Zhengzhou University

Lactylation-regulated METTL3-mediated cholesterol metabolic reprogramming via FDFT1 facilitates macrophage polarization in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) exhibits limited clinical response to immunotherapy, highlighting the pressing need for novel strategies targeting its immunosuppressive microenvironment. While metabolic reprogramming and epigenetic alterations contribute to malignancy, the role of...

Network analysis of smartphone addiction, attentional control, and learning adaptation among nursing undergraduates

In the digital learning environment, learning adaptation and attentional control have been shown to be important factors associated with academic success among nursing undergraduates. Smartphone addiction has been associated with impaired attentional control and poorer learning o...

Recent Advances in Biomimetic Hydrogels for Bioelectronics and Human–Machine Interactions

Biomimetic hydrogels have emerged as versatile bioelectronic interface materials for bioelectronics and human–machine interfaces (HMIs), enabling mechanically compliant and multifunctional interactions between electronic devices and biological tissues. Inspired by the structures...

Motivational orientation and influencing factors of older adults with chronic obstructive pulmonary disease in community dwellings: a latent profile analysis

Chronic obstructive pulmonary disease (COPD) poses a serious threat to older adults’ health. Promoting the adoption of health behaviors among community-dwelling patients is essential for improving prognosis, with motivational orientation serving as a key determinant of health beh...

A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease

ABSTRACT Inflammatory bowel disease (IBD) is a chronic condition caused by altered cytokine signaling, maladaptive immunity, dysbiosis, and intestinal barrier dysfunction. Patients with IBD receive therapy to correct these imbalances and achieve remission. However, most patients...

Secondary prevention of cancer therapy-induced thrombocytopenia with hetrombopag in breast cancer: a multicenter, randomized, exploratory phase II trial

Abstract Background: Cancer therapy-induced thrombocytopenia (CTIT) is a common complication of anti-tumor therapy, leading to treatment delays or interruptions, increased bleeding risk and compromised outcomes. In the present study, we aimed to evaluate the efficacy and safety o...

Recent Progress in the Synthesis of Sulfonylmethyl Compounds Using Diverse Sulfonylmethylating Reagents

Sulfonylmethyl motif is widely present in many organic compounds and has shown important application in pharmaceutical chemistry, organic synthesis, and materials science. In recent years, considerable attention has been devoted to the development of efficient methods for constru...

Biomedical Materials and Fabrication Methods for Construction of In Vitro Neurovascular Unit Models

In vitro neurovascular unit (NVU) models are essential for reproducing blood–brain barrier (BBB) transport and neurovascular cell interactions. However, the literature remains fragmented: biomaterial chemistry, fabrication parameters and organ-on-a-chip architecture are commonly...

Social support and exercise persistence among chinese university students: integrating social ecological and self-determination theories

Under the macro-guidance of the "Healthy China 2030" strategy, promoting students’ physical health and cultivating lifelong sports habits has become a long-term core issue and important strategic goal of China’s educational policies. This study examined whether social support was...

Direct Molecular Editing of Complex Molecules for Drug Discovery

ABSTRACT Innovative synthetic methods that allow for the direct, efficient modification of complex lead compounds are essential for accelerating drug development. In particular, molecular editing enables the precise, late‐stage diversification of privileged scaffolds, streamlinin...

Pulmonary embolism in lung cancer: a retrospective exploratory study

Lung cancer is associated with a high risk of venous thromboembolism, and pulmonary embolism (PE) is a critical complication. The synchronous diagnosis of PE at the initial presentation of lung cancer presents diagnostic challenges and affects management. The predictive factors f...

Simulation of Discharge Evolution in the Main Streams of Large Rivers Using a Deep Learning Model: A Case Study of the Yellow River, China

Abstract Simulating river discharge evolution is fundamental to water resources management in large river basins. Nevertheless, human activities such as intensive water abstraction, reservoir operation, and other anthropogenic interventions have rendered the patterns of river dis...

Nicotinamide Metabolism Constrains Memory CD8 + T Cell Formation Through a Putative HS1BP3‐SIRT1‐FOXO3‐BCL6 Axis

ABSTRACT Memory T cells exhibit long‐term persistence, a defining feature that underpins durable clinical responses to adoptive immunotherapies. The mechanisms that integrate metabolic cues with transcriptional control of memory fate remain undetermined. Here, we identify HS1‐bin...

Hippocampal Local Field Potentials Encode Continuous Flight Speed in Homing Pigeons via Complementary Gamma and Theta Signatures

Although the role of the mammalian hippocampus in representing locomotor speed has been widely investigated, how the avian hippocampus represents continuous flight speed under free-flight conditions in the outdoor environment remains unclear. In this study, we used homing pigeons...

Low-Oxygen and Dense Mo10Cr Alloys Prepared via In-Situ Nanocarbon Deoxygenation and Two-Step Pressurization Hot Pressing

Hot pressing is a promising technique for fabricating high-density molybdenum (Mo) alloys; however, obtaining low oxygen content remains a significant challenge. In this study, Mo10Cr alloy billets were prepared by hot pressing with nanocarbon addition and a two-step pressurizati...

Policy Pathways for Coordinated CO2 and Air Pollutant Reductions in Urban Road Transport: A Case Study of Zhengzhou, China

Urban road transport policies must simultaneously address climate mitigation, local air quality, and the infrastructure requirements associated with vehicle electrification. However, these dimensions are rarely evaluated within a unified city-level framework. This study develops...

Multi-omics profiling reveals gene signatures and therapeutic targets in HER2-guided gastric cardia adenocarcinoma patients

Abstract Therapeutic targets for gastric cardia adenocarcinoma (GCA), particularly for HER2-negative patients, are lacking. Here, we conducted multi-omics profiling on 128 GCA patients using mass spectrometry, whole-exome sequencing, RNA-Seq, scRNA-Seq and spatial transcriptomics...

Entertainment Sedentary Time and Subjective Well-Being in College Students: A Moderation Model of Perceived Time Poverty

This study examined the association between entertainment sedentary time (EST) and subjective well-being (SWB) among Chinese college students and further explored the moderating role of perceived time poverty (PTP). A total of 1582 college students completed questionnaires assess...

Spin state and orbital engineering of cuprous oxide for efficient nitrate reduction

Abstract Electrocatalytic nitrate reduction provides a sustainable pathway for wastewater treatment and ammonia production, yet the complex multi‑electron transfer demands efficient catalysts to achieve both high selectivity and fast kinetics. Here we show that atomic substitutio...

Interface-shrunk regulated synthesis of asymmetric ultrafine mono-mesopore Nepenthes with tailored window

Asymmetric ultrafine mono-mesopore architectures with ultrasmall size, an open window, and unique physicochemical properties offer great opportunities in energy storage, yet their synthesis remains challenging. Inspired by the fast, unidirectional capture ability of Nepenthes, we...