Carsten Watzl

Acute viral respiratory infections are not associated with an increased IMMune Age indeX (IMMAX) four weeks after infection: a prospective observational cohort study

Abstract Background The factors that determine how quickly immunosenescence occurs in individuals are not yet fully understood. Viral infections throughout one’s life span are suggested to be a relevant modulator. Latent chronic infections, such as CMV or EBV, occupy immune space...

How age and sex interaction is associated with immune aging with implications for vaccines and age-related autoimmunity

Immunosenescence is not a uniform decline but a trajectory shaped jointly by age and sex. Using continuous high-dimensional immunophenotyping, we show that aging T cells accumulate a senescent signature of CD28 loss and CD57 gain, and that males reach an inverted CD4:CD8 ratio ea...