. Given their low risk of subsequent unprovoked seizures, current guidelines recommend either no treatment with anti‐seizure medication (ASM) or early discontinuatio...

Marfan Syndrome versus Loeys–Dietz Syndrome after Aortic Surgery: A Systematic Review and Meta-analysis of Reconstructed Time-to-Event Data

Abstract Marfan syndrome (MFS) and Loeys–Dietz syndrome (LDS) are hereditary connective tissue diseases, both characterized by aortic root and vessel involvement with an increased risk of aneurysms and dissections. Despite advances in surgical techniques and improved postoperativ...

Development and Nationwide Multicentre Evaluation of Guideline-Grounded Large Language Model Chatbots to Support Patient Self-Management and Education in Rheumatology

Patients with rheumatic diseases have persistent information needs that are not fully addressed in routine care. We developed and evaluated guideline-grounded, large language model (LLM) chatbots to support patient self-management and education in rheumatology.Ten disease-specifi...

OsteoCHAT: real-world patient evaluation and benchmarking of a guideline-grounded osteoporosis chatbot

Patients with osteoporosis have information needs that routine care inconsistently addresses. In this multicenter real-world evaluation, the LLM-based, guideline-grounded chatbot OsteoCHAT showed high participant acceptability and achieved expert-rated answer quality comparable t...

Two cases of an imatinib-sensitive PRKG2::PDGFRA-positive chronic myeloid neoplasm with basophilia

The clinical and morphological phenotype of myeloid/lymphoid neoplasms with tyrosine kinase (TK) gene fusions (MLN-TK) is influenced by both the TK and the partner gene [ 1 ]. Here, we report on two patients with an initial diagnosis of a chronic myeloid neoplasm with prominent b...

Diagnosing autoimmune encephalitis in psychiatry: clinical recommendations and unresolved challenges from the GENERATE network

Psychiatric syndromes can be caused by underlying autoimmune encephalitis (AE). This represents a diagnostic challenge at the interface of psychiatry and neurology. While AE mostly manifests with a combined, complex neuropsychiatric syndrome, some patients with AE may (initially)...

Repetitive Peripheral Magnetic Stimulation as an Approach to Peripherally Stimulate the Lesioned Brain

Repetitive peripheral magnetic stimulation (rPMS) is a promising neurorehabilitative technique that aims to enhance motor recovery following stroke. rPMS induces non-invasive, pain-free muscle contractions through peripheral magnetic fields and may promote central neuroplasticity...

The German S3-level guideline for the diagnosis and management of rare dental disorders

Abstract Objectives The aim of this German S3-level guideline project was to develop evidence-based recommendations to support professionals in the diagnosis and management of individuals with rare dental disorders. The research question was which form of dental care should be pa...

Preparing surgery for Generation Z - Motivation and protective factors for pursuing a surgical career among medical students and early-career physicians: a cross-sectional study

Abstract Background Surgery is facing a substantial shortage of young professionals. In particular, it has become increasingly difficult to attract medical students, especially women, to pursue a surgical career, although women currently represent the majority of medical students...

Subclassification of Vieth stage 4 in MRI of the proximal tibial epiphysis: a pilot study for forensic age estimation

Abstract The MRI-based staging system introduced by Vieth et al. has been successfully validated for assessment of the proximal tibial epiphysis. Our previous validation study suggested that additional information regarding completion of the 16th or 18th year of life might be obt...

Expanding the genotypic and phenotypic spectrum of PGAP1 deficiency: clinical and functional insights from 15 patients

Glycosylphosphatidylinositol-anchored proteins (GPI-APs) are essential for neuronal development, synaptic organization and signaling. Defects in GPI-anchor biosynthesis or remodeling cause rare neurodevelopmental disorders, including post-GPI attachment to proteins 1 (PGAP1) defi...

Molecular divergence and genomic composition of B chromosomes in the fish Cyphocharax modestus (Characiformes, Curimatidae)

Abstract B chromosomes are supernumerary elements that evolve from standard A chromosomes and are primarily composed of repetitive DNAs, yet their origin, diversification, and molecular composition remain poorly understood in most vertebrates. We investigated two allopatric popul...

Views on Ageing and Loneliness in Older Patients Undergoing Geriatric Treatment

Background/Objectives: Loneliness is a clinically relevant psychosocial factor in later life and has been associated with adverse mental, cognitive, and physical health outcomes. Views on ageing may shape social engagement, coping, and perceived belonging, but evidence from geria...

Large-scale benchmarking of prokaryotic annotation tools across thousands of species

Abstract Background Genome annotation is an important step in deriving functional meaning from prokaryotic sequencing data, yet systematic evaluations guiding tool selection are lacking. We present the first large-scale investigation of four prominent open-source annotation tools...

Controlling Grain Growth in Powder Bed Fusion of Yttria‐Stabilized Zirconia Using Femtosecond Lasers: Challenges and Methodological Insights

This study demonstrates binder‐free laser powder bed fusion (PBF‐LB) of 8 mol% yttria‐stabilized zirconia (8YSZ) using a femtosecond laser and a triangular scan strategy that controls heat accumulation by varying scan‐vector length. Laser power (31–52 W), scan speed (100–500 mm s...

Treatment of Congenital Cytomegalovirus Beyond the Neonatal Period: A Single‐Arm Meta‐Analysis

ABSTRACT Objective To evaluate hearing outcomes in postneonatal treatment of congenital cytomegalovirus (cCMV) infection and assess the effect of treatment initiated after the first month of life. Data Sources PubMed, Embase, Web of Science, and Cochrane Library were systematical...

The role of general practitioners in German cancer care: a scoping review

Abstract Background General practitioners (GPs) play an important role in the care of patients with cancer across the entire cancer continuum, from diagnosis to palliative care. Despite their broad range of responsibilities, structures to facilitate the systematic involvement of...

A Ni(II) PNP pincer complex immobilized on SBA-15 as catalyst for the 4-nitrophenol hydrogenation

Abstract The Ni(II) complex [NiCl(bda)]+ containing the aliphatic PNP pincer ligand bis((2-diphenylphosphino)ethyl)amine (bda) was covalently immobilized on the mesoporous silica SBA-15. SBA-15 was functionalized with (3-chloropropyl)triethoxysilane as an anchoring agent, which w...

Timing of PCI in Patients Undergoing Transcatheter Aortic-Valve Implantation

BackgroundApproximately one half of patients undergoing transcatheter aortic-valve implantation (TAVI) have concomitant coronary artery disease. Although percutaneous coronary intervention (PCI) is often performed before TAVI, the preferred treatment strategy has not been establi...

Longitudinal changes in bioelectrical impedance–derived body composition after sleeve gastrectomy in patients with class III obesity

Abstract Purpose Weight loss after bariatric surgery is commonly reported using anthropometric parameters; however, these measures do not distinguish between changes in fat mass, lean tissue, and body water. Bioelectrical impedance analysis (BIA) enables a more detailed assessmen...