University of Naples Federico II

Electrochemical detection of gallic acid in commercial beverages empowered by the use of paper-based tool to collect and analyze

A simple and innovative paper-assisted electrochemical approach was developed for the determination and temporal monitoring of gallic acid in commercial beverages. The proposed platform combines low-cost screen-printed electrodes with wax-patterned paper discs, enabling the paper...

Comparative modelling of large-scale 3D genome re-arrangements in different viral infections

Abstract Viruses can re-structure the architecture of host cells genome and also alter their epigenomic landscape. In this study, we investigate with polymer physics modelling virus induced genome re-organization by using available datasets from different viral infections causing...

ARMAX-based capacity fade estimation for lithium-ion cells across state-of-charge and temperature variations

This paper presents an ARMAX-based framework for State-of-Health (SoH) estimation of lithium-ion batteries using short-duration impulse-response characterization. Battery dynamics are identified through a third-order equivalent circuit model whose parameters are estimated under d...

Addressing fusiform gyrus dysfunction in schizophrenia, theory of mind, and implications for antipsychotics’ response and resistance: A systematic review and critical appraisal

Background The Fusiform Gyrus (FG), a brain region relevant for the interaction between cognitive processes and emotional behavior, especially emotion recognition and interpretation of social cues, has been linked to the pathophysiology of schizophrenia conceptualized as a disord...

The Versatility of Pomegranate: From Phytochemical Diversity to Antimicrobial and Translational Applications

Pomegranate is increasingly being recognized as a versatile source of bioactive compounds with antimicrobial, antioxidant, anti-inflammatory, and microbiota-modulating potential. Beyond the edible arils and juice, peel, seeds, leaves, flowers, and other agro-industrial by-product...

Pediatric Arboviral Infections in Europe: Epidemiology, Clinical Features, Diagnosis and Prevention

Arboviral infections, including West Nile virus (WNV), dengue virus (DENV), chikungunya virus (CHIKV), Zika virus (ZIKV), and, to a lesser extent, Oropouche virus (OROV), pose a heterogeneous and evolving challenge for pediatric health in Europe. The increasing presence of compet...

Tunnel-form system as an ideal solution for seismic regions: a numerical study based on life-cycle cost analysis

Abstract The present study focuses on the evaluation of the life-cycle cost of concrete tunnel-form system through an innovative approach. Such life-cycle cost analysis accounts for the roles of different building components in generating injury, fatalities, and downtime. Using s...

New variations on the theme of Baer’s theorem

Abstract Let $$\gamma _s(G)$$ γ s ( G ) and $$Z_s(G)$$ Z s ( G ) denote the s -th terms of the lower and upper central series of a group G , respectively. A classical theorem by R. Baer states that if $$Z_s(G)$$ Z s ( G ) has finite index in G , then $$\gamma _{s+1}(G)$$ γ s + 1...

Design and analytical validation of Nexthyro 2.0, a custom next-generation sequencing panel integrating DNA mutation profiling and RNA fusion detection for routine thyroid pathology specimens

Abstract The increasing role of molecular testing in thyroid pathology, from the pre-operative stratification of indeterminate fine-needle aspiration (FNA) categories to the management of advanced carcinomas, has prompted the development of institution-specific custom NGS solutio...

Hierarchical maritime traffic network generation from large AIS datasets: application to the West Mediterranean Sea case

Abstract We present a hierarchical scalable methodology to analyze the maritime traffic of year 2022 associated with cargo, tanker, and passenger vessels traveling within the West Mediterranean Sea. The methodology is based on data-mining and machine learning techniques to proces...

The role of controllable household appliances for effective uptake of digital services by consumers and communities in the energy transition

Digitalisation is transforming modern energy systems into complex socio-technical ecosystems where interconnected devices, user practices and governance structures must be considered together. To analyse this landscape and address relevant research questions concerning controllab...

LDL Cholesterol Lowering With Evolocumab Before Percutaneous Coronary Intervention for Acute Myocardial Infarction

Importance: Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibition is recommended as second- or third-line lipid-lowering therapy after myocardial infarction (MI), resulting in prolonged periods of inadequate low-density lipoprotein cholesterol (LDL-C) control. Whether...

Advancements and Future Directions in Loss Function Designs for Physics-Informed Neural Networks: A Comprehensive Review

Abstract This review synthesizes recent advances in loss function designs for Physics-Informed Neural Networks (PINNs), a transformative approach to solving partial differential equations (PDEs) by embedding physical laws into deep learning frameworks. We begin by exploring the f...

Identification and characterization of TrxA: a novel bacterial thioredoxin–metallothionein chimera

Abstract Heavy metals (HMs) are naturally occurring elements which can be essential, such as zinc, copper, and iron, or non-essential, including cadmium, mercury, and lead. While essential metals serve as cofactors in critical enzymatic processes, elevated concentrations of both...

Salivary hormones and adipokines are associated with glycemic control and early renal and cardiometabolic markers in children and young adults with type 1 diabetes

Abstract Purpose Type 1 diabetes (T1D) is recognized as a complex metabolic condition associated with hormonal dysregulation and early complications. This study aimed to evaluate salivary metabolic hormones and adipokines in children and young adults with T1D, and to assess their...

Underground hydrogen storage site suitability from the views of efficiency, cost, and risk — A site selection framework for decision-makers

Underground Hydrogen Storage (UHS) in porous media is emerging as a key enabler of large-scale, long-duration energy storage to support net-zero energy systems. However, determining suitable storage sites remains a complex, multidisciplinary challenge based on the integration of...

Influence of flow-type-dependent matrix rheology on droplet breakup in twin-screw extruded polymer blends

Abstract The morphology of immiscible polymer blends generated during twin-screw extrusion depends on the deformation history of the dispersed phase and on the matrix rheology. Here, this effect is investigated numerically in a two-dimensional, co-rotating, fully intermeshing bat...

Variation in meningioma recurrence risk estimates across observational cohorts: the influence of calendar time, WHO classifications, geographical settings, and healthcare systems

Abstract Purpose Recurrence risk estimates underpin meningioma research, including molecular classification and clinical trial benchmarking, yet are often based on retrospective or historical data. The aim of this study was to assess the variation of recurrence risk estimates acr...

On Some Functionals Involving Torsional Rigidity, Principal Eigenvalue and Perimeter

Abstract In this paper we study some relationships between the first Dirichlet Laplacian eigenvalue $$\Lambda (\Omega )$$ Λ ( Ω ) and the torsional rigidity $$T(\Omega )$$ T ( Ω ) of a domain $$\Omega $$ Ω . We consider the problem of optimizing the product $$\Lambda (\Omega )T(\...

Technologies of Transition: Pottery Production and Specialization in Early Rome and Its Neighbors. Neutron Activation Analysis of Regional Assemblages and a Mineralogical‐Petrographic Study of Impasto Chiaro‐Sabbioso

ABSTRACT The following paper investigates ceramic production and signs of specialization in Rome and the wider region during the early first millennium bce , through an archaeometric approach using Instrumental Neutron Activation Analysis (NAA), and complementary techniques. A to...