Westlake University

Gut Microbiota-Derived Indole-3-propionic Acid Attenuates Titanium Dioxide Nanoparticle-Induced Liver Injury by Targeting Kupffer Cells via the Gut–Liver Axis

Abstract Nanotitanium dioxide (nTiO2) is widely used as a food additive, leading to chronic dietary exposure and rising health concerns. Although adverse effects on the liver and gut microbiota have been individually investigated, whether gut microbiota mediates nTiO2-induced liv...

siRNA‐Loaded Metal‐Organic Layers for Targeted Gene Silencing and Radiotherapy Enhancement

ABSTRACT Radiotherapy (RT) remains a cornerstone in cancer treatment; however, its therapeutic efficacy is often limited by tumor fibrosis and radioresistance, primarily driven by transforming growth factor‐β (TGF‐β) upregulation. To address these challenges, we developed a tris(...

A canonical role of SMAD4 in safeguarding 3D genome architecture to suppress lung tumorigenesis

Dysregulation of three-dimensional (3D) genome architecture is a hallmark of cancer, yet the mechanisms by which its disruption drives tumorigenesis remain incompletely understood. Here, we demonstrated that SMAD4 regulated 3D genome organization through its canonical transcripti...

The imaging features of neurovascular compression in hemifacial spasm patients

Neurovascular compression is considered the main cause of primary hemifacial spasm. However, it also occurs on the asymptomatic facial nerves in primary hemifacial spasm patients and in healthy controls. This study aimed to compare neurovascular compression features among the thr...

Spectral Matching and Spatially Dependent Polarization‐Selective Attenuation in Chiral Au‐SiO 2 ‐Quantum Dot Nanohybrids

ABSTRACT Discrete colloidal nanohybrids that combine efficient achiral emitters with chiral plasmonic nanostructures offer a promising route to solution‐processable circularly polarized luminescence (CPL)‐active materials. Here, we construct Au/SiO 2 /QDs nanohybrids by assemblin...

Elucidating Ionic Programming Thermodynamics of Oxide‐Ion‐Based Electrochemical Random‐Access Memory Devices

ABSTRACT Electrochemical random‐access memory (ECRAM) enables analog conductance modulation by tuning the carrier concentration in the channel, making it a promising hardware platform for neuromorphic computing. Consequently, elucidating the quantitative relationship between the...

Superradiant quantum phase transition can be easier with disorder

We investigate the influence of strong static disorder on the transition frequency of molecules to the superradiant quantum phase transition in the Dicke model. A spin-fermion mapping is employed to recast the Dicke model into a coupled fermion-boson problem, which is subsequentl...

Spatiotemporal all-optical diffractive neural networks empowered by spatiotemporal light field manipulation

All-optical neural networks (AONNs) offer significant potential for feature detection and pattern recognition by leveraging light-speed processing, high parallelism, and low energy consumption. However, traditional AONNs are limited to spatial light intensity distributions for bo...

Geometrical-optics resonator photonics

Conventional waveguide optical resonators face inherent limitations of low damage thresholds, limited coupling tunability, and stochastic resonance. To overcome these, we introduce a geometrical-optics resonator (GOR) framework, emulating free-space reflection and thin-film coupl...

Solution‐Processed Sandwich‐Structured Organic Photovoltaics

Current organic photovoltaic (OPV) devices still rely on complex multilayer architectures, which inevitably increase OPV production costs. Here, we propose a simple sandwich‐structured OPV device composed solely of a bottom electrode/active layer/top electrode configuration, with...

Photothermal-Induced In Situ Crystallization of Perovskite Nanocrystals and the Application on Micro–Nano Defect Detection

Abstract Micro–nano defects on the optical elements are critical factors limiting the maximum light intensity tolerance and system reliability. Developing an accurate and efficient method for defect detection remains a significant technical challenge. Notably, under laser irradia...

Conserved nuclear receptor antagonism balances Hippo and Notch to control tissue growth and tumor suppression

Nuclear receptors orchestrate diverse biological processes through ligand-dependent transcriptional control, yet how competing family members balance oncogenic signaling to maintain tissue homeostasis remains poorly understood. Here, we uncover an evolutionarily conserved antagon...

Bioactive Selenium Peptides Rescue Dopaminergic Neurodegeneration via Coordinated Signal Remodeling and Redox Reinforcement

Selenium-dependent antioxidant systems are critical for neuronal redox balance, but whether Parkinson’s disease (PD) involves systemic selenium deficiency or selective utilization impairment remains unclear. Using large-scale CSF and plasma proteomic datasets from the PPMI cohort...

Hole-extraction embedded ultrathin donor realized highly homogenized dense self-assembled monolayers enabling organic photovoltaic modules with a certified efficiency of 16.1%

Abstract Achieving uniform, large-area interfacial layers remain a definitive barrier to the scalable manufacturing of solution-processed organic photovoltaics (OPVs). Conventional self-assembled monolayers (SAMs) frequently suffer from stochastic aggregation and incomplete cover...

Integration of proteomic aging clocks in a phase 2a clinical trial supports simultaneous geroprotective assessment

Abstract Drugs for aging-related diseases may modulate aging itself, but standard clinical trial designs cannot detect such effects. Aging clocks could close this gap, but epigenetic models often yield inconsistent, hard-to-interpret results. In contrast, proteomic clocks, by tra...

A perspective on training machine learning force fields for solid-state electrolyte materials

Abstract Machine learning force fields enable high-accuracy modeling of solid-state electrolytes (SSEs). This perspective evaluates dataset size, reference quality, and model architectures. We show that crystalline frameworks of bulk SSEs favor efficient learning, prioritizing da...

Bioinspired strong and rigid fusion-spun graphene fibers for harsh robotics

High-performance fibers with the merits of lightweight and high strength are indispensable to modern industry. However, the performance trade-off between tensile strength and bending rigidity limits their more applicational possibilities as structural materials. Inspired by the h...

Fluorescent protein ticker tape (FPTT): Multiplexed recording of transcriptional dynamics in living cells and in vivo

Recording and real-time imaging of promoter activities are critical for deciphering signaling cross-talk, but technologies for simultaneously capturing multiple transient events in living cells are lacking. Here, we design fluorescent protein–based ticker tapes (FPTT) for multipl...

Longitudinal plasma phosphorylated tau217 classification and the association with Alzheimer's disease progression

Abstract INTRODUCTION Longitudinal diagnostic and prognostic validity of plasma phosphorylated tau217 (p‐tau217) in Alzheimer's disease (AD) remains uncertain. METHODS In this multi‐cohort study of 2117 individuals, we established baseline plasma p‐tau217 thresholds for amyloid‐β...

Bonded Water Is an Integral Component of Dissolved Organic Matter in the Ocean

Abstract Dissolved organic matter (DOM) in the ocean, as one of the largest pools of reduced carbon on Earth, plays an important role in the global carbon cycle, yet its chemical structure remains largely unknown. Here we show that high molecular weight DOM (HMW‐DOM) contains app...