Zhengzhou University

Fuzuloparib in combination with apatinib versus fuzuloparib alone for recurrent ovarian cancer: a randomized, open-label, phase 2 trial

A randomized, open-label, phase 2 trial assessed fuzuloparib (a PARP inhibitor) plus apatinib (a vascular endothelial growth factor receptor [VEGFR] inhibitor) versus fuzuloparib alone in patients with recurrent ovarian cancer (ROC). Patients with ROC who had failed ≥ 2 lines of...

Plant-based diet and risk of cognitive decline among older adults: a community-based prospective cohort study

Background: Diet serves as a modifiable risk factor for cognitive decline, yet evidence on plant-based diets and cognitive ageing remains limited. We examined the association between plant-based diets and cognitive decline.Methods: A total of 6,721 participants from the Chinese L...

A One-Pot Reverse Transcriptase-Mediated, Pre-amplification-Free CRISPR/Cas12a Assay for Ultrasensitive Nucleic Acid Detection

Abstract CRISPR/Cas12a holds great promise for biosensing and diagnostics, but conventional methods suffer from low catalytic efficiency, high background, and reliance on pre-amplification. Direct detection of structured RNAs also remains challenging. Herein, we report the develo...

Discovery ofa Potent APOBEC3B Inhibitor to AugmentAntitumor Immunity and Reduce Inflammatory Toxicity

Abstract APOBEC3B (A3B), a key driver of cancer mutagenesis, has emerged as a promising therapeutic target to be ablated to enhance antitumor immunity while reducing intestinal inflammation. Starting from SMC247 (3, 5-diiodotyrosine), a kelp-derived natural product, we identified...

Structural Designof AlGaN Deep-Ultraviolet Laserat Wavelength 266.3 nm with Graded Electron Blocking Layer and CompositeQuantum Wells/Barriers

Abstract Deep-ultraviolet laser diodes (DUV LDs) are developing as vigorous light sources for sterilization, lithography, purification, and biochemical sensing. However, the development of high-performance deep-UV laser diodes is still limited by poor hole injection, which comes...

The SF3b complex in cancer: structural basis, molecular mechanisms, and therapeutic opportunities

Aberrant alternative splicing is increasingly recognized as a fundamental driver of cancer initiation and progression. The splicing factor 3b (SF3b) complex, an essential component of the U2 small nuclear ribonucleoprotein (snRNP), plays a pivotal role in branch point sequence (B...

Isotropic-carrier-transport perovskite single crystal enables high-photoresponsivity solar-blind photodetectors for selective flame monitoring

Low-dimensional halide perovskites are promising candidates for solar-blind ultraviolet photodetectors. However, simultaneously achieving high photoresponsivity and low dark current remains challenging, due to the restricted transport and collection of photogenerated carriers cau...

Baicalin-Ternary LDH-Modified Magnesium Alloy with Anti-Corrosion and pH-Responsive Controlled Release, Near-Infrared-Enhanced Catalytic Property

Aiming at the rapid corrosion of degradable magnesium alloys in physiological environments and the insufficient long-term protection of single plasma electrolytic oxidation (PEO) coatings, Mg-Mn-Fe layered double hydroxide (LDH) and baicalin (BA)-loaded LDH/BA composite coatings...

In-Plane Shear Behavior of Masonry Walls Strengthened with High-Ductility Concrete and Steel Connectors

This study investigates the influence of high-ductility concrete (HDC) strengthening configurations and steel connector positions on the in-plane shear performance of masonry walls in a retrofit scenario where the external masonry facade is retained while the original masonry wal...

StructuralDiversity and Multicenter Bonding in Beryllium–OsmiumIntermetallic Compounds

Abstract Beryllium intermetallic compounds (beryllides) have attracted considerable interest for applications relevant to nuclear systems, refractory materials, and aerospace systems due to their exceptional physical properties. In this work, crystal structures of osmium beryllid...

Solid‐Phase Engineered Metal‐Free Carbonized Polymer Dots With Auto‐Generated Rigid Amorphous Network Enabled High‐Temperature Liquid‐Phase Phosphorescence

While organic phosphorescent materials hold immense promise, their application is severely hampered by limited emission tunability, short lifetimes, and environmental instability. Herein, we report a facile solid-phase engineering strategy to achieve the large-scale synthesis of...

Stress-State-Dependent Reinforcement of Cement-Stabilized Soil Using Waste Brick Powder and Glass Fiber

Cement-stabilized soil is widely used for ground improvement but suffers from brittleness and low tensile strength. This study investigates combined modification of cement-stabilized soil with waste brick powder (WBP, 5%) and glass fiber (GF, 0–2.0%) to enhance mechanical perform...

Analysing Lost Highway as a Non-deterministic Narrative Structure: Initiating Déjà Vu-like Recognition to Establish Non-causal Linkage

This article examines how repetition produces déjà vu-like recognition in non-deterministic narrative cinema. Focusing on David Lynch’s Lost Highway (1997), it argues that the film’s repetitions do not lead to conventional repetition–resolution, but instead organise an entangled...

Influence of Composite Mineral Admixtures and Expansive Agent on the Mechanical Properties, Durability and Microstructure of Cementitious Materials

To improve volume stability and durability of cementitious materials, a composite mineral admixture including ground granulated blast furnace slag, fly ash and silica fume was incorporated at a fixed 12% replacement ratio together with varying dosages of an expansive agent (EA)....

Osimertinib With or Without Chemotherapy in Advanced Non–Small Cell Lung Cancer With EGFR and Concurrent TP53 Mutations

Importance: Combination therapy has emerged as a promising therapeutic approach for patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). However, its clinical benefit-risk profile remains a focus of ongoing debate. Identifying patients...

Leakage Identification in Water Distribution Networks Based on Physics-Based Joint Inversion and ExtraTrees Candidate Re-Ranking

Leakage identification in water distribution networks must estimate leak locations and magnitudes under demand fluctuations, similar adjacent-node responses, and superimposed multiple-leak signals. This study combines physics-based joint inversion with ExtraTrees candidate re-ran...

Treatment of Acute Ischemic Stroke with Intravenous Urokinase (TASK-UK): Protocol for a Multicenter, Prospective, Real-World Study

Intravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA) and urokinase (UK) are both recommended for acute ischemic stroke (AIS) in China. Compared with rt-PA, UK is less expensive and more widely available in clinical practice. The Treatment of Acute Ischem...

Charge-Transfer Engineering in 0D/3D Rare-Earth Halide Heterostructures Enables Tunable and Efficient White Light-Emitting Diodes

Abstract Lead-free rare-earth metal halides hold great promise for solid-state white-light LEDs, yet efficient and spectrally tunable white emission remains challenging. Herein, we adopt an in situ alloying strategy with Ag+ ions to design and synthesize a 0D/3D (Cs3LuCl6/Cs2AgLu...

Biobased Fibrous Films Enabling Synergistic Thermal Conduction and Radiative Cooling for Personal Thermal Management

Abstract Personal thermal management materials are increasingly in demand under intensifying outdoor heat exposure and global warming. However, simultaneously achieving efficient radiative cooling, rapid thermal conduction, mechanical flexibility, and sustainability within a simp...

Joint effects and mediating mechanisms of body roundness index and biological aging on the risk of incident cardiovascular disease: a nationally representative prospective cohort study

Body roundness index (BRI) and biological aging are critical drivers of cardiovascular disease (CVD). However, their joint pathogenic effects and underlying mechanisms in the development of CVD remain elusive. This study aims to investigate the independent and joint effects of BR...