Jena University Hospital

How age and sex interaction is associated with immune aging with implications for vaccines and age-related autoimmunity

Immunosenescence is not a uniform decline but a trajectory shaped jointly by age and sex. Using continuous high-dimensional immunophenotyping, we show that aging T cells accumulate a senescent signature of CD28 loss and CD57 gain, and that males reach an inverted CD4:CD8 ratio ea...

4CzIPN Photosensitizes the Cobaloxime‐Catalyzed Light‐Driven Hydrogen Evolution Reaction

TADF compounds have found great application as photocatalyst in recent years. Their use as photosensitizers (PS), however, is still limited although they have a huge potential as abundant alternatives for traditional noble metal-based PSs, such as [Ru(bpy)3]2+. We herein investig...

Antibacterial characteristics of black currant fruit extracts

<title>Abstract</title> <bold>Background</bold> : Our group previously reported from high bactericidal potential of berry juices, especially from blackcurrant fruits. The present study observed different fractions from blackcurrant fruits (all-fruit juice: AFJ, squeezed juice: SJ...

Diagnostic Performance of Preoperative Multiparametric MRI for Local and Nodal Staging in Penile Cancer: A Histopathology-Correlated Single-Centre Study

Background/Objectives: Histopathology-correlated evidence for preoperative magnetic resonance imaging (MRI) in penile cancer remains limited. We evaluated multiparametric MRI with artificially induced erection for local and nodal staging in surgically treated penile cancer. Metho...

Acute effects of the 1-minute sit-to-stand test (STST) on immune-metabolic stress indices

Abstract Characterizing the non-pathological, exercise-induced immune-metabolic stress regulation is important for understanding physiological adaptations and distinguishing them from maladaptive responses. Because such responses are mostly studied with extensive, resource-intens...

Subgroup variations in effectiveness of femoropopliteal sirolimus versus paclitaxel-coated balloon angioplasty: post hoc results of the randomised SIRONA trial

INTRODUCTION: The randomised SIRONA trial showed that sirolimus-coated balloon (SCB) angioplasty was non-inferior to paclitaxel-coated balloon angioplasty (PCB) regarding femoropopliteal primary patency. There was no difference in clinically driven target lesion revascularisation...

MRI Tract‐Based Quantitative Susceptibility Mapping of Limbic White Matter Alterations in Preeclampsia

BACKGROUND: Preeclampsia is associated with long-term cerebrovascular and cognitive risk, but tract-level white matter (WM) involvement remains incompletely characterized. PURPOSE: To investigate whether preeclampsia is associated with tract-level WM susceptibility alterations on...

Effect of distal screw number on axial deformation and fragment-specific stability in AO/OTA 2R3 C2.1 distal radius fractures

PURPOSE: To investigate the biomechanical influence of distal screw number in palmar plate fixation of unstable intra-articular distal radius fractures with radiodorsal metaphyseal comminution. METHODS: Nine matched pairs of cryopreserved human radii were prepared using a standar...

Serial dual-wavelength illumination for retinal vessel oximetry using a conventional fundus camera: a proof-of-concept study

Abstract Purpose Retinal vessel oximetry requires fundus images at two wavelengths with different hemoglobin absorption characteristics. Simultaneous acquisition using one-chip color cameras may be affected by incomplete spectral separation of detector channels, whereas multi-chi...

DECIDER-2: Prospective randomized multicenter phase III trial of decitabine and venetoclax administered in combination with all-trans retinoic acid or placebo in patients with acute myeloid leukemia who are ineligible for induction chemotherapy

Abstract Background Acute myeloid leukemia (AML) is predominantly a disease of older patients with a poor long-term survival. Approval of the combination of venetoclax (VEN) with azacitidine (AZA) or decitabine (DAC) in the European Union in 2021 for the treatment of patients wit...

Accelerating Translation of NK Cell Therapies to the Clinic: A European Perspective

Adoptive immunotherapies have emerged as a promising strategy in the treatment of hematological malignancies. To date, seven chimeric antigen receptor (CAR)-T cell products have obtained market authorization in Europe for B-cell malignancies, where they have revolutionized treatm...

Real-world data on patient-reported outcomes and potential factors associated with pain after thyroid/parathyroid surgery: a prospective QUIPS registry analysis of a large cohort – sparking new pain management concepts

Abstract Background Although thyroid and parathyroid surgeries are common elective procedures in Germany, postoperative pain management remains unstandardized. This prospective study sought to quantify postoperative pain intensity after thyroid and parathyroid surgery and to exam...