University of Virginia

Diagnosing year-round ozone-relevant VOC reactivity under meteorological constraints in urban Beijing

Abstract Static volatile organic compound (VOC) rankings can identify abundant or reactive compounds, but their ozone relevance depends on the meteorological and photochemical state during ozone production. Here we combine yearlong hourly observations of speciated VOCs in urban B...

International Society of Urological Pathology Multidisciplinary Expert Consultation Conference on Evaluation of Treatment Effects in Prostate and Bladder Cancer

Treatment effects in the urinary bladder are variable and range from localized post-transurethral resection changes to widespread systemic therapy effects. The International Society of Urological Pathology (ISUP) organized a consensus meeting in Vienna, Austria, in September 2025...

Does the National Resident Matching Program Rank List Predict Accreditation College of Graduate Medical Education Trainee Performance Among Multispecialty Pain Medicine Fellows? A Multicenter Study

Abstract Background Training programs seek to match fellows who will perform well during training. The National Resident Matching Program (NRMP) allows programs to choose the most capable trainees, with higher ranked applicants expected to perform better. Pain medicine is one of...

Peroneal Muscle Size and Quality Changes after Impairment-Based Rehabilitation in Patients with Chronic Ankle Instability

Background Peroneal muscles are the primary stabilizers against ankle inversion movements associated with lateral ankle sprains. Individuals with chronic ankle instability (CAI) demonstrate peroneal muscle deficits including decreased strength, slower nerve conduction velocity, a...

CDK8 phosphorylation of DELLA limits Mediator recruitment in gibberellin signaling

Gibberellin (GA) promotes plant growth primarily by triggering degradation of DELLA transcription regulators, yet how DELLA activity is fine-tuned dynamically by phosphorylation independently of proteolysis remains poorly understood. Here, we show that the CDK8 kinase module of t...

Humans in the Loop: The Next Frontier in the Credibility Revolution

Something is amiss in empirical economics. Despite the advances of the credibility revolution, published estimates tend to be inflated and overconfident. We argue that this stems from a weakness in the dominant econometric framework: treating the researcher like a calculator that...

Analyzing Residential Speeding Using Connected Vehicle Data: A Case Study in the Charlottesville, VA Area

This study uses connected vehicle data to analyze speeding behavior on residential roads. A scalable pipeline processes trajectory data and supplements missing speed limits to generate summaries at OpenStreetMap’s way ID level. The findings reveal a highly skewed distribution of...

Single-cell profiling identifies obesity-disrupted brain glucose sensing

Abstract Neuronal nutrient sensing in the hypothalamus and brainstem is thought to regulate energy and glucose homeostasis, yet how these brain regions respond to elevated adiposity or blood glucose remains unclear. We performed single-nucleus RNA-sequencing on 75,787 cells from...

Robust Antiferroelectric Response in the Pbca Phase of Hafnium Zirconium Oxide via Aluminum Substitution

ABSTRACT Hafnium zirconium oxide (HZO) has attracted attention for applications in nonvolatile memory and energy harvesting devices. However, it faces practical challenges such as insufficient endurance. One promising strategy to address this limitation is the utilization of anti...

Understanding the Research Needs and Educational Methods of Surgeons to Help Guide Future Spine Deformity Research: A Survey of AO Spine Members

Study Design Cross-sectional survey. Objective Outcomes research has significantly shaped patient management in spine deformity care, while the dissemination of research remains a challenge. To guide future research directions, this study surveyed AO Spine members to identify the...

Understanding genomic landscapes of differentiation in round-tailed horned lizards ( Phrynosoma modestum )

Population divergence is promoted by divergent selection and inhibited by gene flow, but the mechanisms of and relationship between these two processes remain poorly understood. Developing a well-informed hypothesis of the selective pressures underlying divergence in a natural po...

Applications of the circle product with a right Com-module to the theory of commutative ring spectra

If Com is the reduced commutative operad, the category of Com-algebras in spectra is the category of non-unital commutative ring spectra. The theme of this survey is that many important constructions on Com-algebras are given by taking the derived circle product with well-chosen...

Systematic multivariate analysis of chromatin complex dependencies reveals Set1C/COMPASS as a melanoma-enriched epigenetic vulnerability

Abstract Epigenetic dysregulation is a common feature of cancer. It creates vulnerabilities arising from an increased reliance on chromatin-based mechanisms that sustain malignant transcriptional states. While many chromatin regulators are broadly required for cellular viability,...

Differences in Baseline Demographic Characteristic and Complexity of Patients Based on Distance Traveled to Academic Center for Surgery

Background Many patients undergoing total hip (THA) or knee arthroplasty (TKA) require specialty surgical care. Therefore, referral to tertiary academic medical centers may increase, but may predispose for worse outcomes. This work sought to assess baseline characteristics as wel...

ODIN: Confirmation and 3D Reconstruction of Six Massive Protoclusters at Cosmic Noon

Abstract Protoclusters represent sites of accelerated galaxy formation and extreme astrophysical activity characteristic of dense environments. Identifying massive protoclusters and mapping their spatial structures are therefore crucial for understanding how large-scale environme...

An axon-intrinsic loop restricts nerve regeneration through axonal protein synthesis

ABSTRACT Injured axons synthesize the RNA Binding Protein KHSRP that promotes mRNA decay and slows nerve regeneration. Axotomy-induced increase in axoplasmic Ca 2+ activates axonal Khsrp translation, and while Ca 2+ returns to pre-injury levels within 16 hours post-axotomy, axona...

Credit or Constraint: Postcolonial Feminist Ethics of Empowerment in Microfinance

Abstract The microfinance industry has long been promoted as a “win-win” intervention in the Global South, producing both economic returns and social benefits. The industry disproportionately targets women as borrowers. In this paper, we argue that the ethical narrative of microf...

Propensity-matched case control study of anti-interleukin-23 therapies in Clostridioides difficile Infection

Abstract Background Clostridioides difficile infection remains a major cause of infectious morbidity and mortality, largely driven by a dysregulated, toxin-mediated host immune response that current pathogen-targeted therapies fail to address. Interleukin-23-driven Th17 responses...

Policy Window as a Trapdoor: Rethinking the Multiple Streams Framework through the Defunding of U.S. Public Media

This article analyses the 2025 defunding of U.S. public media as a critical case to revisit Kingdon’s multiple streams framework (MSF). While MSF offers a useful heuristic for understanding policy change through the convergence of problem, policy, and political streams, its expla...

Intra-abdominal Bowel Dilation in Experimental Gastroschisis Is Associated With a Modifiable Transcriptomic Program of Intestinal Dysfunction

OBJECTIVE: To characterize intestinal transcriptional profiles in gastroschisis, their temporal evolution, and response to fetal intervention. SUMMARY BACKGROUND DATA: Gastroschisis causes significant intestinal dysfunction, with intra-abdominal bowel dilation clinically shown to...