Biochemistry, Genetics and Molecular Biology · Molecular Biology
Researchers used a porous silica film to increase the amount of DNA produced on an electrochemical chip. The platform synthesized 121-letter DNA strands and encoded, wrote and recovered digital information with error correction.
A study found that controlling how antibodies face on both the test particles and the test strip improved the sensitivity of lateral flow tests. The approach detected two cancer markers at once with little cross-reactivity and was checked against a hospital reference method in 28 serum samples.
Researchers have reviewed genetic circuits that use light, ultrasound or magnetic fields to control gene activity and cell functions. The analysis compares how these systems sense outside signals, process them inside cells and produce genetic responses, while outlining the tests needed for potential medical use.
Researchers developed a portable hydrogel sensor that changes color when PFAS interfere with a peroxide-driven chemical reaction. The sensor distinguished PFAS groups by their chemical endings and quantified PFOA at a reported detection limit of 0.12 micrograms per milliliter.
Researchers have determined how two DNA repair proteins, polymerase lambda and PNKP, work together in a complex that brings broken DNA ends into close contact. The findings suggest that this large repair complex can process several types of damaged DNA ends so they can be joined.
A programmable DNA device punctured artificial membranes, delivered attached molecular cargo and then retracted to promote resealing. Researchers also used it to control biochemical reactions in cell-sized environments, but the study does not report tests in living organisms.
