University of Naples Federico II

Plant‐Derived Bioactives and PPAR Signaling in Functional Dyspepsia: Mechanistic Insights and Therapeutic Perspectives

ABSTRACT Functional dyspepsia (FD) is a common disorder of gut‐brain interaction in which gastric sensorimotor abnormalities may coexist with impaired duodenal barrier function, low‐grade immune activation, and altered neuroimmune signaling. Peroxisome proliferator‐activated rece...

A Multiplatform Chemical Perspective on Coffee Identity: Interplay Between Origin, Cultivar, and Fermentation Time

Abstract Green coffee bean chemistry is shaped by the geographic origin, plant genetics, and post-harvest processing, but their relative contributions across complementary chemical layers, within a single, tightly controlled context, remain comparatively underexplored. We applied...

Some Reflections on THP from a Dual Perspective

This paper analyses and discusses the role of the HET in university curricula, confirming the importance and usefulness of THP. The approach used is twofold. On the one hand, it recounts and expresses the doubts and uncertainties that mainstream teaching raises in curious and cri...

Revealing seismic sequence characteristics in the south-eastern Alps and the Western Dinarides by clustering analysis and refined location

Abstract The characterization of seismic sequences provides key constraints on fault geometry, rupture processes, and seismic hazard. In this study we investigate seismicity recorded between 2015 and 2024 in the south-eastern Alps and Western Dinarides (SEAWD), one of the most te...

Management of Acute Periodontal Conditions—The EFP S2k Level Clinical Practice Guideline

BACKGROUND: The European Federation of Periodontology (EFP) has developed Clinical Practice Guidelines (CPGs) for the treatment of periodontitis and for the management of peri-implant diseases. In accordance with the 2018 Classification, acute periodontal conditions are character...

Matrix-engineered electrospun MIP–MWCNT nanofiber interfaces for programmable ammonia recognition and transduction

Electrospun polymer nanocomposites offer a versatile route to engineer functional interfaces in which molecular recognition, analyte transport, hydration and electrical transduction are integrated within a single fibrous layer. However, the host polymer is often treated mainly as...

Browser-Native Federated Inference on Existing Italian SSN Clinical Workstations: A Peer-to-Peer Sovereignty-Preserving AI Architecture for Italian Regional Health Networks

Clinical adoption of large language models (LLMs) in public healthcare faces a structural impasse: the capital expenditure of centralised high-performance computing on one side and the privacy risk of routing patient data through third-party cloud interfaces on the other. Italian...

A Qualitative Study of Barcelona Food Tours: Representing Gastronomic Heritage Through Urban Culinary Imaginaries

Gastronomy has acquired a central role in contemporary tourism where experiences centered around food are increasingly developed. Food tours have become a prominent urban tourism product due to their ability to connect tourists with local communities. These tours promote the expl...

Bioactive Nanocoatings Encode Bacterial Settlement Cues for Coral Restoration

Abstract Increasing larval settlement can substantially accelerate coral reef restoration by overcoming a key bottleneck in coral population recovery. Successful settlement depends on biological and chemical cues associated with microbial biofilms and crustose coralline algae tha...

Hit It before It Starts: Targeting a (3 + 1) Hybrid Non-canonical G-Quadruplex to Silence PARP1 in Cancer

Abstract Error-prone DNA repair pathways promote genomic instability and cancer progression. Notably, Poly(ADP-ribose) polymerase-1 (PARP1)-directed alternative non-homologous end joining plays a pivotal role in cancer, including Multiple Myeloma (MM), conferring vulnerability to...

Entropy-Based Analysis of Olfactory EEG as a Candidate Biomarker for Early Mild Cognitive Impairment Detection: A Proof-of-Concept Study

A decline in olfactory ability represents one of the earliest signs of Alzheimer’s disease (AD) and can be valuable information for early diagnosis at the stage of mild cognitive impairment (MCI). Nevertheless, the underlying neurophysiological mechanisms of olfactory impairment...

Experimental and numerical study of a bio-methane heavy-duty engine equipped with a pre-chamber ignition system: a focus on flame kernel development and combustion process under lean conditions

In this work, in-depth experimental and numerical analyses are carried out on a single-cylinder bio-methane heavy-duty spark ignition engine, mounting a passive pre-chamber, to investigate the flame kernel formation, the combustion process and the overall performance. In the firs...

Biovid dataset and challenge: biometric user recognition on smartphone data in real-world conditions

Abstract User authentication is more and more crucial in everyday life, with researchers developing sophisticated, yet easy-to-use, approaches to enforce secure authentication while providing a smooth user experience. This is particularly true in mobile authentication, in which t...

Pharmacokinetic and Pharmacodynamic Interactions Between Anti‐Asthma Drugs and Medicinal Plants: A Comprehensive Review

ABSTRACT Asthma affects 260–300 million people worldwide. About 20%–35% of patients use medicinal plants with their asthma medication, often without telling their clinicians. Disclosure rates are low; up to 42% of asthma outpatients use herbal products, with no records in their c...

Valorization of Wheat Straw Hydrolysate into Succinic Acid by Fermentation with Actinobacillus succinogenes

Succinic acid (SA) production from agro-industrial waste, such as lignocellulosic biomass, has been gaining interest. Traditionally, it is synthesized from petrochemical sources, a process associated with negative environmental impacts. In recent decades, efforts to develop clean...

Time‐Dependent Diagnostic Yield and Therapeutic Impact of Implantable Loop Recorders, Brugada Syndrome as the Exception

ABSTRACT Introduction The optimal duration of implantable loop recorder (ILR) monitoring remains uncertain and may differ according to the indication for implantation. We evaluated whether the time‐dependent diagnostic yield and clinical relevance of ILR‐detected arrhythmias diff...

Energy transition as the core of climate discourse: Mapping social representations in digital public debate

Climate change governance increasingly unfolds through energy transitions, yet the symbolic conditions under which these transitions are publicly interpreted remain insufficiently mapped. This study examines the representation of climate change in digital discourse during 2025, f...

Dengue virus serotype classification from complete genomes using a Transformer with chunk-based sequence modeling and explainability analysis

Artificial intelligence is increasingly used for genomic surveillance of infectious diseases, but predictive models must be evaluated under realistic generalization settings and interpreted cautiously. We present XAI-DENFormer, an explainability-oriented framework for dengue viru...

Laminar pattern disruption in fetal incipient polymicrogyria: insights from post-mortem magnetic resonance imaging and neuropathological correlation

Abstract Background Polymicrogyria is a heterogeneous cortical malformation resulting from disruption of multiple processes of cortical development, either genetically determined or acquired. Objective To characterize early imaging and histopathological features of incipient poly...

A new bio-enhanced iron formulation with improved iron bioaccessibility modulates intestinal pathways involved in iron uptake, storage and export

Abstract Iron deficiency remains a major global health concern, and the efficacy of oral iron supplementation is often limited by poor bioavailability and gastrointestinal intolerance. In this context, biofortified biological matrices may represent an alternative strategy to impr...