Westlake University

scProtoTransformer: Scalable reference mapping across molecules, cells, and donors

Abstract The rapid accumulation of single-cell data has made it possible to comprehensively characterize biological systems at molecular, cellular, and donor levels. However, scalable reference mapping across different resolutions remains a major challenge in current research. He...

Dynamic Responses of Groundwater Flow and Salt Transport to Storm Surge Inundation in Unconfined Coastal Aquifers

Abstract Storm surges severely salinize coastal aquifers, yet post‐storm subsurface hydrodynamics remain poorly understood. We investigated surge inundation in unconfined tidal aquifers, revealing that subsurface flow recovers much faster than salinity distributions. Immediately...

Mitochondrial DNA mutation triggers early-onset intestinal epithelial cell dysfunction during acute colitis

Abstract Background Mitochondrial DNA (mtDNA) mutations cause multisystem disorders often involving gastrointestinal dysfunction. However, the mechanisms governing the selection against mutant mtDNA and the specific impact of pathogenic mtDNA mutations on intestinal epithelial ce...

Distinct regulation of Wnt signaling and EPZ5676 governs human UiPSM reprogramming via the CDX2/T/TBX6 core axis

An ideal in vitro system to study somitogenesis is induced presomitic mesoderm (UiPSM); the regulatory pathways of this system are not well understood. Here, integrated multi-omic and functional analyses were performed to elucidate the roles of Wnt signaling and EPZ5676 in UiPSM...

Mechanisms and Clinical Assessment of Fear of Disease Progression in Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a progressive, life-limiting neurodegenerative disease characterized primarily by motor dysfunction, although cognitive and behavioral impairment occurs in a substantial subset of patients. Progressive functional decline and prognostic uncer...

Gate-imprinted memory and light-induced erasure of superconductivity at KTaO3-based interfaces

Realizing non-volatile control of superconductivity is a key step toward integrating memory and quantum functionality in future information technologies. KTaO₃-based heterostructures uniquely host interfacial two-dimensional superconductivity and quantum paraelectric lattice back...

Enantioselective Convergent Synthesis of Heterohelicenes via Copper-Catalyzed Propargylic Annulation/Acid-Promoted Aromatization

Abstract Heterohelicenes combine helical chirality with tunable electronic properties, making them attractive for applications in chiral materials and optoelectronics. However, their enantioselective synthesis, particularly for five-membered heterohelicenes, remains a long-standi...

An explainable biomedical foundation model via large-scale concept-enhanced vision–language pretraining

Artificial intelligence for medical imaging is required to be accurate and interpretable to clinicians. However, current multimodal biomedical foundation models often prioritize performance over explainability. Here we present ConceptCLIP, an explainable biomedical foundation mod...

Accuracy assessment of Chinese large language models in psoriasis management: a multicenter expert evaluation study

Psoriasis patients in China face severe barriers to disease knowledge acquisition and limited access to medical resources, creating an urgent demand for reliable, evidence-based patient education tools. This multicenter expert evaluation study aimed to systematically assess the q...

Multidisciplinary diagnosis and treatment of lingual thyroid presenting as hematemesis

Rationale: Hematemesis is a common symptom of gastrointestinal disorders and is often associated with upper gastrointestinal issues. However, lingual thyroid, a rare ectopic thyroid condition, can also present with hematemesis, complicating diagnosis and increasing the risk of mi...

Influence of Isokinetic Muscle Strength Training Combined With Early Functional Exercise on Joint Function After Knee Cruciate Ligament Reconstruction

AIM: The purpose of this study was to evaluate and analyze the influence of isokinetic muscle strength training combined with early functional exercise on joint function after knee cruciate ligament reconstruction.METHODS: A total of 294 patients undergoing knee cruciate ligament...

Structural basis of fatty acid activation and transport by human FATP2

Fatty acid transport proteins (FATPs) are responsible for efficient uptake of fatty acids (FAs), essential biomolecules that play critical roles in development and growth. However, the lack of three-dimensional structures of FATPs has hindered our understanding of their mechanism...

Phosphoantigen-driven dissociation of butyrophilin oligomers activates γδ T cells

γδ T cells represent a promising avenue for cancer immunotherapy. The Vγ9Vδ2 T-cell receptor (TCR), which is expressed by the predominant subset of γδ T cells, responds to phosphoantigen (pAg)-engaged butyrophilins (BTNs) on various cancer cells. However, the molecular mechanism...

A gut microbiome‐lipid axis in early pregnancy is associated with metabolic dysregulation and diabetes risk

Abstract Gestational diabetes mellitus (GDM) reflects metabolic dysregulation that becomes clinically apparent during pregnancy and shares key pathophysiological features with broader forms of diabetes. Gut microbiome‐host metabolic interactions may contribute to this process, ye...

Consistency of urethroscopy vs. high-frequency ultrasound in diagnosing male urethral condyloma acuminatum

Abstract Objectives Urethral condyloma acuminatum(CA) is characterized by hidden growth, high treatment difficulty, high recurrence rate, and significant harm. Urethroscopy is a traditional method for examining male urethral CA. As a safe, non-invasive, highly reproducible, and c...

Computational Discovery of Novel Sulfide Lithium Superionic Conductors via a Structural‐Feature‐Constrained Generative Model

ABSTRACT Recent advances in generative models have opened new avenues for discovering novel materials with desired properties by steering generation toward property constraints. However, for properties that are scarce, inconsistent across different sources, or difficult to obtain...

Molecular characteristics and formation pathways of organosulfur compounds: a comparative field study across contrasting atmospheric environments

Abstract. Organosulfur compounds (OrgSs), especially organosulfates (OSs), are ubiquitous aerosol components. However, the spatial, seasonal, and day-night variations of OrgS formation in polluted atmospheres remain poorly understood. Here, we monitored particulate OrgSs at an ur...

Mitigating Stress‐Induced Nonphotoactive Phase Transition Through Sodium Sulfonate Engineering for Stable and Efficient Perovskite Solar Cells

ABSTRACT Formamidinium lead triiodide (FAPbI 3 ) perovskite solar cells (PSCs) have attracted significant attention due to their outstanding optoelectronic properties. However, their long‐term stability remains limited by lattice strain‐induced transition from the photoactive α‐p...

Chromium‐Catalyzed Stereodivergent Carbonyl Addition Dictated by Non‐Covalent Interactions

ABSTRACT Catalytic stereodivergent synthesis, which accesses the full complement of stereoisomers from a common precursor set, is a paramount objective in drug discovery. However, achieving this control via radical‐involved pathways remains a formidable frontier due to the transi...

Multi-ancestry conditional and joint analysis applied to GWAS summary statistics

Manc-COJO (Multi-Ancestry Conditional and Joint Analysis) is a C++ software package for identifying independent association signals from multi-ancestry GWAS summary statistics. By jointly modelling association signals across ancestry groups while accounting for ancestry-specific...