University of Virginia

Shared patterns of human milk composition link mammary gland function to infant growth

The mammary gland produces nutrient-rich human milk (HM), yet how mammary functional state shapes HM composition and infant outcomes remains poorly understood. We used HM multi-omics - metabolomics, proteomics, micronutrients, macronutrients, and HM oligosaccharides - across 1,54...

Sleep Healthy Using the Internet: A Meta-Analysis of Twenty Years of Research on a Digital Cognitive Behavioral Therapy for Insomnia Program

Abstract Study Objectives To summarize two decades of research on Sleep Healthy Using the Internet (SHUTi), among the most-studied digital Cognitive Behavioral Therapy for Insomnia programs. Methods PubMed, CINAHL, Web of Science, and PsycINFO were comprehensively searched throug...

Minimal-actuation feather star–inspired soft swimmers for multimodal 3D maneuverability

Complex, three-dimensional (3D) motions typically require actuator arrays and complex control architectures. Here, we present a feather star–inspired soft robotic swimmer that uses only two pneumatic inputs to produce three distinct and switchable swimming modes: jellyfish-like p...

Structure-Dependent Effects of Lipid Conjugation on Cytosolic Accumulation in Escherichia coli and Mammalian Cells

Abstract Lipidation is a widely used strategy to promote membrane permeation, yet whether the factors governing lipid-driven accumulation are shared across mammalian and Gram-negative envelopes remains unresolved. Here, we apply the chloroalkane azide-based membrane penetration (...

Architecture-Driven Supramolecular Assembly in Bottlebrush Hydrogels

Abstract Supramolecular materials are traditionally designed by strengthening noncovalent interactions or increasing the number of binding motifs. Here, we demonstrate a fundamentally different strategy: using macromolecular architecture to amplify weak molecular interactions int...

The Composite Spectrum of QSO Absorption Line Systems in DESI DR2

Abstract We present details regarding a composite spectrum of quasar (QSO) absorption line systems. In this composite spectrum, we identify more than 70 absorption lines and observe oxygen and hydrogen emission features at a higher signal-to-noise ratio than any previous study. A...

The silent pandemic: the overlooked toll of stroke compared to COVID-19

The COVID-19 pandemic will be remembered as one of the defining health crises of the modern era. The World Health Organization reported approximately 7 million deaths attributed to COVID-19 globall...

Barriers to Reducing Subthreshold Phototherapy for Neonatal Jaundice

OBJECTIVE: In a national, multicenter quality improvement (QI) collaborative to reduce subthreshold inpatient phototherapy, the proportion of subthreshold encounters was high at baseline and remained high after the intervention period. This study aimed to assess why clinicians st...

Adaptive cut reveals multiscale complexity in networks

Abstract Hierarchical clustering and community detection are important problems in machine learning and complex network analysis. A common approach to identify clusters is to simply cut dendrograms at some threshold. However, single-level cuts are often suboptimal in terms of cap...

Anticancer Drugs and Cancer-Associated Thrombosis

The rapid development of novel cancer therapies has considerably improved the care of cancer patients and cancer-related survival; however, these therapies are associated with a broad range of adverse events that have become a major burden in this population. Alongside other canc...

Correlating biaxial stress to metastable phases in Hf0.5Zr0.5O2 on substrates with different coefficients of thermal expansion

The effects of biaxial stress in hafnium zirconium oxide (HZO) thin films on the phase constitution and dielectric response are studied through the preparation of HZO films on substrates with coefficients of thermal expansion (CTE) ranging from 0.52 to 12.97 × 10−6 K−1. X-ray dif...

Quantum parameter estimation with uncertainty quantification from continuous measurement data using neural network ensembles

Abstract We show that ensembles of deep neural networks, called deep ensembles, can be used to perform quantum parameter estimation while also providing a means for quantifying uncertainty in parameter estimates, which is a key advantage of using Bayesian inference for parameter...

Code-Switching, Code-Stitching: A Macaronic Poetics?

What kind of home has poetry provided for code-switching over the course of the last hundred years? Given that speech and literary writing overlap but are distinct from one another, how should we think about the code-switching that’s particular to poetry? What can we learn from t...

A phase II pilot trial of an indoleamine 2,3-dioxygenase-1 (IDO1) inhibitor (INCB024360) plus a multipeptide melanoma vaccine (MELITAC 12.1) in patients with advanced melanoma, with sequential evaluation of the tumor microenvironment

Indoleamine 2,3-dioxygenase-1 (IDO1) can mediate immune dysfunction by reducing tryptophan (Trp) and increasing kynurenine (Kyn). The CITN-04 clinical trial (NCT01961115) tested the safety and clinical activity of combination therapy with IDO1 inhibitor epacadostat (INCB024360) p...

Solvation Mediates the Mechanisms of Homogeneous Co-Electrocatalysis at Interfaces

Abstract Electrochemical reactions occur near electrode surfaces─this interfacial environment has long obscured the mechanistic insight required to improve selectivity and overall rates. While traditional linear spectroscopies can be used to probe bulk chemical changes, the inter...

A multicenter multistate modeling on the natural history of liver decompensation: Longitudinal analysis of 1777 patients.

BACKGROUND: Cirrhosis often remains silent until decompensation, after which survival deteriorates sharply. Contemporary, transition-aware estimates are limited, especially in Asian-predominant cohorts. We analyzed trajectories from compensated advanced chronic liver disease (cAC...

Regional Anesthesia for Patients Undergoing Cardiac Surgery: An Overview for the Bedside Nurse

Background Regional anesthesia techniques are becoming increasingly used to reduce postoperative pain, reduce opioid use, and improve other outcomes in patients undergoing cardiac surgery. Objective To provide critical care nurses with an overview of regional anesthesia technique...

Consensus-based clinical and research recommendations for use of glucagon-like peptide-1 receptor agonists in the context of eating disorders: a modified Delphi study.

Glucagon-like peptide-1 receptor agonists (GLP-1RAs), initially developed for type 2 diabetes management and later expanded to obesity treatment, have shown preliminary efficacy in reducing binge eating episodes. However, the appetite-suppressing and weight-loss effects of GLP-1R...

Enhancing electromagnetic calorimeter signal reconstruction with machine learning-based noise discrimination

Abstract Calorimeters operating in high-radiation environments are susceptible to damage, leading to increased noise that can significantly degrade energy resolution. A common way to mitigate noise is to apply a higher energy threshold on the calorimeter cells, typically set a fe...

JWST Nebular Spectroscopy of SN 2023qov: Circumstellar Dust Emission in a Normal Type Ia Supernova

Abstract We present panchromatic observations of the Type Ia supernova (SN Ia) 2023qov, ranging from ∼2 weeks before to ∼1 yr after maximum light. JWST near- and mid-infrared spectra at +276 and +363 days show ∼400 K dust emission that cools by ∼75 K between epochs, the first una...