University of Naples Federico II

Influence of socio-economic inequalities and healthcare organisation on HPV vaccination coverage in both sexes in the Campania region: A population-based study between 2006 and 2023

Human papillomavirus (HPV) and hepatitis B vaccinations are the only immunisation programmes that directly prevent cancer. Despite the expansion of universal, gender-neutral HPV programmes, a free and actively offered vaccination does not ensure achievement of coverage targets. W...

The Italian Nanomedicine Platform (INP): national integration within the European nanomedicine ecosystem

Italy’s nanomedicine expertise has long developed in fragmented manner, with limited coordination across academia, clinical institutions, industry and regulatory bodies. The Italian Nanomedicine Platform (INP) was established to integrate discovery, preclinical validation, regula...

The pre-geometric origin of geometric trinity of gravity

Abstract The so-called geometric trinity of gravity is based on three distinct geometric features of spacetime, i.e. curvature, torsion and non-metricity, which give rise to equivalent dynamics for general relativity (GR), teleparallel equivalent of general relativity (TEGR) and...

A structural cardiac pathway mediates the risk of ischemic heart disease from TyG-related indices: A prospective cohort study

The triglyceride-glucose (TyG) index and its derivatives are surrogate markers of insulin resistance and are closely associated with cardiovascular risk. However, whether and to what extent they are associated with IHD risk through subclinical cardiac remodeling remains unclear....

A standardized field framework for integrated microbiological and geochemical sampling of deeply-sourced seeps across large-scale geological gradients

Accessing the deep subsurface biosphere remains a major challenge in Earth and planetary sciences. Drilling provides direct access but is costly, spatially restricted, and difficult to deploy at the scales required to investigate interactions between geological processes and micr...

Radiomics-based prediction of pituitary adenoma consistency: a systematic review and meta-analysis

Abstract Purpose Pituitary adenoma consistency significantly influences surgical strategy and outcomes, yet it cannot be reliably predicted using conventional imaging. By converting images into quantitative data, radiomics can identify imaging patterns that may not be distinguish...

Worried but Not Intending: When Expressive Suppression Dampens the Motivational Role of Health Worry in Colorectal Cancer Screening Among Older Adults

Objectives Health worry may promote engagement in preventive behaviors, but when poorly regulated it can also foster avoidance. This study examined the relationship between health worry and intention to participate in colorectal cancer screening, investigating the moderating role...

Bearing behavior of additively manufactured Onyx–Kevlar composites: effect of fiber content and mixed distribution

Abstract This study investigates the pin-bearing behaviour of additively manufactured Onyx–Kevlar composites, focusing on the interplay between fiber content and layer-wise distribution. Specimens were fabricated via Continuous Filament Fabrication with longitudinal Kevlar covera...

Primary Pap Smear Cytological Diagnosis of ASC-US: HR-HPV Genotyping and Follow-Up of HPV-Positive Patients

ASC-US refers to cytological abnormalities suggestive of squamous intraepithelial lesions (SILs) that are qualitatively or quantitatively insufficient for a definitive diagnosis. In addition to HPV infection, which is the etiological agent of preneoplastic and neoplastic cervical...

Numerical investigation of transom and double interceptor systems on a high-speed planing craft in regular waves with experimental validation

High-speed planing craft (HSPC) operating in waves can experience severe vertical motions and impact accelerations, potentially affecting operational performance and occupant safety. This study investigates the effects of a transom interceptor system (TIS) and a double intercepto...

The next-generation biomarkers in early-stage triple negative breast cancer

PURPOSE OF REVIEW: Despite maximal neoadjuvant chemoimmunotherapy, nearly 40% of early-stage triple-negative breast cancer (TNBC) patients fail to achieve pathological complete response, underscoring an urgent need for biomarkers capable of guiding treatment modulation. This revi...

HIPK2 loss promotes TDP-43 cytoplasmic mis-localization through MAPK-pathway and is associated with TDP-43 proteinopathy in vivo

Abstract Homeodomain Interacting Protein Kinase 2 (HIPK2) is a stress sensor kinase that has emerged as a key regulator of neuronal homeostasis and survival. In this study, we investigated the role of HIPK2 in neurodegeneration using both in vivo and in vitro models. We show that...

Real-world effectiveness and drug retention rate of risankizumab in patients with psoriatic arthritis: data from the multicentre GIRRCS cohort

Introduction Psoriatic arthritis (PsA) is a chronic heterogenous inflammatory disease characterized by a multidomain burden. Risankizumab, a selective inhibitor of the IL-23 p19 subunit, has shown efficacy in randomized trials; however, real-world data in PsA remain limited. We e...

Auditory associative learning drives synaptic responses in tail of the striatum spiny projection neurons

The association of cues with the absence or presence of danger is crucial to survival. The synaptic changes that enable association with the absence of danger are unknown, but a role for the tail of the striatum (TS) has been implicated. To investigate this, we conditioned mice t...

Regularization of singular time-dependent Lagrangian systems

Abstract One approach to studying the dynamics of a singular Lagrangian system is to attempt to regularize it, that is, to find an equivalent and regular system. In the case of time-independent singular Lagrangians, an approach due to A. Ibort and J. Marín-Solano is to use the co...

Palmitoylethanolamide as an Intestinal Gatekeeper: Linking Inflammation, Angiogenesis and Colorectal Cancer Interception

Angiogenesis is a major determinant of tumor growth, progression and metastatic potential, and its persistent activation is closely intertwined with chronic inflammation. This relationship is particularly relevant in malignancies that arise through a prolonged inflammation-to-car...

A trait-based persuasive framework for preference elicitation by social assistive robot

Human preferences are often ill-defined and shaped by contextual and situational factors, posing challenges for effective human–robot interaction. Social Assistive Robots can address this by employing adaptive, context-aware persuasive strategies to better elicit user preferences...

Early Versus Delayed Oxytocin Augmentation in Nulliparous Women with Spontaneous Dysfunctional Labour: A Systematic Review and Meta-Analysis

Background: The timing of oxytocin for slow labour progress rests on custom rather than evidence, and existing syntheses pool clinically distinct populations. Objectives: We restricted this systematic review to nulliparous women in established active-phase labour with a trial-spe...

Sphingolipid Remodeling and Extracellular Vesicle Signatures Reflect Disease Severity in Facioscapulohumeral Dystrophy Driven by Mitochondrial Dysfunction and Endoplasmic Reticulum Stress

Background: Facioscapulohumeral muscular dystrophy (FSHD) is a progressive and heterogeneous disorder lacking reliable circulating biomarkers for disease monitoring and therapeutic response. We hypothesized that metabolic dysregulation, lipotoxicity, and endoplasmic reticulum (ER...

Three-dimensional analysis of a single-step cylinder wake via stereoscopic particle image velocimetry

The present experimental study investigates the turbulent flow field past a single-step cylinder, characterized by a fixed ratio r between the large diameter D and the small diameter d equal to 2, for multiple values of the Reynolds number: R e D = 3000,5000 , and 7000. To recons...