University of Padua

Organizing healthcare delivery in the era of disease-modifying therapies for Alzheimer’s Disease: an Italian RAND/UCLA consensus

BACKGROUND: Alzheimer's disease (AD) poses a growing clinical and organizational challenge, requiring coordinated, multidisciplinary care models. In Italy, significant regional variability in resources and access to diagnostic services persists, while the implementation of commun...

Travel distance to tertiary healthcare reflects disease severity and medication access in Italian systemic sclerosis patients: a geographical study on adult-onset rare diseases from SPRING-SIR registry

Systemic sclerosis (SSc) is a rare, multiorgan disease in adults that requires specialized care. Commuting to tertiary medical centers poses a considerable burden and incurs significant costs, potentially affecting management choices. This study aims to describe the healthcare co...

Comparative evaluation of pyrolysis oils derived from lignocellulosic biomass and municipal solid waste as potential bitumen modifiers

The transition toward sustainable road construction has led to increased research on replacing conventional asphalt binders with bio-based and waste-derived alternatives. Bio-bitumen derived from lignocellulosic biomass and binders modified using domestic and industrial waste hav...

Dispersal diversity buffers species vulnerability to local extinction

Abstract Predicting species persistence within ecological communities is a fundamental challenge for both empirical and theoretical ecology. Existing methods span from mechanistic models, whose parameters are difficult to estimate from data, to statistical tools whose context-spe...

Clinical exit strategy in anti-VEGF therapy for neovascular AMD: incidence of recurrence and risk factors for relapse

PURPOSE: To evaluate the recurrence rate of neovascular activity after discontinuation of intravitreal anti-vascular endothelial growth factor (VEGF) therapy in patients with neovascular age-related macular degeneration (AMD) and to identify baseline clinical and imaging factors...

Institutionalized Patriarchy Beyond Representation: Rurality, Gender, and Political Participation Among Amazigh Women in Morocco

The objective of this article is to examine how gendered institutional practices constrain the substantive political participation of Amazigh-speaking women elected to local councils in Morocco. Although constitutional reforms, gender quotas, and the official recognition of Amazi...

Early Transition Metal Carbene Complexes as Photocatalysts: Unveiling Dual-Emission and Photo-reactivity

Abstract Photoactive transition metal complexes are playing a pivotal role in synthetic chemistry and application technologies, such as photocatalysis and light-emitting diodes, yet they often depend on precious metals. Early-transition-metal photosensitizers offer a promising, y...

Reconciling intrinsic and ecosystem water-use efficiency reveals physiological mechanisms underlying carbon-water coupling across biological scales

Understanding how carbon-water coupling scales from leaves to ecosystems remains a major challenge because water-use efficiency (WUE) metrics integrate physiological, hydrological, and ecological processes. We integrated tree-ring width, triple stable isotopes (δ13C, δ18O and δ2H...

CGM-derived disposition index estimates beta cell function in individuals with islet autoimmunity who do not require insulin treatment; changes in the disposition index precede changes identified by CGM metrics 1 year later

Abstract Aims/hypothesis Monitoring of beta cell function in individuals with islet autoimmunity who do not require insulin treatment (preclinical type 1 diabetes) is normally done via OGTTs, posing major challenges given the invasiveness of the test. Here, we validated a disposi...

Balanced Animal Nutrition for Better Feeds, Healthy Animals, Safe Food, and a Healthy Planet: A One Health Perspective—An Invited Review

Livestock production is increasingly expected to deliver not only higher output, but also better animal health and welfare, safer and more nutritious food, viable livelihoods, and lower environmental pressure. This invited review examines balanced animal nutrition within a One He...

The HEADSpAcE Data Center: An international data and biospecimen resource for head and neck cancer translational research

Head and neck cancer (HNC) comprises a heterogeneous group of malignancies with substantial variation in incidence, risk factors, and outcomes across populations. Existing studies are often limited by regional scope or lack integration of epidemiological, clinical, and molecular...

The fast and the studious? Ramadan observance and student performance

Abstract We examine how religious observance affects educational performance by studying the years in which Ramadan overlapped with the national end-of-secondary-school exams in the Netherlands. Using administrative microdata and a difference-in-differences design, we find that s...

VEGF pathway signalling across pulmonary neuroendocrine tumours: associations with histological subtypes in a multicentre study

Abstract The current classification of pulmonary neuroendocrine neoplasms (NENs) is primarily based on histomorphological criteria, which do not fully capture their underlying biological heterogeneity. This limitation is particularly evident among pulmonary carcinoids, a subgroup...

From Regional Evidence to National Implications: Life Cycle Assessment of Pulp–Paper Production Modes, Collaborative Strategies, and Energy Transition in China

Abstract The pulp and paper industry in emerging economies faces dual pressures to decarbonize while upgrading. This study applies a cradle-to-gate life cycle assessment, using 10,000 CNY product value as the functional unit, to compare stand-alone and integrated production modes...

Pembrolizumab-related hand and foot skin reaction

Hand and foot skin reaction (HFSR), usually associated with tyrosine kinase inhibitors, is characterized by painful erythema and hyperkeratosis at palmoplantar pressure points. HFSR differs from the more widely recognized chemotherapy-induced hand-foot syndrome (HFS) in terms of...

Mitochondrial Remodeling and Impaired Bioenergetics Define Neuronal Vulnerability in Fragile X-Related Disorders

Fragile X syndrome (FXS) and related conditions associated with FMR1 gene alterations have increasingly been linked to mitochondrial dysfunction, although most available evidence derives from peripheral cell models. Whether these abnormalities also occur in disease-relevant neuro...

Navigating an Inevitable Transformation: A Reflection on Responsible Scientific Writing Large Language Models Integration and the RULE-AP Consensus

Large language models (LLMs) are reshaping scientific communication in Anesthesiology and Pain Medicine. The RULE-AP Delphi consensus – convening 53 editors-in-chief – proposes a regulatory framework that distinguishes legitimate assistance from intellectual abdication. We argue...

Extraction dataset, risk-of-bias assessments and analysis code for Incremental value of integrating histopathology with omics for prediction in non-small-cell lung cancer: a systematic review and meta-analysis

This record contains the data and code supporting the systematic review and meta-analysis "Incremental value of integrating histopathology with omics for prediction in non-small-cell lung cancer: a systematic review and meta-analysis" (submitted to Briefings in Bioinformatics). T...

Electrostatic Lens of a Charged Vortex

We study the local electrostatic response of a charged superfluid in the presence of a cylindrically symmetric vortex, allowing both the particle density and the thermodynamic compressibility to vary with the radial coordinate. Starting from the electrostatic charge response obta...

Dietary and Parenteral Nutritional Management of Short Bowel Syndrome with Intestinal Failure in Adults: A Narrative Review

Short bowel syndrome (SBS) is the leading cause of chronic intestinal failure in adults, arising when the residual small bowel can no longer absorb the macronutrients, water, and electrolytes needed to sustain health without intravenous supplementation. Its management is, at its...