Biochemistry, Genetics and Molecular Biology · Structural Biology
Researchers created closely alternating nickel and nickel molybdate domains less than a nanometer across. The catalyst reached 2 A per square centimetre at 1.62 volts and operated stably for more than 2,200 hours under the reported testing conditions.
Researchers have determined how two DNA repair proteins, polymerase lambda and PNKP, work together in a complex that brings broken DNA ends into close contact. The findings suggest that this large repair complex can process several types of damaged DNA ends so they can be joined.
Researchers have identified where the drug dantrolene binds on RyR1, the calcium-release channel involved in malignant hyperthermia. The findings show that dantrolene works together with ATP or ADP to trigger a structural change linked to closing the channel.
A study using cryogenic electron microscopy of cell extracts found that the protein eEF2 was attached to more than 95% of hibernating ribosomes. The protein also unexpectedly bound to isolated 60S subunits, while other proteins occupied different ribosome sites.
