Zhengzhou University

The crystal structure of 10 H -phenothiazine-10-carbonyl chloride C 13 H 8 NOSCl

Abstract C 13 H 8 NOSCl, monoclinic, I 2/ a (no. 15), a = 12.7689(2) Å, b = 8.9005(1) Å, c = 20.9192(3) Å, β = 103.333(2)° V = 2313.35(6) Å 3 , Z = 8, R gt ( F ) = 0.0376, w R ref ( F 2 ) = 0.1040, T = 294.9(3) K.

p38β-mediated BiP phosphorylation drives stemness and chemoresistance by suppressing UPR activation in hepatocellular carcinoma

Abstract Tumor-initiating cells (TICs) promote tumor initiation and therapy resistance, yet the kinase regulators that sustain TICs remain incompletely defined. Here, we identify the stress kinase p38β (MAPK11) supports TIC maintenance and drug resistance in hepatocellular carcin...

Deformation behavior of plastic-metal hybrid components for optical image stabilization: from injection molding to thermal processing

Abstract Micro-structured plastic-metal hybrid (MPMH) components fabricated by insert injection molding are widely used in miniaturized optical modules because of their structural integration and multifunctional performance. However, the multi-stage processes from injection moldi...

Spatiotemporal-switchable 2D NIR-II single-atom nanozyme for single-cell–level surgical navigation and glioblastoma phototherapy

Single-cell–level resolution tumor therapy represents an advanced strategy against glioblastoma but lacks suitable theranostic agents. Here, we developed a spatiotemporal-switchable, two-dimensional (2D), bismuthene-based second near-infrared window (NIR-II) nanozyme. In this pla...

Understanding Transversely Polarized Quarks Inside Longitudinally Polarized Nucleons

We review the current understanding of transversely polarized quarks inside longitudinally polarized nucleons from the perspective of the longi-transversity distribution function and transverse-momentum-dependent (TMD) factorization. Employing the recently developed TMD evolution...

Antioxidant nanozymes for regenerative medicine: mechanisms, design, and applications in tissue repair

Natural antioxidant enzymes play a central role in regulating oxidative stress within living organisms. During tissue repair following injury, these enzymes act synergistically to scavenge excess reactive oxygen species and maintain cellular redox homeostasis, thereby supporting...

Au Single‐Atom Interlayer Bridge Promotes Cross‐Layer Charge Transport and Intrinsic Catalytic Dual‐Sites Activation for Efficient CO 2 Photoreduction

ABSTRACT Layered photocatalysts are attractive for artificial photosynthesis, but their performance is often limited by inefficient charge transport across interlayer gaps and sluggish surface reaction kinetics. Herein, we propose a single‐atom interlayer bridge strategy by intro...

Interaction ofFood-Derived Bitter Peptides with hTAS2R4:Recognition and Activation Mechanisms Revealed by Docking and Mutagenesis

Abstract Bitter peptides (BPs) have a wide range of applications in the food and pharmaceutical industries. This study identified four food-derived BPs (TPLVDR, VLY, LEEL, and FYL) as novel agonists of the human bitter taste receptor hTAS2R4, using a rapid cell-based screening ap...

Combined administration of fructooligosaccharides and Clostridium butyricum attenuates bowel cleansing-induced dysbiosis and safeguards mucosal defense in a murine model

Bowel preparation with polyethylene glycol electrolyte solution (PEG-ELS) is indispensable for gastrointestinal endoscopy and related procedures. However, it disrupts gut microbial homeostasis and increases host vulnerability to ensuing infection. In a murine model, we optimized...

Research progress on multi-mechanism analysis and protection strategies of ovarian aging and fertility decline

Age-related fertility decline is an increasingly important challenge in reproductive medicine, driven largely by progressive ovarian aging. The aging ovary undergoes functional deterioration characterized by reduced ovarian reserve and declining oocyte quality, ultimately limitin...

The influence of self-supporting personality on social anxiety in college students: the serial-mediating roles of attention bias and social problem-solving orientation

Social anxiety is highly prevalent among college students and is associated with impaired academic functioning and long-term social maladjustment. Although prior research has documented the adaptive value of self-supporting personality, the specific cognitive-behavioral mechanism...

Physics‐Informed Neural Networks for Flexoelectric Boundary Value Problems: A Reformulated Architecture for High‐ and Mixed‐Order Electromechanically Coupled Systems

ABSTRACT Flexoelectricity denotes a universal electromechanical coupling in dielectric materials, whereby strain gradients break local inversion symmetry and induce electric polarization. The resulting boundary value problem (BVP) is governed by a coupled multi‐physics system of...

Tranexamic acid in primary total knee arthroplasty: a systematic review and meta-analysis of blood loss, transfusion, and deep vein thrombosis

Tranexamic acid (TXA) has been widely used in primary total knee arthroplasty (TKA) to reduce perioperative blood loss, but the pooled evidence regarding blood loss, transfusion, and deep vein thrombosis (DVT) remains to be further clarified. The purpose of this meta-analysis was...

Switchable 2 e − /4 e − ORR Pathway Directed by Spin‐State Engineering for High‐Rate H 2 O 2 Production

ABSTRACT Precise control of the 2 e − /4 e − oxygen reduction reaction (ORR) pathway is essential for directing H 2 O 2 production toward high efficiency and scalability. However, rational regulation of the active site's electronic spin‐states to dictate selectivity remains a fun...