Trifluoroallyl Sulfonium Salts: Reagents for Highly Regioselective Trifluoroallylation

Abstract

Abstract We report the design, synthesis, and application of novel bench-stable and scalable trifluoroallylating reagents, trifluoroallyl sulfonium salts (TFASs), which readily react with a series of organozinc reagents under copper catalysis to afford allylic trifluoromethyl-terminal alkenes with high efficiency and regioselectivity. Subsequent transformations of the resulting products further demonstrate the synthetic utility of these reagents.