Westlake University

Gold Nanourchins Potentiate Intravesical Chemotherapy by Accelerating Drug Internalization within a Short Instillation Window

Abstract Intravesical chemotherapy is a standard adjuvant treatment for nonmuscle-invasive bladder cancer after transurethral resection, but its efficacy is limited by drug exposure resulting from urinary dilution and physiological voiding. Most current delivery strategies aim to...

A pair of chitosan receptors confer broad-spectrum fungal resistance

Chitosan, a major fungal cell wall component, activates plant immunity, yet the underlying perception mechanism remains unknown. In this study, we identified OsFID1, an apoplast-localized DUF26 domain protein, as a chitosan-binding receptor essential for chitosan-triggered immuni...

Asymmetric Alkylation of α-Cyanoketimines with Alkyl Bromides Catalyzed by Bis-Cinchonium Salts

Abstract The SN2 reaction constitutes one of the most fundamental bond-forming transformations in organic chemistry, finding numerous synthetic applications across pharmaceutical, agrochemical, and materials science. However, the development of new catalysts for asymmetric SN2 re...

Trajectory-Constrained Feature Transformation Optimization Framework for Stable Tabular Data Reprogramming

Tabular data reprogramming is a cornerstone of Data-Centric AI, which seeks to mathematically reconfigure raw features into more expressive and model-efficient representations. This process has traditionally relied on extensive manual engineering. Further, recent automated featur...

JustEvo: A Prior-Guided Adaptive Mixture-of-Experts Framework for Multifunctional Protein Directed Evolution

Abstract Machine-learning-guided directed evolution can reduce the experimental burden of protein engineering by prioritizing variants before they are tested. In practice, however, many campaigns begin with few or no target-specific measurements, face choices about how to use het...

Optimisation-based motion control for AUVs under non-linear wave-current disturbances

With the increasing exploitation of marine resources, autonomous underwater vehicles (AUVs) are being applied more extensively in a variety of tasks, such as maritime search, rescue, and marine archaeology. The attitude stability of AUVs can be significantly disturbed by highly n...

Confined Phase Transition Infiltration Coupled With In Situ Pore Sealing: Constructing Hard Carbon Rich in Closed Pore for Plateau‐Capacity‐Dominated Sodium Storage

Biomass‐derived hard carbon (HC) is a promising candidate for anode materials in sodium‐ion batteries (SIBs). However, abundant open pores generated during activation process often lead to severe proliferation of the solid electrolyte interphase (SEI) and irreversible Na + consum...

Magnetic granular matter: A review of phenomena and modeling approaches

Abstract Magnetic granular matter extends classical granular physics through the introduction of tunable, long-range dipolar interactions. These interactions give rise to a wide range of collective phenomena, including field-aligned chain formation, enhanced cohesion, anisotropic...

USF-Net: a Unified Spatiotemporal Fusion Network for ground-based remote sensing cloud image sequence extrapolation

Ground-based remote sensing cloud image sequence extrapolation is a key research area in the development of photovoltaic power systems. However, existing approaches exhibit several limitations:(1)they primarily rely on static kernels to augment feature information, lacking adapti...

RobustSCI: Beyond reconstruction to restoration for snapshot compressive imaging under real-world degradations

Deep learning has greatly advanced video Snapshot Compressive Imaging (SCI), but most existing methods are developed for reconstructing videos from relatively clean or idealized compressive measurements. In practical capture, motion, low illumination, and sensor imperfections can...

Harnessing Differential Restriction of Molecular Motion within a Single Fluorophore for Versatile Bioimaging

Abstract Numerous studies have highlighted how differently restricted molecular motions within molecular packing can profoundly alter the photophysical properties of fluorophores. However, most investigations remain confined to solid-state luminescence polymorphism, while extendi...

Aerobic Dehydrogenation by Coupled Electrochemical Reactions Governs Room-Temperature Proton Defect Chemistry in Functional Oxides

Abstract Tuning functional oxides by controlling ionic point defects is a well-established paradigm for designing tailored functionalities. At elevated temperatures, this is usually achieved by tuning ambient oxygen partial pressure (pO2) to regulate oxygen chemical potential and...

Nonadiabatic Dynamics near Multiple Light-Induced Conical Intersections under Bichromatic Driving: Quantum Wave-Packet Dynamics versus Floquet Surface Hopping

Abstract Light-induced conical intersections (LICIs) create externally tunable pathways for nonadiabatic transitions, enabling the active control of molecular photophysical and photochemical processes. However, both the dynamics near multiple LICIs under bichromatic driving and t...

Plasmonic Nature of the “Blue State” in the WO3 Photoelectrode: Carrier Dynamics and Its Impact on Photoelectrochemical Water Oxidation

Abstract This study discusses the photophysical nature of the commonly observed “blue state” in WO3 photoanodes during photoelectrochemical water splitting. We demonstrate, using ultrafast transient absorption spectroscopy, that photoexcitation of the blue state of WO3, generated...

Exploring buoyancy and thermal equilibration with a Galileo thermometer

Abstract Galileo thermometers are often used to demonstate buoyancy and density. In this article, a Galileo thermometer is used as the basis of a classroom activity which extends beyond Archimedes’ principle. Observations were made during cooling and localised heating of the ther...

Ultrasound-activated Cu2−XSe/TiO2 heterostructured nanosonosensitizer enables coordinated induction of ferroptosis and cuproptosis for tumor immunotherapy

Triple-negative breast cancer (TNBC) is a highly aggressive subtype characterized by the absence of actionable molecular targets, high metastatic propensity, and limited responsiveness to current immunotherapies. Although immune checkpoint inhibitors show promise, their clinical...

No Universal Remainder Rate for Chambolle-Dossal Acceleration

Chambolle-Dossal acceleration guarantees F(x_n) - F* = o(n^(-2)) for every fixed smooth convex loss with a minimizer. We show that this qualitative improvement admits no universal quantitative rate. For every damping parameter alpha > 3 and positive nondecreasing gain G(n) tendin...

Biocatalytic Redox Cascade Enabled Site-Selective Direct β-Alkylation of Cyclopentanones

Abstract Alkylation of carbonyl compounds is among the most widely practiced transformations in organic synthesis. While extensive methods exist for functionalization at the ipso and α-positions, direct β-alkylation remains a significant challenge, especially for cyclic ketones....

Persistent Chiral Diradicals via SUMO–LUMO Inversion: Modular Synthesis, Electronic Structures, and Redox‐Switching Properties

ABSTRACT Integrating chirality into organic open‐shell architectures holds immense promise for molecular spintronics and advanced optoelectronics. However, achieving simultaneous chemical persistence, configurational stability, and practical synthetic accessibility remains a form...

Persistent Chiral Diradicals via SUMO–LUMO Inversion: Modular Synthesis, Electronic Structures, and Redox‐Switching Properties

ABSTRACT Integrating chirality into organic open‐shell architectures holds immense promise for molecular spintronics and advanced optoelectronics. However, achieving simultaneous chemical persistence, configurational stability, and practical synthetic accessibility remains a form...